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Chelerythrine

Description References
Chelerythrine
Chelerythrine structure
CAS No.
34316-15-9
Chemical Name:
Chelerythrine
Synonyms
Cheleritrine;helerythrine;CHELERYTHRINE;Einecs 251-930-0;Broussonpapyrine;478-03-5 (Hydroxide);3895-92-9 (Chloride);Chelerythrine chlori;Chelerythrine chloride;chelerythrine/toddaline
CBNumber:
CB3506907
Molecular Formula:
C21H18NO4+
Formula Weight:
348.37192
MOL File:
34316-15-9.mol

Chelerythrine Properties

Melting point:
195-205°C
Boiling point:
496.37°C (rough estimate)
Density 
1.2985 (rough estimate)
refractive index 
1.5614 (estimate)
storage temp. 
Desiccate at -20°C
CAS DataBase Reference
34316-15-9(CAS DataBase Reference)
FDA UNII
7IC98TZ0PZ
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xn
Risk Statements  20/21/22
Safety Statements  36/37

Chelerythrine price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C2932 Chelerythrine chloride ≥95% (TLC), powder 34316-15-9 1 mg $56 2021-03-22 Buy
Sigma-Aldrich PHL89896 Chelerythrine chloride phyproof? Reference Substance 34316-15-9 10 mg $116 2021-03-22 Buy
Sigma-Aldrich C2932 Chelerythrine chloride ≥95% (TLC), powder 34316-15-9 5 mg $139 2021-03-22 Buy

Chelerythrine Chemical Properties,Uses,Production

Description

Chelerythrine chloride is the chloride form of Chelerythrine chloride which is a benzophenanthridine alkaloid isolated from the plant Chelidonium majus (greater celandine). It is a kind of potent, selective, and cell-permeable protein kinase C inhibitor, an efficient antagonist of G-protein-coupled CB1 receptors, and an independent activator of MAPK pathways. It has a wide range of biological activities including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. It has reported of that it is capable of inducing apoptosis in HL-60 human promyelocytic leukemia cells and several other cancer cell lines. The underlying mechanism is through its effects of inhibiting the binding of BclXL to Bax or Bad.

References

https://en.wikipedia.org/wiki/Chelerythrine
https://www.scbt.com/scbt/product/chelerythrine-chloride-3895-92-9
https://www.tocris.com/dispprod.php?ItemId=2342#.WQmZVVNsgZQ

Definition

ChEBI: A benzophenanthridine alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae.

Biological Activity

Potent, cell-permeable inhibitor of protein kinase C (IC 50 = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of BclXL to Bak (IC 50 = 1.5 μ M) or Bad proteins and stimulates apoptosis.

Purification Methods

Chelerythrine crystallises from CHCl3 on addition of MeOH [Manske Can J Res 21B 140 1943, UV: Hruban et al. Coll Czech Chem Commun 35 3420 1970]. The pseudo base is colourless while the salts are yellow in aqueous solution and are fluorescent.

Chelerythrine Preparation Products And Raw materials

Raw materials

Preparation Products


Chelerythrine Suppliers

Global( 171)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com CHINA 2712 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
sales@dolonchem.com CHINA 2972 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4000 58
Shaanxi Pioneer Biotech Co., Ltd .
86-13259417953(Whatsapp/Wechat) 86-13259417953(Whatsapp)
029-84385017 sales@pioneerbiotech.com CHINA 3001 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19753 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Shanghai Standard Technology Co., Ltd.
18502101150
+86-21-57127007-6606 ft-sales@nature-standard.com CHINA 1923 58

View Lastest Price from Chelerythrine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-02 chelerythrine
34316-15-9
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2020-05-11 Chelerythrine
34316-15-9
US $0.00 / mg 5mg ≥98%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.
2019-07-06 Chelerythrine chloride
34316-15-9
US $1.00-1.00 / KG 1 mg 99% 100KG career henan chemical co

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