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4-AMINOPHENYL-1-PHENETHYLPIPERIDINE

CAS No.
21409-26-7
Chemical Name:
4-AMINOPHENYL-1-PHENETHYLPIPERIDINE
Synonyms
4-ANPP;Fentanyl Related Compound E;TBC-5487;4-ANPP (CRM);4-ANPP solution;Depropionylfentanyl;Fentanyl Impurity D;Fentanyl Citrate EP Impurity D;Fentanyl Related CoMpound E CII;Fentanyl USP Related Compound E
CBNumber:
CB3506659
Molecular Formula:
C19H24N2
Molecular Weight:
280.41
MDL Number:
MFCD00179023
MOL File:
21409-26-7.mol
Last updated:2023-06-08 09:02:52

4-AMINOPHENYL-1-PHENETHYLPIPERIDINE Properties

Melting point 94-96°C
Boiling point 172-176 °C(Press: 0.15 Torr)
Density 1.075±0.06 g/cm3(Predicted)
Flash point 9°C
storage temp. Hygroscopic, -20°C Freezer, Under Inert Atmosphere
form Off-white solid.
pka 9.03±0.10(Predicted)
FDA UNII Q88EHD0U8G

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H300+H310+H330
Precautionary statements  P260-P262-P280-P301+P330+P331+P310-P302+P352+P310-P304+P340+P310
Risk Statements  22-36/37/38
Safety Statements  22-37/39-46
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  2
HS Code  29333990
DEA Controlled Substances CSCN: 8333
CSA SCH: Schedule II
NARC: No
NFPA 704
3
0 0

4-AMINOPHENYL-1-PHENETHYLPIPERIDINE Chemical Properties,Uses,Production

Description

4-ANPP (Item No. 18810) is an analytical reference material categorized as an opioid metabolite and a precursor in the synthesis of fentanyl (Item Nos. ISO60197 | 22659 | 14719) and other opioids. 4-ANPP is a metabolite of acetyl fentanyl (Item Nos. ISO60128 | ISO00128), butyryl fentanyl (Item Nos. 19734 | 14728), furanyl fentanyl (Item Nos. 19633 | 18705), acrylfentanyl (Item Nos. 23060 | 19312), and fentanyl. It has also been found as an impurity in illicit fentanyl preparations. 4-ANPP is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.

Description

4-ANPP (CRM) (Item No. 22700) is a certified reference material that is categorized as a piperidinamine. It is an intermediate in the synthesis of fentanyl (Item Nos. 22659 | 14719 | ISO60197) from N-phenethyl-4-piperidone (NPP; ). As such, 4-ANPP has been used as a precursor for the manufacture of fentanyl and related opioids. 4-ANPP is also an impurity found in fentanyl preparations. It is a known metabolite of acetyl fentanyl (Item Nos. ISO00128 | ISO60128), butyryl fentanyl (Item Nos. 14728 | 19734), furanyl fentanyl (Item Nos. 18705 | 19633), acrylfentanyl , and fentanyl. 4-ANPP is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.

Chemical Properties

Pale Yellow Solid

Uses

A 3H-Fentanyl (F274990) metabolite

4-AMINOPHENYL-1-PHENETHYLPIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

N-PHENYL-1-(2-PHENYLETHYL) PIPERIDIN-4-AMINE (1-PHENETHYL-PIPERIDIN-4-YL)-PHENYL-AMINE N-Phenyl-1-(2-phenethyl)piperidin-4-amine N-(1-PHENETHYL-PIPERIDIN-4-YL)-ANILINE 4-Piperidinamine, N-phenyl-1-(2-phenylethyl)- N-Phenyl-N’-[1-(2-phenylethyl)]-4-piperidine Discontinued See: A625875 N-[1-(2-Phenylethyl)-4-piperidinyl]benzenamine N-Phenyl-1-(2-phenylethyl)-4-piperidinamine Fentanyl Related Compound E CII (10 mg) (N-Phenyl-1-(2-phenylethyl)-4-piperidinamine) 1-Phenethyl-N-phenylpiperidin-4-aMine Depropionylfentanyl N-[1-(2-Phenylethyl)-4-piperidinyl]aniline TBC-5487 N-(1-phenyl-piperidin-4-yl)-aniline Fentanyl Related CoMpound E CII 4-ANPP solution 4-ANPP (CRM) 2-phenyl-1-(2-phenylethyl)-4-piperidinamine 4-Aminophenyl-1-phenethylpiperidine (100 μg/mL in Methanol) 1-(b-Phenethyl)-4-anilinopiperidine Fentanyl Related Compound E CII (N-Phenyl-1-(2-phenylethyl)-4-piperidinamine) (1269957) Fentanyl Related Compound E 4-ANPP Fentanyl USP Related Compound E 4-AMinophenyl-1-phenethylpiperidine (Fentanyl IMpurity) Fentanyl Citrate ImpurityⅠ:4-AMINOPHENYL-1-PHENETHYLPIPERIDINE Fentanyl Citrate ImpurityⅠ:4-AMINOPHENYL-1-PHENETHYLPIPERIDINE Fentanyl Impurity D Fentanyl Citrate EP Impurity D Stavudine Impurity 5 (Stavudine EP Impurity E) 21409-26-7 Metabolite & Impurities Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Aromatics