PYRILAMINE MALEATE

PYRILAMINE MALEATE Properties

Melting point	101-103°C
storage temp.	2-8°C
solubility	Very soluble in water, freely soluble in ethanol (96 per cent).
color	White
Water Solubility	Soluble in water at 100mg/ml
λmax	310nm(EtOH)(lit.)
Merck	14,7984
Stability	Stability Combustible. Incompatible with strong oxidizing agents.
LogP	2.751 (est)
FDA 21 CFR	310.545; 341.12
CAS DataBase Reference	59-33-6(CAS DataBase Reference)
FDA UNII	R35D29L3ZA
EPA Substance Registry System	Pyrilamine maleate (59-33-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P264-P270-P301+P312-P302+P352-P305+P351+P338

Hazard Codes

Xn

Risk Statements

22-36/37/38

Safety Statements

26-36/37

WGK Germany

3

RTECS

UT1225000

TSCA

Yes

HS Code

2933399090

Toxicity

LD50 orally in mice: 338 mg/kg (Hunziker)

NFPA 704

	0
2		0

PYRILAMINE MALEATE price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	P5514	Pyrilamine maleate salt	59-33-6	5g	$74.1	2024-03-01	Buy
Sigma-Aldrich	1588004	Pyrilamine maleate United States Pharmacopeia (USP) Reference Standard	59-33-6	200mg	$360	2024-03-01	Buy
TCI Chemical	P2369	Pyrilamine Maleate >98.0%(HPLC)(T)	59-33-6	5g	$39	2024-03-01	Buy
TCI Chemical	P2369	Pyrilamine Maleate >98.0%(HPLC)(T)	59-33-6	25g	$113	2024-03-01	Buy
Alfa Aesar	J63247	Pyrilamine maleate	59-33-6	25g	$124.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
P5514	5g	$74.1	Buy
1588004	200mg	$360	Buy
P2369	5g	$39	Buy
P2369	25g	$113	Buy
J63247	25g	$124.65	Buy

PYRILAMINE MALEATE Chemical Properties,Uses,Production

Description

Mepyramine is a first generation antihistamine that acts as an inverse agonist at the histamine H₁ receptor. It is reported to bind with high affinity to a G_q/11 protein-coupled form of the receptor and to promote a G protein-coupled inactive state of the H₁ receptor that interferes with the G_q/11-mediated signaling of the endogenously expressed receptor, as well as to reduce G protein availability for other non-related receptors associated with this signaling pathway. Mepyramine has been shown to inhibit histamine-induced inositol phosphate production with a log EC₅₀ value of -7.94.

Chemical Properties

solid

Uses

Pyrilamine maleate Selective inverse agonist for the H-1 histamine receptor. Pyrilamine Maleate is commonly utilized as a radioligand ([3H]Mepyramine) binding assay for the H1 receptor. And also used to exhibit blocking ability of KCNQ/M channels which is potentially related to an adverse effect seen in excess intake of antihistamines.

Uses

A histamine H1 receptor antagonist

Uses

Mepyramine maleate is used as bulk pharmaceutical (antihistaminic). Product Data Sheet

brand name

Histavet-P [Veterinary] (Schering-Plough Animal Health); Pymafed (HoechstRoussel).

General Description

Pyrilamine, 2-[4-methoxybenzyl[2-dimethylamino)ethyl]-amino]pyridine, is available as theacid maleate salt (1:1), which is a white crystalline powderwith a faint odor and a bitter, saline taste. The salt is solublein water (1:0.4) and freely soluble in alcohol. A 10% solutionhas a pH of approximately 5. At a pH of 7.5 or above,the free base begins to precipitate.
Pyrilamine differs structurally from tripelennamine byhaving a methoxy group in the para position of the benzylradical. It differs from its more toxic and less potent precursorphenbenzamine (Antergan) by having a 2-pyridyl groupon the nitrogen atom in place of a phenyl group.
Clinically, pyrilamine and tripelennamine are consideredamong the less potent antihistaminics. They are highly potent,however, in antagonizing histamine-induced contractionsof guinea pig ileum. Because of the pronounced localanesthetic action, the drug should not be chewed, but takenwith food.

