ISOCARBOXAZID (200 MG)
- CAS No.
- 59-63-2
- Chemical Name:
- ISOCARBOXAZID (200 MG)
- Synonyms
- isocarboxazid;Isocarboxazide;Marplan;Bmih;Enerzer;Marplon;Benazide;Maraplan;ro5-0831;Ro 5-0831
- CBNumber:
- CB3500536
- Molecular Formula:
- C12H13N3O2
- Molecular Weight:
- 231.25
- MDL Number:
- MFCD00865409
- MOL File:
- 59-63-2.mol
- MSDS File:
- SDS
| Melting point | 98-1000C |
|---|---|
| Boiling point | 373.33°C (rough estimate) |
| Density | 1.206 |
| refractive index | 1.5290 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | Acetonitrile: Slightly Soluble; Chloroform: Slightly Soluble |
| form | A solid |
| pka | pKa 10.4 (Uncertain) |
| Water Solubility | 0.8g/L(25 ºC) |
| EWG's Food Scores | 1 |
| FDA UNII | 34237V843T |
| ATC code | N06AF01 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P405-P501 | |||||||||
| RIDADR | 3249 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2934990002 | |||||||||
| NFPA 704 |
|
ISOCARBOXAZID (200 MG) price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS020459 | Isocarboxazid 5-methyl-3-isoxazole-carboxylic acid 2-benzylhydrazide AldrichCPR | 59-63-2 | 10MG | $68.1 | 2023-06-20 | Buy |
| Sigma-Aldrich | 1348000 | Isocarboxazid United States Pharmacopeia (USP) Reference Standard | 59-63-2 | 200MG | $402 | 2022-05-15 | Buy |
| Cayman Chemical | 23625 | Isocarboxazid ≥98% | 59-63-2 | 5mg | $34 | 2024-03-01 | Buy |
| Cayman Chemical | 23625 | Isocarboxazid ≥98% | 59-63-2 | 10mg | $64 | 2024-03-01 | Buy |
| Cayman Chemical | 23625 | Isocarboxazid ≥98% | 59-63-2 | 25mg | $117 | 2024-03-01 | Buy |
ISOCARBOXAZID (200 MG) Chemical Properties,Uses,Production
Chemical Properties
Pale Yellow Solid
Originator
Marplan,Roche,US,1959
Uses
Isocarboxazid is a powerful MAO inhibitor. As with phenelzine, isocarboxazid is used for depressions that do not respond to other drugs.
Uses
Monoamine oxidase inhibitor. Antidepressant
Definition
ChEBI: 5-methyl-N'-(phenylmethyl)-3-isoxazolecarbohydrazide is a member of benzenes.
Manufacturing Process
800 g of benzaldehyde was added to a hot solution (75°C) of 7 liters of
ethanol containing 720 g of 5-methyl-2-isoxazole carboxylic acid hydrazide.
The solution was stirred for ten minutes at which time the product began to
crystallize. On cooling at 4°C for 14 hours, the solid was filtered off under
vacuum and the solid filter cake was washed twice using 250 ml of ice cold
ethanol for each washing. The lbenzylidene-2-(5-methyl-3-isoxazolylcarbonyl)
hydrazine was recrystallized from ethanol, MP 199°C to 200°C.
115 g of 1-benzylidene-2-(5-methyl-3-isoxazolylcarbonyl)hydrazine was added
portionwise over the period of an hour to 5 liters of anhydrous ether
containing 18.5 g of lithium aluminum hydride. The reaction mixture was
stirred for four hours and permitted to stand overnight. The excess lithium
aluminum hydride was decomposed with 250 ml of ethyl acetate and 150 ml
of water was added to decompose the complex. The solid was separated by
filtration and the ether layer was concentrated to about 500 mi. 200 ml of
benzene was added to dehydrate the solution. Concentration was continued
until a solid remained. The 1-benzyl-2-(5-methyl-3-isoxazolylcarbonyl)
hydrazine was recrystallized from methanol, MP 105°C to 106°C.
brand name
Marplan (Oxford).
Therapeutic Function
Antidepressant
World Health Organization (WHO)
Isocarboxazid, a monoamine oxidase inhibitor (MAOI), was introduced in 1959 for the treatment of depressive illness. Subsequently concern regarding potentially serious interactions between MAOIs and foods containing tyramine inspired much restrictive regulatory action. However, MAOIs still retain a place in the treatment of serious depressive illness although there is no international consensus on which compounds should be preferred. Thus isocarboxazid remains available in several countries and is cited in the British National Formulary as a relatively safe example of this class of compound.
Synthesis
Isocarboxazid, 2-benzylhydrazid-5-methyl-3-isoxazolecarboxylate (7.2.6), can be synthesized from acetylacetone, which on nitrosation with nitrous acid gives 5- methyl-isoxazol-3-carboxylic acid (7.2.2). Esterification of this product gives the ethyl ester of 5-methyl-isoxazol-3-carboxylic acid (7.2.3). The synthesized ester (7.2.3) is further reacted with benzylhydrazine, to give isocarboxazide (7.2.6), or with hydrazine, which forms 5-methyl-isoxazol-3-carboxylic acid hydrazide (7.2.4). Reacting the latter with benzaldehyde gives hydrazone (7.2.5), which is further reduced to the isocarboxazide (7.2.6) [46,47].
ISOCARBOXAZID (200 MG) Preparation Products And Raw materials
ISOCARBOXAZID (200 MG) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9116 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Mainchem Co., Ltd. | -- | sarah@mainchem.com | China | 6572 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
View Lastest Price from ISOCARBOXAZID (200 MG) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-27 | ISOCARBOXAZID (200 MG) USP/EP/BP
59-63-2
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited |
-
- ISOCARBOXAZID (200 MG) USP/EP/BP
59-63-2
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
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