NRG1 Isoform SMDF, Human, Recombinant
- CAS No.
- Chemical Name:
- NRG1 Isoform SMDF, Human, Recombinant
- Synonyms
- NRG1 Isoform SMDF, Human, Recombinant
- CBNumber:
- CB34817661
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
NRG1 Isoform SMDF, Human, Recombinant Chemical Properties,Uses,Production
General Description
Recombinant, human neuregulin 1 (NRG1), isoform SMDF (sensory and motor neuron-derived factor), consisting of amino acids 1-263, 117-296, and 162-296, each fused at the C-terminus to a His?Tag sequence and expressed in S. frugiperda Sf21 cells using a baculovirus expression system. The neuregulin (also known as heregulin) family of cytokines is comprised of multiple secreted or membrane-bound isorforms that are produced from the single heregulin gene by alternative splicing and/or usage of different promoters. NRG1 isoform SMDF is a type III isoform with a C-terminal EGF-like domain that interacts with the erbB family of tyrosine kinase receptors. NRG1 isoform SMDF expression has been found to be restricted to the nervous system and is believed to play an important role in the development of the nervous system.
Biochem/physiol Actions
ED?? = 1-5 ng/ml as measured in a serum-free proliferation assay using MCF-7 human breast adenocarcinoma cells.
NRG1 Isoform SMDF, Human, Recombinant Preparation Products And Raw materials
Raw materials
Preparation Products
NRG1 Isoform SMDF, Human, Recombinant Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
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Sigma-Aldrich | 80 |