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CDK8-IN-1

CDK8-IN-1 structure

CAS No.: 1629633-48-2

Chemical Name:: CDK8-IN-1

Synonyms: CDK8-IN-1;CDK8-IN-16;CDK8IN1,CDK-8-IN-1,CDK8 IN 1;1H-Pyrrole-2-carboxamide, 4-(4-pyridinyl)-3-(trifluoromethyl)-

CBNumber:: CB35540351

Molecular Formula:: C11H8F3N3O

Molecular Weight:: 255.2

MDL Number:

MOL File:: 1629633-48-2.mol

Last updated:2023-05-21 10:59:17

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CDK8-IN-1 Properties

Boiling point	406.2±45.0 °C(Predicted)
Density	1.429±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
pka	12.46±0.50(Predicted)

CDK8-IN-1 Chemical Properties,Uses,Production

Description

CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM.

CDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The tmax is 0.25 h by PO. The mean values of Cmax are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively[1].

References

[1]. Han X, et al. Discovery of potent and selective CDK8 inhibitors through FBDD approach. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4488-4492.

CDK8-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

CDK8-IN-1 Suppliers

Global( 9)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
ShangHai ChuanQian Chemcial Technique Centre	15869524721	3525679403@qq.com	China	3915	58
cjbscvictory	13348960310 13348960310	3003867561@qq.com	China	9946	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24131	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	024-024-88590548 18341751992	757984502@qq.com	China	888	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	4030	58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd	021-59167510 18117107507	vip@med-life.cn	China	5019	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
Aladdin Scientific	58
ShangHai ChuanQian Chemcial Technique Centre	58
cjbscvictory	58
TargetMol Chemicals Inc.	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
Nantong QuanYi Biotechnology Co., Ltd	58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd	58

CDK8-IN-1 CDK8-IN-16 CDK8IN1,CDK-8-IN-1,CDK8 IN 1 1H-Pyrrole-2-carboxamide, 4-(4-pyridinyl)-3-(trifluoromethyl)- 1629633-48-2