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POLYTHIAZIDE (200 MG)

POLYTHIAZIDE (200 MG) structure

CAS No.: 346-18-9

Chemical Name:: POLYTHIAZIDE (200 MG)

Synonyms: p2525;P 2525;Renese;Nephril;Drenusil;NSC-108161;polythiazide;Drenusilnephril;POLYTHIAZIDE (200 MG);Polythiazide Solution, 100ppm

CBNumber:: CB3500394

Molecular Formula:: C11H13ClF3N3O4S3

Molecular Weight:: 439.8818296

MDL Number:: MFCD00072071

MOL File:: 346-18-9.mol

Last updated:2023-05-04 17:34:38

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POLYTHIAZIDE (200 MG) Properties

Melting point	202.5°
Boiling point	580.1±60.0 °C(Predicted)
Density	1.8346 (rough estimate)
refractive index	1.6100 (estimate)
storage temp.	Refrigerator
solubility	DMSO (Slightly), Methanol (Slightly, Heated)
pka	pKa 9.58(H2O,t =25) (Uncertain)
form	Solid
color	White to Off-White
FDA UNII	36780APV5N
ATC code	C03AA05
EPA Substance Registry System	Polythiazide (346-18-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P264-P270-P301+P312-P330-P501

POLYTHIAZIDE (200 MG) price More Price(8)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	P689410	Polythiazide	346-18-9	10mg	$215	2021-12-16	Buy
TRC	P689410	Polythiazide	346-18-9	100mg	$1695	2021-12-16	Buy
American Custom Chemicals Corporation	API0006930	POLYTHIAZIDE 95.00%	346-18-9	100MG	$1963.5	2021-12-16	Buy
Medical Isotopes, Inc.	61335	Polythiazide	346-18-9	100mg	$2400	2021-12-16	Buy
Medical Isotopes, Inc.	61335	Polythiazide	346-18-9	10mg	$675	2021-12-16	Buy

Product number	Packaging	Price	Buy
P689410	10mg	$215	Buy
P689410	100mg	$1695	Buy
API0006930	100MG	$1963.5	Buy
61335	100mg	$2400	Buy
61335	10mg	$675	Buy

POLYTHIAZIDE (200 MG) Chemical Properties,Uses,Production

Description

Polythiazide exhibits a more pronounced antihypertensive effect than chlorothiazide and it may be used independently for the same indications as the aforementioned drugs. However, it is primarily used as an ingredient of a combination drugs intended for lowering pressure, in particular in minizide, which is a combination of prazozine and polythiazide.

Originator

Renese ,Pfizer, US ,1961

Uses

Polythiazide is a thiazide diuretic. Polythiazide is used in the treatment of hypertension as well as nephrotic syndrome, cirrhosis of the liver, and nutritional edema.

Definition

ChEBI: Polythiazide is a benzothiadiazine.

Manufacturing Process

(A) Preparation of trifluoroethylthioacetaldehyde dimethylacetal: To 4.6 g (0.2 mol) of metallic sodium dissolved in 75 ml of absolute methanol is rapidly added 24.4 g (0.2 mol) of mercaptoacetaldehyde dimethylacetal followed by dropwise addition of 42.0 g (0.2 mol) of trifluoroethyl iodide.
The resulting reddish mixture is refluxed on a steam bath for one hour. One half of the alcohol is removed by concentration and the remainder diluted with several volumes of water and extracted with ether. The combined ether extracts are dried over sodium sulfate, the ether then removed at reduced pressure and the residue distilled to about 30 g (BP 82°C/25 mm).
(B) Preparation of 4-Amino-2-Chloro-5-(Methylsulfamyl)Benzenesulfonamide: The 5-substituted-2,4-disulfamyl anilines may be prepared by procedures described in the literature, for example, the general procedures in Monatsch. Chem. vol. 48, p 87 (1927), which involves the treatment of a m-substituted aniline with from 10 to 20 parts by weight of chlorosulfonic acid followed by the gradual addition of from about 90 to 170 parts by weight of sodium chloride. The resultant mixture is heated at approximately 150°C for about 2hours after which the reaction mixture is poured into water and the resultant 5substituted aniline-2,4-disulfonyl chloride is filtered and is then treated with concentrated ammonium hydroxide or suitable amine by standard procedures to obtain the corresponding disulfonamide.
(C) Preparation of 2-Methyl-3-(2,2,2-Trifluoroethyl)Thiomethyl-6-Chloro-7Sulfamyl-3,4-Dihydro-1,2,4-Benzothiadiazine-1,1-Dioxide: To 4.6 g (0.015 mol) of 4-amino-2-chloro5-(methylsulfamyl)benzenesulfonamide in 30 ml of the dimethyl ether of ethylene glycol is added 4.08 g (0.02 mol) of 2,2,2trifluoroethylmercaptoacetaldehyde dimethylacetal followed by 1 ml of ethyl acetate saturated with hydrogen chloride gas. The resulting solution is refluxed for 1.5 hours, cooled and then slowly added to cold water dropwise with stirring. The crude product is filtered, dried and recrystallized from isopropanol (3.2 g), MP 202° to 202.5°C. A second recrystallization from isopropanol raised the MP to 202° to 203°C.

brand name

Renese (Pfizer).

Therapeutic Function

Diuretic

General Description

Crystals or white powder.

Air & Water Reactions

Its rate of decomposition in solution increases with an increase in pH. . Insoluble in water.

