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Poly(hexamethylenebiguanide)hydrochloride

CAS No.
32289-58-0
Chemical Name:
Poly(hexamethylenebiguanide)hydrochloride
Synonyms
PHMB;Polihexanide;PHMB(20%);Polihexanide HCl;Polyhexamethylene Biguanidine HCl;BG 1;BG-IR;99%PHMB;PHMB 98;Lavasept
CBNumber:
CB3511879
Molecular Formula:
C10H23N5
Molecular Weight:
213.32312
MDL Number:
MFCD22380012
MOL File:
32289-58-0.mol
MSDS File:
SDS
Last updated:2024-03-16 07:03:48

Poly(hexamethylenebiguanide)hydrochloride Properties

storage temp. Inert atmosphere,Room Temperature
solubility Water
InChI InChI=1S/C10H23N5/c1-9(11)14-7-5-3-4-6-8-15-10(12)13-2/h3-8H2,1-2H3,(H2,11,14)(H3,12,13,15)
InChIKey SAGIGHPRUJPLKX-UHFFFAOYSA-N
SMILES C(=N)(C)NCCCCCCNC(=N)NC
CAS DataBase Reference 32289-58-0(CAS DataBase Reference)
FDA UNII 4XI6112496
ATC code D08AC05
EPA Substance Registry System Poly(iminoimidocarbonyliminoimidocarbonyliminohexamethylene) hydrochloride (32289-58-0)

Poly(hexamethylenebiguanide)hydrochloride price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 089694 Poly (hexamethylene biguanide) hydrochloride 95+% 32289-58-0 25g $115 2021-12-16 Buy
Matrix Scientific 089694 Poly (hexamethylene biguanide) hydrochloride 95+% 32289-58-0 100g $348 2021-12-16 Buy
Ambeed A411573 Poly(hexamethylenebiguanide)hydrochloride 20%inwater 32289-58-0 1kg $121 2021-12-16 Buy
Ambeed A411573 Poly(hexamethylenebiguanide)hydrochloride 20%inwater 32289-58-0 1g $5 2021-12-16 Buy
Ambeed A411573 Poly(hexamethylenebiguanide)hydrochloride 20%inwater 32289-58-0 5g $6 2021-12-16 Buy
Product number Packaging Price Buy
089694 25g $115 Buy
089694 100g $348 Buy
A411573 1kg $121 Buy
A411573 1g $5 Buy
A411573 5g $6 Buy

Poly(hexamethylenebiguanide)hydrochloride Chemical Properties,Uses,Production

Description

PHMB is best known for its broad-spectrum antimicrobial and antifungal activity. It is the standard of care for treatment of Acanthamoeba keratitis and an ingredient in multipurpose contact lens solutions, such as Renu (Bauch & Lomb, Rochester, NY). PHMB is a cationic disinfectant that is effective against Gram-negative and Gram-positive bacteria through its electrostatic interaction with negative sites on the lipopolysaccharide component of bacterial cell membranes. 1.jpg

Application

Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. In dermatological use, it is spelled polihexanide (INN) and sold under names such as Lavasept, Serasept, Prontosan and Omnicide. PHMB has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus (also the methicillin-resistant type, MRSA), Escherichia coli, Candida albicans (yeast), Aspergillus brasiliensis (mold), vancomycin-resistant enterococci, and Klebsiella pneumoniae (carbapenem-resistant enterobacteriaceae).

Safety

On the 20th of April 2018, the european commission decided to ban preservative uses of PHMB PT9 (Fibre, leather, rubber and polymerised materials preservatives). It’s still allowed for uses as disinfectants PT2 (Disinfectants and algaecides not intended for direct application to humans or animals). Furthermore, PHMB has been declared as a candidate for substitution by the ECHA.

Chemical Properties

Colorless to pale yellow solution

Chemical Properties

Poly(hexamethylenebiguanide) hydrochloride is also used as a surface disinfectant and is alleged to be suitable for skin disinfection. This compound has a slow effectand does not meet the practical requirementsfor prophylactic antiseptics in this respect. Although it is somewhat less effective than benzalkonium chloride, it is sometimes used instead of benzalkonium because it is less foamproducing under use conditions.

Uses

Broad spectrum antimicrobial polymer; binds and disrupts cytoplasmic membranes

Preparation

The preparation method of Poly(hexamethylenebiguanide)hydrochloride:By a certain proportion of 1; the own bisguanides of 6-and catalyst join in reaction vessel; under nitrogen protection, said mixture is heated to 80-200 DEGC and reacts, react 2-24 hour; reaction terminates; cooling blowing, obtains poly hexamethylene biguanide, poly hexamethylene biguanide aqueous acid is neutralized to pH value 5-9; and performing filtering so as to obtain a polyhexamethylene biguanidine salt.

