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1-Bromo-3,5-difluorobenzene

1-Bromo-3,5-difluorobenzene Structure
1-Bromo-3,5-difluorobenzene structure
CAS No.
461-96-1
Chemical Name:
1-Bromo-3,5-difluorobenzene
Synonyms
3,5-DIFLUOROBROMOBENZENE;DM1Impurity22;uorobromobenzene;5-difluorobenzene;1-Bromo-3,5-difluoro;1-Brom-3,5-difluorbenzol;3,5-difluoro-1-bromobenzene;1-BROMO-3,5-DIFLUOROBENZENE;1-Bromo-3,5-difulorobenzene;1,3-Difluoro-5-bromobenzene
CBNumber:
CB3668317
Molecular Formula:
C6H3BrF2
Molecular Weight:
192.99
MDL Number:
MFCD00010305
MOL File:
461-96-1.mol
MSDS File:
SDS
Last updated:2025-09-25 17:15:13
Product description Number Pack Size Price
1-Bromo-3,5-difluorobenzene 98% 290165 10g $58.66
1-Bromo-3,5-difluorobenzene 98% 290165 100g $198.59
1-Bromo-3,5-difluorobenzene >98.0%(GC) B1764 25g $60
1-Bromo-3,5-difluorobenzene >98.0%(GC) B1764 250g $241
1-Bromo-3,5-difluorobenzene 158405 25g $403
More product size
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1-Bromo-3,5-difluorobenzene Properties

Melting point -27 °C
Boiling point 140 °C (lit.)
Density 1.676 g/mL at 25 °C (lit.)
refractive index n20/D 1.499(lit.)
Flash point 112 °F
storage temp. Sealed in dry,2-8°C
solubility 0.238g/l
form Liquid
Specific Gravity 1.686
color Clear colorless to light yellow
PH 6.6 (0.238g/l, H2O, 20℃)
Water Solubility 0.238 g/L (20 ºC)
BRN 1931520
InChIKey JHLKSIOJYMGSMB-UHFFFAOYSA-N
CAS DataBase Reference 461-96-1(CAS DataBase Reference)
EWG's Food Scores 1-3
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07,GHS08,GHS09
Signal word  Warning
Hazard statements  H226-H302-H315-H317-H373-H410
Precautionary statements  P210-P273-P280-P301+P312-P303+P361+P353-P314
Hazard Codes  Xn,N,F,Xi
Risk Statements  10-22-38-43-48/22-50/53-36/37/38
Safety Statements  24-36/37-60-61-36-26-16
RIDADR  UN 1993 3/PG 3
WGK Germany  2
Hazard Note  Flammable
HazardClass  3
PackingGroup  III
HS Code  29039990
Limited Quantities 5.0 L (1.3 gallons) (liquid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
2
2 0

1-Bromo-3,5-difluorobenzene price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 290165 1-Bromo-3,5-difluorobenzene 98% 461-96-1 10g $58.66 2025-07-31 Buy
Sigma-Aldrich 290165 1-Bromo-3,5-difluorobenzene 98% 461-96-1 100g $198.59 2025-07-31 Buy
TCI Chemical B1764 1-Bromo-3,5-difluorobenzene >98.0%(GC) 461-96-1 25g $60 2025-07-31 Buy
TCI Chemical B1764 1-Bromo-3,5-difluorobenzene >98.0%(GC) 461-96-1 250g $241 2025-07-31 Buy
Usbiological 158405 1-Bromo-3,5-difluorobenzene 461-96-1 25g $403 2021-12-16 Buy
Product number Packaging Price Buy
290165 10g $58.66 Buy
290165 100g $198.59 Buy
B1764 25g $60 Buy
B1764 250g $241 Buy
158405 25g $403 Buy

1-Bromo-3,5-difluorobenzene Chemical Properties,Uses,Production

Chemical Properties

CLEAR COLOURLESS TO LIGHT YELLOW LIQUID

Uses

1-Bromo-3,5-difluorobenzene was used in the synthesis of 4-bromo-2,6-difluorobenzoic acid.

Uses

Intermediates of Liquid Crystals

Synthesis Reference(s)

Journal of Medicinal Chemistry, 30, p. 486, 1987 DOI: 10.1021/jm00386a008

Synthesis

Hypophosphorous acid

6303-21-5

2-BROMO-4,6-DIFLUOROANILINE HYDROBROMIDE

101471-20-9

1-Bromo-3,5-difluorobenzene

461-96-1

General procedure: A diazonium salt solution was prepared by dissolving 1 mole of 2-bromo-4,6-difluoroaniline hydrobromide in aqueous HCl with 1.1-1.10 moles of NaNO2 at 0°C to 5°C. The solution was then slowly warmed to 15°C, during which time the release of nitrogen was observed. To this solution, 1.5 moles of hypophosphorous acid was added at a temperature below 5°C, followed by a slow warming to 15°C, during which the release of nitrogen was observed. The reaction mixture is stirred for 1 hour, decanted and extracted with a suitable organic solvent to give 1-bromo-3,5-difluorobenzene in 75% molar yield. The target product with purity higher than 99% was obtained by distillation. This method is also applicable to the synthesis of other 1-bromo-3,5-dihalobenzenes.

