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Docetaxel trihydrate

CAS No.
148408-66-6
Chemical Name:
Docetaxel trihydrate
Synonyms
Xrp6976;Taxespira;Unii-15H5577cqd;DOCETAXEL HYDRATE;Docetaxel (200 mg);Taxotere Trihydrate;Docetaxel (1224551);Docetaxel trihydrate;Docetaxel Tryhydrate;Docetaxel(trihydrous)
CBNumber:
CB3511420
Molecular Formula:
C43H55NO15
Molecular Weight:
825.91
MDL Number:
MOL File:
148408-66-6.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:13

Docetaxel trihydrate Properties

Melting point 186-192°C
storage temp. 2-8°C
solubility Practically insoluble in water, freely soluble in anhydrous ethanol, soluble in methylene chloride.
color White to OFf-White
Stability Hygroscopic
InChIKey XCDIRYDKECHIPE-KHDBCEGQSA-N
CAS DataBase Reference 148408-66-6(CAS DataBase Reference)
FDA UNII 15H5577CQD

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Danger
Hazard statements  H319-H360F
Precautionary statements  P202-P264-P280-P305+P351+P338-P308+P313-P337+P313
WGK Germany  3
HS Code  2932996560

Docetaxel trihydrate price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1883 Docetaxel trihydrate 148408-66-6 200mg $342 2024-03-01 Buy
Sigma-Aldrich 1224551 Docetaxel for system suitability 148408-66-6 200mg $3550 2024-03-01 Buy
Sigma-Aldrich Y0001155 Docetaxel for system suitability European Pharmacopoeia (EP) Reference Standard 148408-66-6 y0001155 $153 2024-03-01 Buy
Sigma-Aldrich Y0001133 Docetaxel trihydrate European Pharmacopoeia (EP) Reference Standard 148408-66-6 y0001133 $220 2024-03-01 Buy
Usbiological 447603 Docetaxel Trihydrate 148408-66-6 5mg $496 2021-12-16 Buy
Product number Packaging Price Buy
PHR1883 200mg $342 Buy
1224551 200mg $3550 Buy
Y0001155 y0001155 $153 Buy
Y0001133 y0001133 $220 Buy
447603 5mg $496 Buy

Docetaxel trihydrate Chemical Properties,Uses,Production

Pharmacology

Docetaxel principally exerts its cytotoxic activity by promoting and stabilising microtubule assembly while simultaneously preventing microtubule depolymerisation. This results in inhibition of normal cell division. In vitro and in vivo, docetaxel has antineoplastic activity against a wide range of cancer cells, demonstrates synergistic activity with several antineoplastic agents and often has greater cytotoxic activity against human breast cancer cell lines than paclitaxel. Docetaxel, binds to and stabilizes tubulin, which prevents physiological microtubule depolymerization/disassembly and results in cell-cycle arrest at the G2/M phase and cell death. This agent also is known to inhibit the anti-apoptotic gene Bcl2 and to encourage the expression of p27, a cell-cycle inhibitor, and further pro-angiogenic factors such as vascular endothelial growth factor (VEGF). Docetaxel is mainly metabolized in the liver by the cytochrome P450 CYP3A4 and CYP3A5 subfamilies of isoenzymes, and its clearance has been shown to be related to body surface area and hepatic enzyme and alpha1 acid glycoprotein plasma levels.

Tolerability

The tolerability of docetaxel in comparative clinical trials was generally acceptable. Severe neutropenia affects most docetaxel recipients, with febrile neutropenia occurring in approximately one-eighth of patients. Dose-cumulative severe fluid retention was reported in docetaxel recipients, despite premedication with prophylactic corticosteroids. Other adverse events include asthenia, stomatitis, infections, neurosensory, cutaneous or gastrointestinal events, nail changes, severe fever in the absence of infection, myalgia and hypersensitivity reactions.

Chemical Properties

White Crystalline Powder

Uses

An antineoplastic. An antimitotic agent that promotes the assembly of microtublules and inhibits their depolymerization to free tubulin

Uses

Docetaxel Trihydrate is an anti-cancer drugs; Semisynthetic analog of the taxane paclitaxel.

