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OXIDIZED NIFEDIPINE

OXIDIZED NIFEDIPINE Structure
OXIDIZED NIFEDIPINE structure
CAS No.
67035-22-7
Chemical Name:
OXIDIZED NIFEDIPINE
Synonyms
B 4759;BAY-b-4759;Nifedipine-1;Dehydro Nifedipine;NIFEDIPINE EP IMP A;Nifidipine Impurity A;Nitrophenyl nifedipine;Nifedipine impurity A CRS;Nifedipine impurity A (EP);Divalproex Sodium Impurity 1
CBNumber:
CB3505238
Molecular Formula:
C17H16N2O6
Molecular Weight:
344.32
MDL Number:
MFCD00153847
MOL File:
67035-22-7.mol
MSDS File:
SDS
Last updated:2025-10-29 15:43:00
Product description Number Pack Size Price
Oxidized Nifedipine powder, ~95% (HPLC) UC167 5mg $482
Nifedipine Nitrophenylpyridine Analog certified reference material, pharmaceutical secondary standard PHR3778 50MG $541
Nifedipine impurity A European Pharmacopoeia (EP) Reference Standard N0750010 25 mg $156
Nifedipine Nitrophenylpyridine Analog United States Pharmacopeia (USP) Reference Standard 1463600 25mg $1330
Dehydro Nifedipine ≥98% 23229 1mg $44
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OXIDIZED NIFEDIPINE Properties

Melting point 100-105 °C
Boiling point 443.7±45.0 °C(Predicted)
Density 1.284±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
form powder
pka 1.55±0.29(Predicted)
color yellow
FDA UNII OR3W8GT1C8
EPA Substance Registry System 3,5-Pyridinedicarboxylic acid, 2,6-dimethyl-4-(2-nitrophenyl)-,3,5-dimethyl ester (67035-22-7)
UNSPSC Code 41116107
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS05
Signal word  Danger
Hazard statements  H318
Precautionary statements  P280-P305+P351+P338+P310
Hazard Codes  Xi
Risk Statements  41
Safety Statements  26-39
WGK Germany  2
NFPA 704
0
3 0

OXIDIZED NIFEDIPINE price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich UC167 Oxidized Nifedipine powder, ~95% (HPLC) 67035-22-7 5mg $482 2025-07-31 Buy
Sigma-Aldrich PHR3778 Nifedipine Nitrophenylpyridine Analog certified reference material, pharmaceutical secondary standard 67035-22-7 50MG $541 2025-07-31 Buy
Sigma-Aldrich N0750010 Nifedipine impurity A European Pharmacopoeia (EP) Reference Standard 67035-22-7 25 mg $156 2025-07-31 Buy
Sigma-Aldrich 1463600 Nifedipine Nitrophenylpyridine Analog United States Pharmacopeia (USP) Reference Standard 67035-22-7 25mg $1330 2025-07-31 Buy
Cayman Chemical 23229 Dehydro Nifedipine ≥98% 67035-22-7 1mg $44 2024-03-01 Buy
Product number Packaging Price Buy
UC167 5mg $482 Buy
PHR3778 50MG $541 Buy
N0750010 25 mg $156 Buy
1463600 25mg $1330 Buy
23229 1mg $44 Buy

OXIDIZED NIFEDIPINE Chemical Properties,Uses,Production

Description

Dehydro nifedipine is an active metabolite of nifedipine , a calcium channel blocker present in formulations used to treat hypertension and angina. Dehydro nifedipine is formed when nifedipine is metabolized by the cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5. Dehydro nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM.

Chemical Properties

Pale Yellow Solid

Uses

Oxidized nifedipine has been used for apoptotic signaling studies in dopaminergic neurons.

Uses

The main Nifedipine metabolite in human plasma

Definition

ChEBI: Dehydronifedipine is a phenylpyridine.

Biochem/physiol Actions

CYP3A4 nifedipine metabolite. Nifedipine (parent compound) is an antianginal and antihypertensive agent.

References

[1] T. D. ARDIZZONE D D Xiao Hong Lu. Calcium-independent inhibition of glucose transport in PC-12 and L6 cells by calcium channel antagonists.[J]. American journal of physiology. Cell physiology, 2002, 27 1: C579-86. DOI: 10.1152/ajpcell.00451.2001
[2] KIRAN C PATKI D J G Lisa L Von Moltke. In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5.[J]. Drug Metabolism and Disposition, 2003, 31 7: 938-944. DOI: 10.1124/dmd.31.7.938
[3] TETSURO AGO. Nifedipine inhibits cardiac hypertrophy and left ventricular dysfunction in response to pressure overload.[J]. Journal of Cardiovascular Translational Research, 2010, 3 4: 304-313. DOI: 10.1007/s12265-010-9182-x
[4] J. LEMAY. Regression of Neointimal Lesions in the Carotid Artery of Nifedipine-Treated SHR and WKY Rats: Possible Role of Apoptosis[J]. Journal of Vascular Research, 2001, 38 1: 462-470. DOI: 10.1159/000051079

