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BISNORCHOLENALDEHYDE

BISNORCHOLENALDEHYDE structure

CAS No.: 3986-89-8

Chemical Name:: BISNORCHOLENALDEHYDE

Synonyms: BNKY018-PG01;Bisnorcholeldehyde;KETOBISNORALDEHYDE;Bisnorcholenaldehyde;Progesterone Impurity 7;Progesterone Impurity 24;Progesterone EP Impurity I;Didroprogesterone impurity 2;Progesterone EP Impurity I-02;(20S)-20-Formylpregn-4-en-3-one

CBNumber:: CB3670455

Molecular Formula:: C22H32O2

Molecular Weight:: 328.49

MDL Number:: MFCD00056488

MOL File:: Mol file

MSDS File:: SDS

Last updated:2025-01-06 13:21:43

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BISNORCHOLENALDEHYDE Properties

Melting point	159-160 °C
Boiling point	459.4±14.0 °C(Predicted)
Density	1.07±0.1 g/cm3(Predicted)
solubility	Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly)
form	Solid
color	White to Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H351-H362-H360
Precautionary statements	P201-P202-P281-P308+P313-P405-P501-P201-P260-P263-P264-P270-P308+P313

BISNORCHOLENALDEHYDE Chemical Properties,Uses,Production

Description

Androstenedione is the main product after phytosterol fermentation by Mycobacteria. Bisnorcholenaldehyde (BA; 3-Oxopregn-4-ene-20-carboxaldehyde) is one of the by-products produced during fermentation. Bisnorcholenaldehyde is an essential intermediate in the production of progesterone, which is used to treat threatened abortion or habitual abortion disease caused by luteal insufficiency. It is a precursor of androgen, estrogen, glucocorticoid and intermediates of steroid hormone synthesis[1]. In addition, BA is used in magnetic-based graphene composites with steroidal diamine dimer as a potential drug in hyperthermia cancer therapy.

Uses

Bisnorcholenaldehyde is hydrocarbon derivatives and can be used as reference materials for medical impurities.

Toxics Screening Level

The initial threshold screening level (ITSL) for progesterone 4 is 0.04 μg/m3 based on an annual averaging time.

References

[1] Shi-Dong Xu. “Refining androstenedione and bisnorcholenaldehyde from mother liquor of phytosterol fermentation using macroporous resin column chromatography followed by crystallization.” Journal of Chromatography B 1079 (2018): Pages 9-14.

BISNORCHOLENALDEHYDE synthesis

Synthesis of BISNORCHOLENALDEHYDE from 3-keto-23,24-bisnorchol-4-en-22-ol

BISNORCHOLENALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

21-hydroxy-20-methylpregn-4-en-3-one

BISNORCHOLENALDEHYDE Suppliers

Global( 37)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BIONNA MEDICINE CO.,LTD	01056380788-8515; +8618518759099	790226113@qq.com	China	52	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Shenzhen Excellent Biomedical Technology Co.,Ltd.	+undefined18318671572	sale@ex-biotech.com	China	1092	58
China National Standard Pharmaceutical Corporation Limited	+8615391658522	overseasales@yongstandards.com	China	11922	58
Guangzhou CATO Research Chemicals Inc.	+86-020-81960175-617 +8615602392859	Intermediate@cato-chem.com	China	6335	58
Moxin Chemicals	+8617320513646	Anna@molcoo.com	China	10586	58
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.	+8618950047208	ellena@amitychem.com	China	43416	58
J & K SCIENTIFIC LTD.	18210857532	jkinfo@jkchemical.com	China	96815	76
ChemStrong Scientific Co.,Ltd	0755-0755-66853366 13670046396	sales@chem-strong.com	China	18146	56
Shanghai Kewel Chemical Co., Ltd.	021-64609169 18901607656	greensnown@163.com	China	9906	50

Supplier	Advantage
BIONNA MEDICINE CO.,LTD	58
Standardpharm Co. Ltd.	58
Shenzhen Excellent Biomedical Technology Co.,Ltd.	58
China National Standard Pharmaceutical Corporation Limited	58
Guangzhou CATO Research Chemicals Inc.	58
Moxin Chemicals	58
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.	58
J & K SCIENTIFIC LTD.	76
ChemStrong Scientific Co.,Ltd	56
Shanghai Kewel Chemical Co., Ltd.	50

BISNORCHOLENALDEHYDE Spectrum

BISNORCHOLENALDEHYDE(3986-89-8)MS BISNORCHOLENALDEHYDE(3986-89-8)¹HNMR BISNORCHOLENALDEHYDE(3986-89-8)¹³CNMR

3986-89-8(BISNORCHOLENALDEHYDE)Related Search:

20α-Acetoxy-4-pregnen-3-one (17α)-Pregn-4-ene-3,20-dione 4-PREGNEN-20-ALPHA-OL-3-ONE 4,9(11)-PREGNADIEN-3,20-DIONE 4-PREGNEN-20-BETA-OL-3-ONE

1,4-PREGNADIEN-3,20-DIONE Progesterone EP Impurity G Progesterone EP Impurity F Benzene, 2-[[2-[(6-broMohexyl)oxy]ethoxy]Methyl]-1,3-dichloro 21ξ-morpholino-23,24-dinor-chola-4,20-dien-3-one

Androstenone hydrazone 17-Iodoandrosta-5,16-dien-3beta-ol tert-Butyl (2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-oxoethyl)carbamate CarbaMic acid, [(2R)-2-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]-, 1,1-diMethylethyl ester 2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)-

N-(1-Cyclohexen-1-yl)morpholine Abiraterone Pregna-4,6-diene-3,20-dione

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KETOBISNORALDEHYDE 3-KETO-4-PREGNENE-20-BETA-CARBOXALDEHYDE 4-PREGNEN-20BETA-CARBOXALDEHYDE-3-ONE 4-PREGNEN-3-ONE-20-BETA-CARBOXALDEHYDE Progesterone EP Impurity I Progesterone Impurity 7 Progesterone EP Impurity I (S-isomer) (20S)-3-oxopregn-4-ene-20-carboxaldehyde BNKY018-PG01 Bisnorcholeldehyde Pregn-4-ene-20-carboxaldehyde, 3-oxo-, (20S)- (S)-2-((8S,9S,10R,13S,14S,17R)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)propanal 3-Oxo-pregn-4-ene-20α- carboxaldehyde Progesterone Impurity 24 (20S)-20-Formylpregn-4-en-3-one (S)-2-((8S,9S,10R,13S,14S,17R)-10,13-Dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)propanal (Progesterone Impurity) Bisnorcholenaldehyde Progesterone EP Impurity I-02 Progesterone Impurity(S-Isomer) Didroprogesterone impurity 2 (2S)-2-[(8S,9S,10R,13S,14S,17R)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]propanal (2S)-2-[(8S,9S,10R,13R,14S,17R)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]propanal 3986-89-8