References

[1] Patent: US5157169, 1992, A

1-Bromo-3,5-difluorobenzene Preparation Products And Raw materials

Raw materials

Hydrochloric acid Bromine Hypophosphorous acid 2-BROMO-4,6-DIFLUOROANILINE HYDROBROMIDE Sodium nitrite

Preparation Products

2,6-Difluoro-4-hydroxybenzonitrile 3,5-DIFLUORO-BENZAMIDINE HYDROCHLORIDE 3,5-Difluorobenzoic acid 1-ETHYNYL-3 5-DIFLUOROBENZENE 97 4-BROMO-2,6-DIFLUOROBENZYL ALCOHOL
4-Bromo-2,6-difluoroiodobenzene 6-BROMO-4-FLUORO-1H-INDAZOLE (3 5-DIFLUOROPHENYLETHYNYL)TRIMETHYLSIL& 9,9'-(5-bromo-1,3-phenylene)bis(9H-carbazole)

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1-Bromo-3,5-difluorobenzene Suppliers

Global( 564)Suppliers
Supplier Tel Email Country ProdList Advantage
Qi-Chem Co., Ltd.
+86-15633578820 +86-13591335396 chris.wang@qi-chem.com China 133 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8770 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5250 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20171 58
airuikechemical co., ltd. 		+86-18353166132 sales02@airuikechemical.com China 983 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13505 58
Hi-Tech Chemistry Corp 		0519-86626038 yuhh@hitechem.com CHINA 810 58
Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1803 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3009 60
Supplier Advantage
Qi-Chem Co., Ltd.
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Henan Fengda Chemical Co., Ltd 		58
airuikechemical co., ltd. 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Hi-Tech Chemistry Corp 		58
Shanghai Time Chemicals CO., Ltd. 		55
Nanjing ChemLin Chemical Industry Co., Ltd. 		60

View Lastest Price from 1-Bromo-3,5-difluorobenzene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-Bromo-3,5-difluorobenzene pictures 2025-11-10 1-Bromo-3,5-difluorobenzene
461-96-1
 US $0.00-0.00 / KG 1KG 99% 20 mt Hebei Chuanghai Biotechnology Co., Ltd
1-Bromo-3,5-difluorobenzene pictures 2025-09-25 1-Bromo-3,5-difluorobenzene
461-96-1
 US $100.00-1.00 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
1-Bromo-3,5-difluorobenzene pictures 2025-08-08 1-Bromo-3,5-difluorobenzene
461-96-1
 US $10.00 / Kg/Bag 25KG 99.99% 200ton Sichuan Zhuoyu Yantang Technology Co., Ltd.

1-Bromo-3,5-difluorobenzene Spectrum

1-Bromo-3,5-difluorobenzene(461-96-1)MS1-Bromo-3,5-difluorobenzene(461-96-1)1HNMR1-Bromo-3,5-difluorobenzene(461-96-1)13CNMR1-Bromo-3,5-difluorobenzene(461-96-1)IR1

461-96-1(1-Bromo-3,5-difluorobenzene)Related Search:

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Florfenicol 4-Bromofluorobenzene 1-Bromo-3,5-dichlorobenzene 1,2-Dibromotetrafluorobenzene 1,4-DIBROMOTETRAFLUOROBENZENE
2-BROMO-4,5,6-TRIFLUOROANILINE Bromopentafluorobenzene Bromine 1-BROMO-2,3,5,6-TETRAFLUOROBENZENE 1-Bromo-2,3,5-trifluorobenzene
2-Bromo-4,6-difluoroaniline 1,2-DIBROMO-3,5-DIFLUOROBENZENE 4,4'-DIBROMOOCTAFLUOROBIPHENYL

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1-Bromo-3,5-difluorobenzene,99% 1-BROMO-3,5-DIFLUOROBENZENE 1-Bromo-3,5-difluorobenzene,98% [3,5-Difluorobromobenzene] 3,5-difluoro-1-bromobenzene 1-Bromo-3,5-difluorobenzene 98% 1-Bromo-3,5-difluorobenzene98% 1-Brom-3,5-difluorbenzol 3,5-DIFLUOROBROMOBENZENE A.K.A.1-BROMO-3,5-DIFLUOR 3,5-DIFLUORO BROMO BENZENE 461-96-1 1-BroMo-35-difluorobenzene/35-Difluorochlorobenzene 3,5-DifluorobroMobenzene, 97+% 3, 5 - two fluorine broMobenzene 1-Bromo-3,5-difluoro 3,5-Difluorobromobenzene 98% 5-difluorobenzene 1-BroMo-3,5-difluorobenzene, 99% 10ML 1-Bromo-3,5-difulorobenzene 1,3-Difluoro-5-bromobenzene 1-Bromo-3,5-difluorobenzene > uorobromobenzene Benzene, 1-bromo-3,5-difluoro- 1-Bromo-3,5-difluorobenzene ISO 9001：2015 REACH 3,5-DIFLUOROBROMOBENZENE DM1Impurity22 1-Bromo-3,5-difluorobenzene, 98%min 461-96-1 C6H3BrF2 Building Blocks Aryl Halogenated Hydrocarbons Organic Building Blocks HALIDE C6 Aromatic Hydrocarbons (substituted) & Derivatives Halogenated Hydrocarbons Aryl Miscellaneous Fluorobenzene Fluorine series bc0001 C6