OXIDIZED NIFEDIPINE Preparation Products And Raw materials

Raw materials

Preparation Products

OXIDIZED NIFEDIPINE Suppliers

Global( 139)Suppliers
Supplier Tel Email Country ProdList Advantage
Moxin Chemicals 		+86-17320513646 +8617320513646 anna@molcoo.com China 10000 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81148696 +86-17392712697 1022@dideu.com China 3996 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32435 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30229 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23541 58
CR Corporation Limited 		+8613062833949 fred.wen@crcorporation.cn China 8647 58
Hangzhou Huarong Pharm Co., Ltd. 		571-86758373 +8613588754946 sales@huarongpharm.com CHINA 3148 58
sgtlifesciences pvt ltd 		+8617013299288 dj@sgtlifesciences.com China 12373 58
Supplier Advantage
Moxin Chemicals 		58
Accela ChemBio Inc. 		58
Standardpharm Co. Ltd. 		58
Shaanxi Dideu Medichem Co. Ltd 		58
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
ANHUI WITOP BIOTECH CO., LTD 		58
CR Corporation Limited 		58
Hangzhou Huarong Pharm Co., Ltd. 		58
sgtlifesciences pvt ltd 		58

View Lastest Price from OXIDIZED NIFEDIPINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Dehydro Nifedipine pictures 2025-09-29 Dehydro Nifedipine
67035-22-7
 US $42.00-147.00 / mg 99.19% 10g TargetMol Chemicals Inc.
Nifedipine EP Impurity A pictures 2025-07-31 Nifedipine EP Impurity A
67035-22-7
 US $0.00-0.00 / mg 10mg 99%+ HPLC 1000 Moxin Chemicals
Oxidized Nifedipine pictures 2019-12-29 Oxidized Nifedipine
67035-22-7
 US $0.10 / KG 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd

OXIDIZED NIFEDIPINE Spectrum

OXIDIZED NIFEDIPINE(67035-22-7)1HNMR

67035-22-7(OXIDIZED NIFEDIPINE)Related Search:

Nifedipine METHYL 2-(O-NITROBENZYLIDENE)-ACETOACETATE Methyl 3-aminocrotonate 2,6-Ntp Dehydro Nifedipine N-Oxide
diethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Nifedipine Impurity J Hydroxydehydro Nifedipine Carboxylate methyl 2,4-bis{2-nitrophenyl}-6-methyl-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate Nifedipine Impurity 9
2,6-DIMETHYL-4-(3-NITRO-PHENYL)-PYRIDINE-3,5-DICARBOXYLIC ACID DIMETHYL ESTER Nifendipine Impurity G nifedipine iMpurity C Hydroxy Dehydro Nifedipine Lactone 3-aminocrotonamide
Nifedipine impurity 10 Nifedipine EP IMpurity-B Nifedipine EP IMpurity-C

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Nifedipine Nitrophenylpyridine Analog dimethyl 2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate dimethyl2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate 2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3,5-Dimethyl Ester B 4759 Dehydro Nifedipine 2,6-Dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylic acid dimethyl ester 4-(2-Nitrophenyl)-2,6-dimethylpyridine-3,5-dicarboxylic acid dimethyl ester BAY-b-4759 Nitrophenyl nifedipine Nifedipine-1 Dimethyl 2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridined Nifedipine Impurity Ⅰ:2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3,5-Dimethyl Ester 2,6-Dimethyl-4-(2′-nitrophenyl)-3,5-pyridinecarboxylic acid dimethyl ester, Oxidized Nifedipine Divalproex Sodium Impurity 1 Nifedipine impurity A (EP) Dimethyl 4-(2-nitrophenyl)-2,6-dimethylpyridine-3,5-dicarboxylate Nifedipine Impurity Ⅰ（Dimethyl 2,6-Dimethyl-4-(2-Nitrophenyl)pyridine-3,5-Dicarboxylate） Nifedipine impurity A CRS Dimethyl 2,6-Dimethyl-4-(2-nitrophe Nifedipine EP Impurity A/Dehydro Nifedipine 3,5-Pyridinedicarboxylic acid, 2,6-dimethyl-4-(2-nitrophenyl)-, 3,5-dimethyl ester Nifidipine Impurity A Nifedipine EP Impurity A (Nifedipine nitrophenylpyridine analogue) Azilsartan medoxomil impurity308 DehydronifedipineQ: What is Dehydronifedipine Q: What is the CAS Number of Dehydronifedipine Q: What is the storage condition of Dehydronifedipine Q: What are the applications of Dehydronifedipine Nifedipine nitrophenylpyridine Analogue dimethyl 2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate (nitrophenylpyridine analogue) _x000b_Dimethyl 2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridined NIFEDIPINE EP IMP A Dehydronifedipine in Acetonitrile Nifedipine EP impurity A Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5- dicarboxylate (nitrophenylpyridine analogue) Dimethyl 2,6-Dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate (Nitrophenylpyridine Analogue of N Dimethyl 2,6-Dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate (Nitrophenylpyridine Analogue of Nifedipine) Dehydronifedipine 100 μg/mL in Acetonitrile 67035-22-7 34432 Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Various Metabolites and Impurities