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ChemicalBook >> CAS DataBase List >>Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate

Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate

Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate Structure
Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate structure
CAS No.
1256269-87-0
Chemical Name:
Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate
Synonyms
SAK3 >=98% (HPLC);Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate;Spiro[2-cyclopentene-1,3'(2'H)-imidazo[1,2-a]pyridine]-3-carboxylic acid, 8'-methyl-2',4-dioxo-2-(1-piperidinyl)-, ethyl ester
CBNumber:
CB34902723
Molecular Formula:
C20H23N3O4
Molecular Weight:
369.41
MDL Number:
MOL File:
1256269-87-0.mol
Last updated:2025-07-30 12:01:46
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Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate Properties

Boiling point 539.3±60.0 °C(Predicted)
Density 1.37±0.1 g/cm3(Predicted)
storage temp. Store at 4°C
solubility Soluble in DMSO
pka 3.36±0.20(Predicted)
form Solid
color White to off-white
FDA UNII YJ4M3A4ZH4
UNSPSC Code 12352200
NACRES NA.77

Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC S836043 SAK3 1256269-87-0 1mg $75 2021-12-16 Buy
Product number Packaging Price Buy
S836043 1mg $75 Buy

Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate Chemical Properties,Uses,Production

Uses

SAK3 is a potent CaV3.1 and CaV3.3 activator. Enhances CaV3.1 and CaV3.3, but not CaV3.2 activity at concentrations of 0.01 - 10 M in neuro2A cells in vitro. Elevates ACh levels in hippocampus. Rescues impaired memory-related behaviors in OBX mice. Orally bioavailable.

Biological Activity

SAK3 is a potent and orally active spiroimidazopyridine derivative th at enhances Cav3.1 and Cav3.3, but not Cav3.2, T-type voltage-gated Ca2+ channel (T-VGCC) activity (∼20% peak current increase with 0.1 nM SAK3 by whole-cell patch-clamp using human Cav3.1 or Cav3.3 transfected neuro2A; no effect up to 10 nM using Cav3.2 transfectant). Acute SAK3 oral administration (0.5 mg/kg) significantly enhances hippocampal CA1 region acetylcholine (ACh) release in na?ve mice, as well as increases hippocampal ACh levels and improves memory deficits among olfactory-bulbectomized (OBX) mice. Daily SAK3 oral administration 24 hrs following hypothyroidism induction by methimazole (MMI) is efficacious against MMI-induced medial septum (MS) cholinergic neurons loss (0.5-1 mg/kg/day) and cognitive deficits (1 mg/kg/day).

in vivo

Acute SAK3 (0.5 mg/kg) oral administration promotes acetylcholine (ACh) release in hippocampal CA1 via T-VGCC stimulation via enhancing T-type Ca2+ channel[1].

Animal Model:Animal Model:Cav3.1 knockout (KO) mice[1]
Dosage: 0.5 mg/kg
Administration:Administered p.o.
Result:Significantly increased ACh release in CA1, peaking at 20 min after oral administration.

IC 50

T-type calcium channel

storage

Store at +4°C

Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate Suppliers

Global( 18)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32376 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
HangZhou YuHao Chemical Technology Co., Ltd. 0571-82693216 info@yuhaochemical.com China 2028 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6777 58
BOC Sciences -- info@bocsci.com USA 0 65
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44813 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24982 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 5656 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Aladdin Scientific 		58
HangZhou YuHao Chemical Technology Co., Ltd. 58
Shanghai Hongye Biotechnology Co. Ltd 58
BOC Sciences 65
Energy Chemical 58
TargetMol Chemicals Inc. 58
Nantong QuanYi Biotechnology Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58

View Lastest Price from Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SAK3 pictures 2025-07-30 SAK3
1256269-87-0
 US $129.00-483.00 / mg 99.55% 10g TargetMol Chemicals Inc.
  • SAK3 pictures
  • SAK3
    1256269-87-0
  • US $129.00-483.00 / mg
  • 99.55%
  • TargetMol Chemicals Inc.
Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate SAK3 >=98% (HPLC) Spiro[2-cyclopentene-1,3'(2'H)-imidazo[1,2-a]pyridine]-3-carboxylic acid, 8'-methyl-2',4-dioxo-2-(1-piperidinyl)-, ethyl ester 1256269-87-0