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HUMULONE
- CAS No.
- 26472-41-3
- Chemical Name:
- HUMULONE
- Synonyms
- HUMULONE;α-bitter acid;[R,(-)]-Humulone;HUMULONE USP/EP/BP;Phloroglucinol Impurity T;(R)-Humulone DISCONTINUED;α-Bitter acid, α-Lupulic acid;Humulone, mixture of homologues;(6R)-3,5,6-trihydroxy-2-isovaleryl-4,6-bis(3-methylbut-2-enyl)cyclohexa-2,4-dienone;(6R)-4,6-Diprenyl-3,5,6-trihydroxy-2-(1-oxo-3-methylbutyl)-2,4-cyclohexadiene-1-one
- CBNumber:
- CB3497674
- Molecular Formula:
- C21H30O5
- Molecular Weight:
- 362.46
- MDL Number:
- MFCD00076002
- MOL File:
- 26472-41-3.mol
Last updated:2023-05-18 11:31:22
| Melting point | 65-66.5℃ |
|---|---|
| alpha | D20 -212° (1.0 g in 15.5 g 96% alc) |
| Boiling point | 414.06°C (rough estimate) |
| Density | 1.157±0.06 g/cm3 (20 ºC 760 Torr) |
| refractive index | 1.6120 (estimate) |
| storage temp. | −20°C |
| solubility | DMSO : 100 mg/mL (275.89 mM; Need ultrasonic) |
| form | Powder |
| pka | 4.50±1.00(Predicted) |
| FDA UNII | KHB4767H3K |
SAFETY
Risk and Safety Statements
| WGK Germany | 3 |
|---|---|
| F | 10-23 |
HUMULONE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth Carbosynth | FH65574 | Humulone | 26472-41-3 | 200ug | $160 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FH65574 | Humulone | 26472-41-3 | 500ug | $300 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FH65574 | Humulone | 26472-41-3 | 1mg | $450 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FH65574 | Humulone | 26472-41-3 | 2mg | $550 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FH65574 | Humulone | 26472-41-3 | 5mg | $700 | 2021-12-16 | Buy |
HUMULONE Chemical Properties,Uses,Production
Uses
(R)-Humulone (CAS# 26471-41-3) can be used as a chemosensory receptor ligand.
Definition
ChEBI: Humulone is an optically active cyclic ketone consisting of 3,5,6-trihydroxycyclohexa-2,4-dien-1-one bearing two 3-methylbut-2-en-1-yl substituents at positions 4 and 6 as well as a 3-methylbutanoyl group at the 2-position. It has a role as an antibacterial drug, an antioxidant, a cyclooxygenase 2 inhibitor and a metabolite. It is a diketone, a triol, a cyclic ketone, an aromatic ketone and a tertiary alpha-hydroxy ketone.
target
IL Receptor | AP-1 | COX | p65 | NF-kB | IkB | VEGFR | Antifection | IKK
Purification Methods
Crystallise humulon from Et2O. It dissolves slightly in hot H2O but precipitates on cooling. It has max () 237 (13,760) and 282 (8,330) in EtOH. [Wollmer Chem Ber 49 780 1916, Carson J Am Chem Soc 73 4652 1951, Beilstein 8 II 537, 8 III 4034, 8 IV 3410.]
Synthesis of HUMULONE from 2,4-Cyclohexadien-1-one, 3,5,6-trihydroxy-4,6-bis(3-methyl-2-buten-1-yl)-2-(3-methyl-1-oxobutyl)-
HUMULONE Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 44)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29067 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | sales@chem-strong.com | China | 17982 | 56 |
| Shanghai Yongye Biotechnology Co., Ltd. | 86-021-61559134 15921386130 | 3423497944@qq.com | China | 8147 | 55 |
26472-41-3(HUMULONE)Related Search:
(6R)-3,5,6-trihydroxy-2-isovaleryl-4,6-bis(3-methylbut-2-enyl)cyclohexa-2,4-dienone
α-bitter acid
Humulone, mixture of homologues
α-Bitter acid, α-Lupulic acid
(6R)-2-(3-Methylbutyryl)-3,5,6-trihydroxy-4,6-bis(3-methyl-2-butenyl)-2,4-cyclohexadiene-1-one
(6R)-4,6-Diprenyl-3,5,6-trihydroxy-2-(1-oxo-3-methylbutyl)-2,4-cyclohexadiene-1-one
[R,(-)]-3,5,6-Trihydroxy-4,6-bis(3-methyl-2-butenyl)-2-(3-methyl-1-oxobutyl)-2,4-cyclohexadien-1-one
[R,(-)]-Humulone
HUMULONE
(6S)-3,5,6-trihydroxy-2-(3-methylbutanoyl)-4,6-bis(3-methylbut-2-enyl)cyclohexa-2,4-dien-1-one
2,4-Cyclohexadien-1-one,3,5,6-trihydroxy-4,6-bis(3-methyl-2-buten-1-yl)-2-(3-methyl-1-oxobutyl)-, (6R)-
HUMULONE USP/EP/BP
(R)-Humulone
DISCONTINUED
Phloroglucinol Impurity T
(R)-3,5,6-Trihydroxy-4,6-bis(3-methylbut-2-en-1-yl)-2-(3-methylbutanoyl)cyclohexa-2,4-dienone
26472-41-3
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