Reactivity Profile

POLYTHIAZIDE (200 MG) is a sulfonamide derivative. With strong reducing agents will produce hydrogen sulfide gas.

Fire Hazard

Flash point data for POLYTHIAZIDE (200 MG) are not available, but POLYTHIAZIDE (200 MG) is probably combustible.

Synthesis

Polythiazide, 1,1-dioxide 2-methyl-3-(2,2,2-trifluoroethylthiomethyl)-6- chloro-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-sulfonamide (21.3.8), is also synthesized by an analogous scheme, which is by condensing 4-aminosulfonyl-5-chloro-2-methylaminosulfonylaniline (21.3.7) with 2,2,2-trifluoroethylthioacetaldehyde dimethylacetal.

Synthesis_346-18-9

POLYTHIAZIDE (200 MG) Preparation Products And Raw materials

Raw materials

METHYCLOTHIAZIDE RELATED COMPOUND A (100 MG) (4-AMINO-6-CHLORO-N-3-METHYL-M-BEN-ZENEDISULFONAMIDE) 2-Iodo-1,1,1-trifluoroethane 2,2-dimethoxyethanethiol Sodium

Preparation Products

POLYTHIAZIDE (200 MG) Suppliers

Global( 37)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569265 +86-18612256290	1056@dideu.com	China	3759	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29423	58
Shaanxi Didu New Materials Co. Ltd	+86-89586680 +86-13289823923	1026@dideu.com	China	9264	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32344	50
HBCChem, Inc.	+1-510-219-6317	sales@hbcchem.com	United States	10658	60
Alta Scientific Co., Ltd.	022-6537-8550 15522853686	sales@altasci.com.cn	China	4515	55

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Career Henan Chemica Co	58
Dideu Industries Group Limited	58
Shaanxi Didu New Materials Co. Ltd	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
TargetMol Chemicals Inc.	58
J & K SCIENTIFIC LTD.	76
Chemsky（shanghai）International Co.,Ltd.	50
HBCChem, Inc.	60
Alta Scientific Co., Ltd.	55

View Lastest Price from POLYTHIAZIDE (200 MG) manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-20	Polythiazide 346-18-9	US $1.00-1.00 / KG	1g	99%	50tons	Shaanxi Dideu Medichem Co. Ltd
	2021-07-09	POLYTHIAZIDE (200 MG) USP/EP/BP 346-18-9	US $1.10 / g	1g	99.9%	100 Tons Min	Dideu Industries Group Limited

Polythiazide
346-18-9
US $1.00-1.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

POLYTHIAZIDE (200 MG) USP/EP/BP
346-18-9
US $1.10 / g
99.9%
Dideu Industries Group Limited

346-18-9(POLYTHIAZIDE (200 MG))Related Search:

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1of3

2h-1,2,4-benzothiadiazine-7-sulfonamide,6-chloro-3,4-dihydro-2-methyl-3-(((2,2 2h-benzo-1,2,4-thiadiazine1,1-dioxide 2-methyl-3-(beta,beta,beta-trifluoroethylthiomethyl)-6-chloro-7-sulfamyl-3,4-d 6-Chloro-2-methyl-3-([(2,2,2-trifluoroethyl)sulfanyl]methyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide 6-Chloro-3,4-dihydro-2-methyl-3-(((2,2,2-trifluoroethyl)thio)methyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide 6-Chloro-3,4-dihydro-2-methyl-3-[[(2,2,2-trifluoromethyl)thio]methyl]-2H-1,2,4-benzothiadiazine -7-sulfonamide 1,1-dioxide benzothiadiazine-7-sulfonamide1,1-dioxide Drenusil Drenusilnephril ihydro-1,2,4-benzothiadiazine1,1-dioxide Nephril NSC-108161 P 2525 6-Chloro-3,4-dihydro-2-Methyl-3-[[2,2,2-trifluoroethyl)thio]Methyl]-2H-1,2,4-benzothiadiazine-7-sulfonaMide 1,1-Dioxide 6-Chloro-3,4-dihydro-2-Methyl-7-sulfaMoyl-3-(2,2,2-trifluoroethylthioMethyl)-2H-1,2,4-benzothiadiazine 1,1-Dioxide ,2-trifluoroethyl)thio)methyl)-,1,1-dioxide 2,2-trifluoroethyl)thio)methyl)-,1,1-dioxide 2,2-trifluoroethyl)thio]methyl]-2h-1,2,4-6-chloro-4-dihydro-2-methyl-3-[[(2 2,2-trifluoroethylthiomethyl)-6-chloro-4-dihydro-2-methyl-7-sulphamoyl-3-(2 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-2-methyl-3-[[(2,2,2-trifluoroethyl)thio]methyl]-, 1,1-dioxide 2h-1,2,4-benzothiadiazine-7-sulfonamide,6-chloro-3,4-dihydro-2-methyl-3-(((2, p2525 polythiazide Renese POLYTHIAZIDE (200 MG) 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-2-methyl-3-(2,2,2-trifluoroethyl)thiomethyl-, 1,1-dioxide 6-chloro-1,1-diketo-2-methyl-3-[(2,2,2-trifluoroethylthio)methyl]-3,4-dihydrobenzo[e][1,2,4]thiadiazine-7-sulfonamide 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydrobenzo[e][1,2,4]thiadiazine-7-sulfonamide Polythiazide Solution, 100ppm POLYTHIAZIDE (200 MG) USP/EP/BP 346-18-9 C11H13ClF3N3O4S3