General Description

White crystals or powder. Melting point 100-101°C. Bitter saline taste. An antihistaminic medicine.

Air & Water Reactions

Water soluble.

Reactivity Profile

PYRILAMINE MALEATE is an acidic salt of an amine. Usually does not react as either oxidizing agents or reducing agents but such behavior is not impossible. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

SYMPTOMS: Symptoms of exposure to PYRILAMINE MALEATE may include drowsiness, potentiation of the sedative effect of barbituates, fatigues, vertigo, incoordination, tremor, muscle weakness, dryness of the mouth and throat, tinnitus, pupillary dilation, blurred vision, urinary retention, impotence, epigastric and intestinal pain, anorexia, nausea, vomiting, diarrhea, excitation, euphoria, insomnia, nervousness, palpitation, tachycardia, hypotension, hypersensitivity reactions, respiratory depression, coma and delirium.

Fire Hazard

Flash point data for PYRILAMINE MALEATE are not available, however PYRILAMINE MALEATE is probably combustible.

Biological Activity

Selective inverse agonist for the H 1 receptor. Inhibits histamine induced inositol phosphate (InsP) production (log EC50 = -7.94) and intracellular calcium mobilization. Sequesters G q/11 protein, reducing its availability for other receptors associated with the same signaling pathway.

Biochem/physiol Actions

Pyrilamine maleate is a H1 histamine receptor antagonist. Pyrilamine maleate induces sleep in vertebrates. In Cassiopea, it induces concentration dependent dormancy.

Safety Profile

A human poison by ingestion. An experimental poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. An antihistamine. When heated to decomposition it emits toxic fumes of NOx.

Veterinary Drugs and Treatments

Antihistamines are used in veterinary medicine to reduce or help prevent histamine mediated adverse effects; predominantly used in horses.

storage

Room temperature

PYRILAMINE MALEATE Preparation Products And Raw materials

Raw materials

Preparation Products

PYRILAMINE MALEATE Suppliers

Global( 197)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569265 +86-18612256290	1056@dideu.com	China	3683	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9409	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29322	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
Henan Alfa Chemical Co., Ltd	+8618339805032	alfa4@alfachem.cn	China	12755	58

Supplier	Advantage
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
TargetMol Chemicals Inc.	58
Shaanxi Dideu Medichem Co. Ltd	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Henan Alfa Chemical Co., Ltd	58

View Lastest Price from PYRILAMINE MALEATE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-07-20	PyrilaMine Maleate Salt 59-33-6	US $1.00-1.00 / KG	1g	99%	50tons	Shaanxi Dideu Medichem Co. Ltd
2021-06-17	PYRILAMINE MALEATE USP/EP/BP 59-33-6	US $1.10 / g	1g	99.9%	100 Tons Min	Dideu Industries Group Limited
2019-07-12	PYRILAMINE MALEATE 59-33-6	US $1.00 / KG	1KG	99%	25kg	Career Henan Chemical Co

PyrilaMine Maleate Salt
59-33-6
US $1.00-1.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

PYRILAMINE MALEATE USP/EP/BP
59-33-6
US $1.10 / g
99.9%
Dideu Industries Group Limited

PYRILAMINE MALEATE
59-33-6
US $1.00 / KG
99%
Career Henan Chemical Co

PYRILAMINE MALEATE Spectrum

PYRILAMINE MALEATE(59-33-6)¹HNMR

59-33-6(PYRILAMINE MALEATE)Related Search:

FORMANILIDE 4-Aminodiphenylamine 2-Benzylaminopyridine 2-(4-Methoxybenzylamino)pyridine PYRILAMINE

2-DIETHYLAMINOPYRIDINE Tripelennamine N,N'-Dimethyl-1,2-ethanediamine (METHOXYMETHYL)DIPHENYLPHOSPHINE OXIDE N,N-Dimethylethylenediamine

PYRILAMINE MALEATE Ammonium hydrogen maleate N-METHYL-N-PYRIDIN-2-YLETHANE-1,2-DIAMINE N-2-Pyridinyl-1,2-ethanediamine N'-(5-AMINOPENTYL)-N-(4-METHOXYBENZYL)-N'-METHYL-N-2-PYRIDINYL-1,2-ETHANEDIAMINE, DIMALEATE SALT

