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Neostigmine bromide

Neostigmine bromide
Neostigmine bromide structure
CAS No.
114-80-7
Chemical Name:
Neostigmine bromide
Synonyms
Prostigmi;Neoesserin;Neostigmin;prostigmin;Juvastigmin;PROSTIGMINE;stigmosanbromide;stigmanolbromide;eustigminbromide;neoserinebromide
CBNumber:
CB3677212
Molecular Formula:
C12H19BrN2O2
Formula Weight:
303.2
MOL File:
114-80-7.mol

Neostigmine bromide Properties

Melting point:
175-177 °C(lit.)
Density 
1.4344 (rough estimate)
refractive index 
1.5410 (estimate)
storage temp. 
-20?C Freezer
solubility 
H2O: 1 g/mL
form 
powder
color 
white
PH
5.2~6.2 (100g/l, 25℃)
Water Solubility 
1 g/ mL
Merck 
14,6464
EPA Substance Registry System
Benzenaminium, 3-[[(dimethylamino)carbonyl] oxy]-N,N,N-trimethyl-, bromide(114-80-7)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T+,T
Risk Statements  26/27/28-36/37/38-42/43-25
Safety Statements  22-26-36/37/39-45-37/39-28A
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  BR3150000
HazardClass  6.1(a)
PackingGroup  II
HS Code  29239000
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger P264, P270, P301+P310, P321, P330,P405, P501
H310 Fatal in contact with skin Acute toxicity,dermal Category 1, 2 Danger P262, P264, P270, P280, P302+P350,P310, P322, P361, P363, P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H330 Fatal if inhaled Acute toxicity,inhalation Category 1, 2 Danger P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger P261, P285, P304+P341, P342+P311,P501
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P320 Specific treatment is urgent (see … on this label).
P330 Rinse mouth.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P350 IF ON SKIN: Gently wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Neostigmine bromide price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N2001 Neostigmine bromide ≥98% (HPLC and titration), powder 114-80-7 1g $90.1 2018-11-13 Buy
Sigma-Aldrich 1459001 Neostigmine bromide United States Pharmacopeia (USP) Reference Standard 114-80-7 200mg $348 2018-11-13 Buy
TCI Chemical N0358 Neostigmine Bromide >99.0%(T) 114-80-7 5g $88 2018-11-22 Buy
TCI Chemical N0358 Neostigmine Bromide >99.0%(T) 114-80-7 25g $256 2018-11-22 Buy
Alfa Aesar J62300 Neostigmine bromide 114-80-7 250mg $43.6 2018-11-13 Buy

Neostigmine bromide Chemical Properties,Uses,Production

Chemical Properties

Crystalline Solid

Uses

antiscorbutic, antiviral

Uses

Cholinergic; miotic; antidote (curare)

General Description

Neostigmine bromide, (m-hydroxyphenyl)trimethylammonium bromide dimethylcarbamateor the dimethylcarbamic ester of 3-hydroxyphenyltrimethylammoniumbromide (Prostigmin bromide), is usedas an antidote to nondepolarizing neuromuscular blockingdrugs and in the treatment of myasthenia gravis. It occurs asa bitter, odorless, white, crystalline powder. It is soluble inwater and alcohol. The crystals are much less hygroscopicthan those of neostigmine methylsulfate and thus may beused in tablets. Solutions are stable and may be sterilized byboiling. Aqueous solutions are neutral to litmus.

Clinical Use

Use of physostigmine, as a prototype of an indirect-actingparasympathomimetic drug, facilitated the development ofstigmine, in which a trimethylamine group was placed para toa dimethylcarbamate group in benzene. Better inhibition ofcholinesterase was observed when these groups were placedmeta to each other as in neostigmine, a more active and usefulagent. Although physostigmine contains a methylcarbamatefunctional group, greater chemical stability towardhydrolysis was obtained with the dimethylcarbamyl group inneostigmine.

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of Br-, NH3, and NOx. See also CARBAMATES and BROMIDES.

Purification Methods

Crystallise neostigmine bromide from EtOH/diethyl ether. Its solubility in H2O is ~50%. [Beilstein 13 III 939.] (It is cholinergic and highly TOXIC.) The starting material 3-dimethylcarbamoyl-N,N-dimethylaniline [59-99-4] has b 195o/20mm [Beilstein 13 III 936], and its picrate has m 138o (from EtOH).

Neostigmine bromide Preparation Products And Raw materials

Raw materials

Preparation Products


Neostigmine bromide Suppliers

Global( 113)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20580 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23982 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40277 62
TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
021-67121385 Sales-CN@TCIchemicals.com China 24560 81
Energy Chemical 021-58432009 / 400-005-6266
021-58436166-800 info@energy-chemical.com China 44046 61
Adamas Reagent, Ltd. 400-600-9262
bxy@titansci.com China 13922 59
Chemfun Medical Technology(Shanghai) Co., Ltd. 021-67220633 & 021-37212706
+86-21-67220638 chemfun@chemfun.net China 21815 59

View Lastest Price from Neostigmine bromide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-23 Neostigmine bromide
114-80-7
US $2.00 / kg 1kg 99% 100kg career henan chemical co

Neostigmine bromide Spectrum


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