SCOPARONE
- CAS No.
- 120-08-1
- Chemical Name:
- SCOPARONE
- Synonyms
- scoparon;SCOPARONE;escoparone;AKOS 236-43;SCOPARONE(RG);DIMETHYLESCULETIN;DIMETHOXYCOUMARIN;Scoparone 120-08-1;6,7-DIMETHYLESCULETIN;6,7-DIMETHOXYCOUMARIN
- CBNumber:
- CB3486326
- Molecular Formula:
- C11H10O4
- Molecular Weight:
- 206.19
- MDL Number:
- MFCD00006871
- MOL File:
- 120-08-1.mol
- MSDS File:
- SDS
| Melting point | 143-145 °C (lit.) |
|---|---|
| Boiling point | 265.04°C (rough estimate) |
| Density | 1.0858 (rough estimate) |
| refractive index | 1.4389 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | >8.4mg/mL in DMSO |
| form | Powder |
| Merck | 13,8479 |
| LogP | 1.331 (est) |
| CAS DataBase Reference | 120-08-1(CAS DataBase Reference) |
| FDA UNII | H5841PDT4Y |
| NIST Chemistry Reference | 2H-1-benzopyran-2-one, 6,7-dimethoxy-(120-08-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H319 | |||||||||
| Precautionary statements | P301+P310+P330-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 23/24/25-36-22 | |||||||||
| Safety Statements | 27/28-36/37/39-45-26 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GN6550000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29322090 | |||||||||
| NFPA 704 |
|
SCOPARONE price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 254886 | 6,7-Dimethoxycoumarin 98% | 120-08-1 | 250mg | $170 | 2024-03-01 | Buy |
| Sigma-Aldrich | 254886 | 6,7-Dimethoxycoumarin 98% | 120-08-1 | 1g | $377 | 2024-03-01 | Buy |
| Cayman Chemical | 20046 | Scoparone ≥98% | 120-08-1 | 10mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 20046 | Scoparone ≥98% | 120-08-1 | 25mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 20046 | Scoparone ≥98% | 120-08-1 | 50mg | $214 | 2024-03-01 | Buy |
SCOPARONE Chemical Properties,Uses,Production
Uses
Scoparone-13C2D6 is a by-product in the synthesis of Scopoletin-13C,d3 (S200502). Scopoletin-13C,d3, is the labeled analogue of Scopoletin (S200500), used for cosmetics, topical formulations, and foods. Scoparone-13C2D6 is also the labeled form of Scoparone (S199980), which regulates the expression of Th1/Th2 cytokines and IgE and is effective in treating allergic rhinitis.
Definition
ChEBI: Scoparone is a member of the class of coumarins that is esculetin in which the two hydroxy groups at positions 6 and 7 are replaced by methoxy groups. It is a major constituent of the Chinese herbal medicine Yin Chen Hao, and exhibits a variety of pharmacological activities such as anti-inflammatory, anti-allergic, and anti-tumor activities. It has a role as a plant metabolite, an anti-inflammatory agent, an antilipemic drug, an immunosuppressive agent, an antihypertensive agent and an anti-allergic agent. It is a member of coumarins and an aromatic ether. It is functionally related to an esculetin.
Synthesis Reference(s)
Synthesis, p. 1026, 1986 DOI: 10.1055/s-1986-31859
General Description
6,7-Dimethoxycoumarin inhibits the in vitro growth of Phytophthora citrophthora, Verticillium dahliae, Penicillium digitatum, P. italicum, Colletotrichum gloeosporioides, Diplodia natalensis and Hendersonula toruloidea. Determination and pharmacokinetic study of 6,7-dimethoxycoumarin in rat plasma after intragastric administration of different decoctions of Yinchenhao Tang by reversed-phase HPLC method with UV detection has been reported.
Safety Profile
Poison by ingestion and intraperitoneal routes. Experimental reproductive effects. An anthypertensive agent. When heated to decomposition it emits acrid smoke and irritating fumes.
SCOPARONE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 | sale02@cqherb.com | CHINA | 376 | 58 |
View Lastest Price from SCOPARONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-02-24 | 6,7-Dimethoxycoumarin
120-08-1
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2023-02-24 | 6,7-Dimethoxycoumarin
120-08-1
|
US $0.00 / mg | 5mg | Analytical Standard | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2023-02-13 | 6,7-Dimethoxycoumarin
120-08-1
|
US $80.00 / kg | 1kg | 99% | 100MT | Hebei baicao biology science and technology co., ltd |
-
- 6,7-Dimethoxycoumarin
120-08-1
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- 6,7-Dimethoxycoumarin
120-08-1
- US $0.00 / mg
- Analytical Standard
- Shanghai Standard Technology Co., Ltd.
-
- 6,7-Dimethoxycoumarin
120-08-1
- US $80.00 / kg
- 99%
- Hebei baicao biology science and technology co., ltd