NEMONAPRIDE
- CAS No.
- 75272-39-8
- Chemical Name:
- NEMONAPRIDE
- Synonyms
- C12915;Emilace;ym-09151;emonapride;YM 09151-2;NEMONAPRIDE;nobenzamide;inobenzamide;(2R,3R)-nemonapride;cis-(+-)-rrolidinyl)
- CBNumber:
- CB3492220
- Molecular Formula:
- C21H26ClN3O2
- Molecular Weight:
- 387.9
- MDL Number:
- MFCD00902138
- MOL File:
- 75272-39-8.mol
| Melting point | 152-153°C |
|---|---|
| storage temp. | Store at RT |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| CAS DataBase Reference | 75272-39-8 |
| FDA UNII | Q88T5P3444 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| NFPA 704 |
|
NEMONAPRIDE price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21376 | Nemonapride ≥98% | 75272-39-8 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 21376 | Nemonapride ≥98% | 75272-39-8 | 5mg | $140 | 2024-03-01 | Buy |
| Cayman Chemical | 21376 | Nemonapride ≥98% | 75272-39-8 | 10mg | $214 | 2024-03-01 | Buy |
| Cayman Chemical | 21376 | Nemonapride ≥98% | 75272-39-8 | 50mg | $844 | 2024-03-01 | Buy |
| Tocris | 1746 | Nemonapride ≥99%(HPLC) | 75272-39-8 | 10 | $212 | 2021-12-16 | Buy |
NEMONAPRIDE Chemical Properties,Uses,Production
Description
Nemonapride is a potent dopamine D2receptor antagonist antipsychotic reported to have superior efficacy against hallucinations and delusions and also to be effective in the treatment of negative symptoms. The compound is a benzamide diastereomer and, although more potent than haloperidol, side effects are reported to be few primarily akinesia and some muscle rigidity with extrapyramidal symptoms being rare.
Description
Nemonapride is an antipsychotic that readily passes through the blood brain barrier and exhibits potent neuroleptic effects in animals. It binds dopamine 2 (D2)-like receptors preferentially over D1-like receptors (Kis = 0.06, 0.3, and 0.15 nM for D2, D3, and D4, respectively). Nemonapride also binds sigma 1 (σ1) and σ2 receptors (Kis = 8.4 and 9.6 nM, respectively) and activates the serotonin 1A receptor (5-HT1A; IC50 = 34 nM).
Chemical Properties
Colourless Crystalline Solid
Originator
Yamanouchi (Japan)
Uses
Nemonapride is a selective dopamine D2 receptor antagonist. Nemonapride is used as an antipsychotic.
Uses
A selective dopamine D2 receptor antagonist. Used as an antipsychotic
Definition
ChEBI: (2R,3R)-nemonapride is an optically active form of nemonapride having (2R,3R)-configuration. It is a conjugate base of a (2R,3R)-nemonapride(1+). It is an enantiomer of a (2S,3S)-nemonapride.
brand name
Emirace
Biological Activity
Highly potent dopamine D 2 -like receptor antagonist; selective over D 1 -like receptors (K i values are 0.1 and 740 nM for D 2 -like and D 1 -like receptors respectively). Also potent 5-HT 1A receptor agonist (IC 50 = 34 nM) and has affinity for sigma receptors.
storage
Store at RT
NEMONAPRIDE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55672 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
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