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(-)-BICUCULLINE METHBROMIDE

(-)-BICUCULLINE METHBROMIDE Structure
(-)-BICUCULLINE METHBROMIDE structure
CAS No.
66016-70-4
Chemical Name:
(-)-BICUCULLINE METHBROMIDE
Synonyms
(-)-BICUCULLINE METHBROMIDE;1(S),9(R)-(-)-Bicuculline methbromide;1(s),9(r)-(-)-bicuculline methobromide;(6R)-6-[(5S)-6,6-dimethyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-ium-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one;[r-(r*,s*)]-5-(6,8-dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquindinium bromide;(5S)-5-[(6R)-6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide (1:1)
CBNumber:
CB3496965
Molecular Formula:
C21H20NO6.Br
Molecular Weight:
462.294
MDL Number:
MFCD00055149
MOL File:
66016-70-4.mol
Last updated:2023-06-30 15:45:59
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(-)-BICUCULLINE METHBROMIDE Properties

storage temp. 2-8°C
solubility aqueous base: unstable
form solid
color white
Water Solubility Soluble to 50 mM in water

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS06,GHS09
Signal word  Danger
Hazard statements  H300-H311+H331-H410
Precautionary statements  P273-P280-P301+P310+P330-P302+P352+P312-P304+P340+P311
Hazard Codes  T+,N
Risk Statements  24-28-50
Safety Statements  24/25-61-45-36/37-28
RIDADR  UN 1544 6.1/PG 2
WGK Germany  3

(-)-BICUCULLINE METHBROMIDE price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B7561 1(S),9(R)-(?)-Bicuculline methbromide ≥98% (HPLC), solid 66016-70-4 25mg $173 2024-03-01 Buy
Sigma-Aldrich B7561 1(S),9(R)-(?)-Bicuculline methbromide ≥98% (HPLC), solid 66016-70-4 125mg $724 2024-03-01 Buy
Product number Packaging Price Buy
B7561 25mg $173 Buy
B7561 125mg $724 Buy

(-)-BICUCULLINE METHBROMIDE Chemical Properties,Uses,Production

Uses

1(S),9(R)-(-)-Bicuculline methbromide has been used:

  • as a γ-aminobutyric acid (GABAA) receptor A antagonist: in cortical neuron culture
  • in artificial cerebrospinal fluid (ACSF) formature dentate granule neurons
  • in hypothalamic explant cultures

Biochem/physiol Actions

1(S),9(R)-(?)-Bicuculline methbromide is a GABAA receptor antagonist, which blocks Ca2+-activated potassium (SK) channels. It is the water-soluble derivative of (+)-bicuculline.

storage

Store at RT

(-)-BICUCULLINE METHBROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

(-)-BICUCULLINE METHBROMIDE Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 4028 58
Supplier Advantage
Aladdin Scientific 		58
Sigma-Aldrich 80
Nantong QuanYi Biotechnology Co., Ltd 58
(5S)-5-[(6R)-6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide (1:1) 1(S),9(R)-(-)-Bicuculline methbromide (-)-BICUCULLINE METHBROMIDE [r-(r*,s*)]-5-(6,8-dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquindinium bromide 1(s),9(r)-(-)-bicuculline methobromide (6R)-6-[(5S)-6,6-dimethyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-ium-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one 66016-70-4