2-(ETHYLMETHYLAMINO)PYRIDINE N-(4-Methoxybenzyl)-N-2-pyridinyl-1,2-ethanediamine [[(2-aminoethyl)amino]methyl]phenol

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MEPYRAMINE MALEATE MEPYRAMINE MALEATE SALT n-dimethylaminoethyl-n-p-methoxy-alpha-aminopyridinemaleate neo-anterganmeleate n-p-methoxybenzyl-n’-n’-dimethyl-n-alpha-pyridylethylenediaminemaleate paramal paraminylmaleate pymafed pyramaleate pyranilaminemaleate pyraninyl pyrilaminemaleatecrystalline renstamin stangenmaleate statominmaleate thylogenmaleate PYRILAMINE MALEATE METHANOL SOLUTION 2-((2-Dimethylaminoethyl)-(p-methoxybenzyl)amino)p(mepyraminemaleate) 2-[(2-DIMETHYLAMINOETHYL)(P-METHOXYBENZYL)AMINO]PYRIDINE MALEATE PYRILAMINE MALEATE PYRILAMINE MALEATE SALT PYRANISAMINE MALEATE N-(P-METHOXYBENZYL)-N',N'-DIMETHYL-N-2-PYRIDYLETHYLENEDIAMINE MALEATE N-[4-METHOXY-PHENYL]METHYL-N',N'-DIMETHYL-N[2-PYRIDINYL]-1,2-ETHANEDIAMINE MALEATE SALT antihist diaminidemaleate minihist n-((4-methoxyphenyl)methyl)-n,n’-dimethyl-n-2-pyridinyl-2-ethanediamine n,n-dimethyl-n’-(4-methoxybenzyl)-n’-(2-pyridyl)ethylenediaminemaleate (z)-2-butenedioat 1,2-Ethanediamine,N-[(4-methoxyphenyl)methyl]-N’,N’-dimethyl-N-2-pyridinyl-,(Z)-2-butenedioate(1:1) 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)pyridinebimaleate 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridinmaleate(1:1) 2786r.p.maleate 2-ethanediamine,n-[(4-methoxyphenyl)methyl]-n’,n’-dimethyl-n-2-pyridinyl-( anisopyradamine anthisanmaleate 1,2-Ethanediamine, N-(4-methoxyphenyl)methyl-N,N-dimethyl-N-2-pyridinyl-, (2Z)-2-butenedioate (1:1) PYRILAMINEMALEATE,USP Histatex Pyrilaminmaleat 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridin maleate 2-[(2-DIMETHYLAMINOETHYL)(P-METHOXYBENZYL)AMINO]PYRIDINE MALEATE USP PYRILAMINE MALEATE USP/NF Mepyramine maleate salt, N-(4-Methoxyphenyl)methyl-Nμ,Nμ-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine maleate salt Pyrilamine Maleate (200 mg) BiMaleate N-[(4-Methoxyphenyl)Methyl]-N',N'-diMethyl-N-2-pyridinyl- 1,2-ethanediaMine (2Z)-2-Butenedioate N1-[(4-Methoxyphenyl)Methyl]-N2,N2-diMethyl-N1-2-pyridinyl-1,2-ethanediaMine (2Z)-2-Butenedioate N1-(4-Methoxybenzyl)-N2,N2-diMethyl-N1-(pyridin-2-yl)ethane-1,2-diaMine fuMarate Mepyramine maleate CRS N-(4-Methoxybenzyl)-N′,N′-dimethyl-N-(pyridin-2- yl)ethane-1,2-diamine (Z)-butenedioate N1-(4-Methoxybenzyl)-N2,N2-dimethyl-N1-(pyridin-2-yl)ethane-1,2-diamine maleate PyrilamineMaleateSal N-(4-Methoxyphenyl)methyl-N',N'-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine Maleate PYRILAMINE MALEATE USP/EP/BP Mepyramine maleateQ: What is Mepyramine maleate Q: What is the CAS Number of Mepyramine maleate Q: What is the storage condition of Mepyramine maleate Q: What are the applications of Mepyramine maleate Pyrilamine Maleate (1588004)