Definition

ChEBI: The trihydrate form of docetaxel. It is used for the treatment of breast, ovarian, and non-small cell lung cancer, and with prednisone or prednisolone in hormone-refractory metastatic prostate cancer.

brand name

Taxotere (Sanofi Aventis).

Docetaxel trihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 275)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9354 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Jiangsu Yew Pharmaceutical Co., Ltd.
+86-510-66865338 +86-189-2133-5032 @ junwenjiang@live.cn CHINA 30 60
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Biochempartner
0086-13720134139 candy@biochempartner.com CHINA 967 58
Xiamen AmoyChem Co., Ltd
+86-592-6051114 +8618959220845 sales@amoychem.com China 6387 58
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22968 58
Beijing Yibai Biotechnology Co., Ltd
0086-182-6772-3597 sales04@yibaibiotech.com CHINA 419 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58

Related articles

  • What is Docetaxel trihydrate?
  • Docetaxel (Taxotere?), a cytotoxic taxane, is an antimicrotubule agent effective in the treatment of patients with breast canc....
  • Feb 10,2020

View Lastest Price from Docetaxel trihydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Docetaxel (Trihydrate) pictures 2021-07-13 Docetaxel (Trihydrate)
148408-66-6
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
Docetaxel (Trihydrate) pictures 2021-07-09 Docetaxel (Trihydrate)
148408-66-6
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
Docetaxel trihydrate pictures 2019-07-06 Docetaxel trihydrate
148408-66-6
US $1.00 / KG 1G 98% 100KG Career Henan Chemical Co

Docetaxel trihydrate Spectrum

Docetaxel (200 mg) Taxotere Trihydrate (αR,βS)-β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-benzenepropanoic acid, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester,hydrate (1:3) RP56976 (NSC 628503) Trihydrate Docetaxel(trihydrous) (2AR,4S,4aS,6R,9S,11S,12S,12aS,12bS)-12b-acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2- DOCETAXEL HYDRATE Benzenepropanoic acid, beta-(((1,1-dimethylethoxy)carbonyl)amino)-alpha-hydroxy-, (2ar,4S,4as,6R,9S,11S,12S,12ar,12bs)-12B-(acetyloxy)-12-(benzoyloxy)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-dodecahydro-4,6,11-trihydroxy-4A,8,1313-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-B)oxet-9-yl ester, trihydrate, (alphar,betas)- Unii-15H5577cqd Xrp6976 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv. Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyc Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester trihydrate, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]- Docetaxel trihydrate (αR,βS)-β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-benzenepropanoic acid, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11- Docetaxel/Docetaxel Trihydrate Docetaxel for system suitability CRS Docetaxel trihydrate CRS RP-56976 (Trihydrate) (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-((3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate trihydrate Docetaxel Trihydrate DISCONTINUED PLEASE SEE D494420 Docetaxel Trihydrate (RP 56976) Docetaxel for system suitability (Y0001155) Docetaxel TrihydrateQ: What is Docetaxel Trihydrate Q: What is the CAS Number of Docetaxel Trihydrate Q: What is the storage condition of Docetaxel Trihydrate Q: What are the applications of Docetaxel Trihydrate Docetaxel (1224551) Taxespira (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca3,4benzo1,2-boxet-12-yl benzoate trihydrate Docetaxel Tryhydrate Docetaxel (200 mg) ((2R,3S)-N-Carboxy-3-phenylisoserine, N-tert-butyl ester, 13-ester with 5Beta,20-epoxy-1,2alpha,4,7Beta,10Beta,13alpha-hexahydroxytax-11-en-9-one 4-acetate 2-benzoate trihydrate) 148408-66-6 14848-66-6 C43H59NO17 C43H53NO143H2O C43H59NO7 Anticancer Plant extracts Herb extract TAXOTERE Anti-cancer&immunity Plant extract Inhibitors Intermediates & Fine Chemicals Pharmaceuticals All Inhibitors