Biological Activity

Polyhexamethylene biguanide (PHMB) is a cationic polymer with antimicrobial and antiviral properties. It has been commonly accepted that the antimicrobial activity is due to the ability of PHMB to perforate the bacterial phospholipid membrane leading ultimately to its death.

Properties and Applications

Polyhexamethylene biguanide hydrochloride (PHMB) is a new environment-friendly cationic water-soluble polymer. It is a water solution that can be used as a broad spectrum and high efficient disinfectant. It is low toxic, steady, non-flammable, non-explosive, and basically non-corrosive to stainless steel, copper, carbon steel, wood, and plastic. Because of its special bactericidal mechanisms, almost all kinds of bacteria shall be killed efficiently and will not develop resistance action.

Poly(hexamethylenebiguanide)hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 392)Suppliers
Supplier Tel Email Country ProdList Advantage
WUXI HONOR SHINE CHEMICAL CO.,LTD
0510-83593312 +8613665125081 sales@honorshinechem.com China 61 58
BLiT (Hefei)Chemical Co.,Ltd
sales@blitchem.com China 288 58
Wuhan Boyuan Import & Export Co., LTD
+86-15175982296 15175982296; Mike@whby-chem.com China 983 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2504 58
Shandong Juchuang Chemical Co., LTD
+86-18885615001 +86-18885615001 admin@juchuangchem.com China 387 58
hebei hongtan Biotechnology Co., Ltd
+852-97803454 +86-17731935328 sales01@chemcn.cn China 233 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21703 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9359 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +86-18949832763 info@tnjchem.com China 2989 55
Shanxi Naipu Import and Export Co.,Ltd
+86-13734021967 +8613734021967 kaia@neputrading.com China 1011 58

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  • PHMB is best known for its broad-spectrum antimicrobial and antifungal activity. It is the standard of care for treatment of A....
  • Aug 12,2021

View Lastest Price from Poly(hexamethylenebiguanide)hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Poly(hexamethylenebiguanide)hydrochloride pictures 2024-03-19 Poly(hexamethylenebiguanide)hydrochloride
32289-58-0
US $37650.00-37500.00 / tons 1tons 99% 1000tons Hebei Dangtong Import and export Co LTD
Poly(hexamethylenebiguanide) hydrochloride (PHMB) pictures 2024-03-19 Poly(hexamethylenebiguanide) hydrochloride (PHMB)
32289-58-0
US $0.00 / Kg/Drum 100g ≥99% ≥20% 2000mt Jinan Finer Chemical Co., Ltd
Polyhexamethylene Biguanide pictures 2024-03-16 Polyhexamethylene Biguanide
32289-58-0
US $10.00-7.00 / kg 1kg 99% 1000kg hebei hongtan Biotechnology Co., Ltd
POLY(HEXAMETHYLENEBIGUANIDE) HCL Polyhexamethylene biguanidine Acticide SR 1296 Arlagard E BG 1 BG-IR Cosmocil Lavasept Lonzabac BG 1 Polyhexanide Discontinued Poly-(hexamethylenbiguanid)hydrochlorid polihexanidum Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride poly(hexamethylenebiguanide) hydrochloride Poly(hexamethylene diguanide) hydrochloride PhlyhexaMethylene biguanidine (PHMB) PolyhexaMethylene biguanidine hydrochloride 32289-58-0 PolyhexaMethylene biguanide (PHMB) solution contains 20% PHMB Poly (iMinocarboniMidoyliMinocarboniMidoyliMino-1 PHMB hydrochloride Polyhexamethylene biguanidine hydrochloride, 99%+ Poly six methylene guanidine hydrochloride Polyhexamethyl Biguanide PHMB Polyhexamethylene biguanidine hydrochloride,~20% in water HClPoly(hexamethylenebiguanide)hydrochloride PHMB CAS 32289 58 0 Polihexamide Polihexani Polyhexamethylenbiguanid hydrochloride(PHMB) Phlyhexamethylene biguanidine Polyhexanide Hydrochloride Poly (hexamethylene biguanide) hydrochloride Joyce Polyhexamethylene Biguanidine Hydrochloridr Poly(iminocarbonimidoyliminocarbonimidoylimi PHMB HCl 99% phmb 99%PHMB PHMB 98 discontinuedPoly(hexamethylenebiguanide)hydrochloride Polyhexamethylene Biguanidine Hydrochloride(White Powder) PHMB 98%, 20% solution (Polyhexamethylene biguanide hydrochloride) 20% solution 98% powder Polyhexamethylenbiguanid hydrochloride Polyhexamethylbiguanidine PHMB/ Poly(hexamethylenebiguanide) hydrochloride Polihexanide Polihexanide HCl PHMB(20%) PHMB Polyhexamethylene Biguanidine HCl PHMB/ Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride 1,4-Dioxane 123-91-1 Polyhexamethylene biguanidine hydrochloride 20%solution Polyhexamethylene biguanidine hydrochloride powder Polyhexamethylene biguanidine hydrochloride solution 32289-58-0