AZATADINE MALEATE (200 MG)
- CAS No.
- 3978-86-7
- Chemical Name:
- AZATADINE MALEATE (200 MG)
- Synonyms
- Zadine;idulian;sch10649;optimine;idinedimaleate;azatadinemaleate;Einecs 223-615-8;azatadinedimaleate;AZATADINE MALEATE (200 MG);AZATADINE MALEATE USP/EP/BP
- CBNumber:
- CB3501391
- Molecular Formula:
- C28H30N2O8
- Molecular Weight:
- 522.5464
- MDL Number:
- MFCD00242593
- MOL File:
- 3978-86-7.mol
- MSDS File:
- SDS
| Melting point | 152-154° |
|---|---|
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| FDA UNII | F3Q391WTX7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319-H332-H317-H312 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501-P264-P280-P305+P351+P338-P337+P313P-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P261-P271-P304+P340-P312 | |||||||||
| HS Code | 2933399090 | |||||||||
| NFPA 704 |
|
AZATADINE MALEATE (200 MG) price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29758 | Azatadine (maleate) | 3978-86-7 | 50mg | $61 | 2024-03-01 | Buy |
| Cayman Chemical | 29758 | Azatadine (maleate) | 3978-86-7 | 100mg | $107 | 2024-03-01 | Buy |
| Cayman Chemical | 29758 | Azatadine (maleate) | 3978-86-7 | 250mg | $190 | 2024-03-01 | Buy |
| Cayman Chemical | 29758 | Azatadine (maleate) | 3978-86-7 | 500mg | $351 | 2024-03-01 | Buy |
| TRC | A802950 | AzatadineDimaleate | 3978-86-7 | 500mg | $270 | 2021-12-16 | Buy |
AZATADINE MALEATE (200 MG) Chemical Properties,Uses,Production
Chemical Properties
White Solid
Originator
Idulian,Unilabo,France,1968
Uses
Antihistaminic.
Definition
ChEBI: The dimaleate salt of azatadine.
Manufacturing Process
Preparation of 4-aza-5-(N-methyl-4-piperidyl)-10,11-dihydro-5Hdibenzo[
a,d]cycloheptene-5-ol: Add 17.4 g of N-methyl-4-chloropiperidine to a
stirred mixture containing 3.2 g of magnesium, 20 ml of anhydrous
tetrahydrofuran, 1 ml of ethyl bromide and a crystal of iodine. Reflux for two
hours, cool to 30-35°C and add a solution of 13 g of 4-aza-10,11-dihydro-5Hdibenzo[
a,d]cycloheptene-5-one in 25 ml of tetrahydrofuran. Stir for five
hours, remove the solvent by distillation in vacuum and add 250 ml of ether.
Add 100 ml of 10% ammonium chloride solution and extract the mixture with
chloroform. Concentrate the chloroform solution to a residue and recrystallize
from isopropyl ether obtaining 20 g of the carbinol, MP 173-174°C.
Preparation of 4-aza-5-(N-methyl-4-piperidylidene)-10,11-dihydro-5Hdibenzo[
a,d]cycloheptene: Heat 5.4 g of the carbinol and 270 g of
polyphosphoric acid for 12 hours at 140-170°C. Pour into ice water and make
alkaline with sodium hydroxide. Extract with ether. Dry ether solution and
concentrate to a residue. Crystallize from isopropyl ether, MP 124-126°C.
Preparation of 4-aza-5-(N-methyl-4-piperidylidene)-10,11-dihydro-5Hdibenzo[
a,d]cycloheptene dimaleate: To a solution containing 4.3 g of 4-aza-
(N-methyl-4-piperidylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene in 55
ml of ethyl acetate, add a solution of 3.45 g of maleic acid dissolved in ethyl
acetate. Filter the resulting precipitate and recrystallize the desired product
from an ethyl acetate-methanol mixture to yield 4-aza-5-(N-methyl-4-
piperidylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene dimaleate, MP
152-154°C.
brand name
Optimine (Schering);Verban.
Therapeutic Function
Antihistaminic
General Description
Azatadine maleate, 6,11-dihydro-11-(l-methyl-4-piperidylidene)-5H-benzo-[5,6]cyclo-hepta(1,2-b]pyridine maleate (1:2) (Optimine), is a potent,long-acting antihistaminic with antiserotonin activity. Inearly testing, azatadine exhibited more than three times thepotency of chiorpheniramine in the isolated guinea pigileum screen and more than seven times the oral potency ofchlorpheniramine in protection of guinea pigs against a doublelethal dose of intravenously administered histamine.
AZATADINE MALEATE (200 MG) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3683 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9409 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29322 | 58 |
View Lastest Price from AZATADINE MALEATE (200 MG) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-20 | Azatadine DiMaleate
3978-86-7
|
US $1.00-1.00 / KG | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2021-07-13 | AZATADINE MALEATE
3978-86-7
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-09 | AZATADINE MALEATE
3978-86-7
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Azatadine DiMaleate
3978-86-7
- US $1.00-1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- AZATADINE MALEATE
3978-86-7
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- AZATADINE MALEATE
3978-86-7
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd