Phenylacetone
- CAS No.
- 103-79-7
- Chemical Name:
- Phenylacetone
- Synonyms
- BENZYL METHYL KETONE;1-PHENYL-2-PROPANONE;1-PHENYLACETONE;Phenylaceton;PHENYL-2-PROPANONE;1-Phenyl-2-acetone;Methyl benzyl ketone;1-phenyl-propan-2-one;2-Propanone, 1-phenyl-;PHENYLACETONE
- CBNumber:
- CB3671179
- Molecular Formula:
- C9H10O
- Molecular Weight:
- 134.18
- MDL Number:
- MFCD00017249
- MOL File:
- 103-79-7.mol
| Product description | Number | Pack Size | Price |
| Dextroamphetamine Related Compound B certified reference material, pharmaceutical secondary standard | PHR8965 | 1 unit | $600 |
| Phenylacetone (exempt preparation) | 16444 | 1mg | $60 |
| Phenylacetone | 16103 | 100mg | $106 |
| Phenylacetone | 16103 | 10mg | $31 |
| Phenylacetone | 16103 | 50mg | $68 |
| Melting point | -15 °C |
|---|---|
| Boiling point | 216 °C |
| Density | 1.003 g/mL at 20 °C(lit.) |
| refractive index | 1.5155-1.5175 |
| Flash point | 83°C |
| storage temp. | Controlled Substance, -20°C Freezer |
| solubility | DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Methanol: 50 mg/ml |
| Water Solubility | Insoluble |
| BRN | 742120 |
| Major Application | pharmaceutical |
| InChI | 1S/C9H10O/c1-8(10)7-9-5-3-2-4-6-9/h2-6H,7H2,1H3 |
| InChIKey | QCCDLTOVEPVEJK-UHFFFAOYSA-N |
| SMILES | CC(=O)Cc1ccccc1 |
| LogP | 1.440 |
| CAS DataBase Reference | 103-79-7(CAS DataBase Reference) |
| EWG's Food Scores | 1-3 |
| FDA UNII | O7IZH10V9Y |
| NIST Chemistry Reference | Benzyl methyl ketone(103-79-7) |
| EPA Substance Registry System | 2-Propanone, 1-phenyl- (103-79-7) |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UC3500100 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29143910 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 | |||||||||
| Hazardous Substances Data | 103-79-7(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 intraperitoneal in mouse: 540mg/kg | |||||||||
| DEA Controlled Substances | CSCN: 8501 CSA SCH: Schedule II NARC: No |
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| NFPA 704 |
|
Phenylacetone Chemical Properties,Uses,Production
Description
Phenylacetone (exempt preparation) (Item No. 16444) is an analytical reference standard categorized as a precursor in the synthesis of amphetamine and methamphetamine. Phenylacetone is regulated as a Schedule II compound in the United States. Phenylacetone (exempt preparation) (Item No. 16444) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.
Chemical Properties
1-Phenyl-2-propanone is a colorless liquid with a pleasant odor; it is insoluble in water and soluble in organic solvents.
Uses
A metabolite of Lisdexamfetamine dimesylate. 1-Phenyl-2-propanone is used as an intermediate for the synthesis of pharmaceuticals, e.g., Prenylamine, a coronary vasodilator (Hoechst) .
Uses
In organic synthesis; production of benzyl radicals by photolysis.
Definition
ChEBI: Phenylacetone is a propanone that is propan-2-one substituted by a phenyl group at position 1. It is a member of propanones and a methyl ketone.
Production Methods
1-Phenyl-2-propanone is produced by catalytic ketonization of phenylacetic acid with acetic acid over an alumina-supported cerium oxide catalyst at 400 – 500℃. It may also be produced by the rearrangement of phenylpropylene oxide on zeolites or oxidation of 2-phenylpropanol.
References
[1] W KRAWCZYK. Impurity profiling/comparative analyses of samples of 1-phenyl-2-propanone.[J]. Bulletin on narcotics, 2005, 57 1-2: 33-62.
[2] A SINNEMA A M V. Impurities in illicit amphetamine: review.[J]. Bulletin on narcotics, 1981, 33 3: 37-54.
Phenylacetone Preparation Products And Raw materials
Raw materials
Preparation Products
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