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Cefcapene pivoxil

Cefcapene pivoxil
Cefcapene pivoxil structure
CAS No.
105889-45-0
Chemical Name:
Cefcapene pivoxil
Synonyms
Fumax;Flumax;S-1108;CEFCAPENE PIVOXIL;Cefcapene Piroxil;Cefcapene Impurity 3;Cefcapene Pivoxil See C242555;(6R,7R)-3-[[(Aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-(2-amino-4-thiazolyl)-1-oxo-2-pentenyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid, (2,2-Dimethyl-1-oxopropoxy)methyl Ester;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,3-[[(aMinocarbonyl)oxy]Methyl]-7-[[(2Z)-2-(2-aMino-4-thiazolyl)-1-oxo-2-penten-1-yl]aMino]-8-oxo-,(2,2-diMethyl-1-oxopropoxy)Methyl ester, (6R,7R)-
CBNumber:
CB3680908
Molecular Formula:
C23H29N5O8S2
Formula Weight:
567.64
MOL File:
105889-45-0.mol

Cefcapene pivoxil Properties

Melting point:
158-164°C

SAFETY

Cefcapene pivoxil price

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Cefcapene pivoxil Chemical Properties,Uses,Production

Description

Flomox was launched in Japan as an orally active cephalosporin for respiratory and urinary tract infections, heptatic infections, ophthalmological and otorhinolarynological infections, skinkoft tissue infections, and for use in gynacology, dentistry and oral surgery. It can be prepared by condesation of 2(Z)-(2-(t-butoxycarbonylamino) thiazol-4-yl)-2-pentenoic acid with 7-amino-3-(carbanoyloxymethyl)- 3-cephem-4-carboxylic acid pivaloyl methyl ester followed by deprotection. Flomox is highly active against a wide variety of Gram-positive and Gram-negative bacteria, except for several strains such as Pseudomonas aeruginosa and enterococci, by acting as a cell wall synthesis inhibitor (β-lactamase stability against TEM-1 type β-lactamases) and is more effective than cefaclor and cefdinir. Absorption is improved by the pivaloyloxymethyl ester group which is easily lost by deesterification during GI absorption to produce the biologically active form. The pivalic acid generated quickly conjugates with carnitine and is excreted in the urine. The drop in plasma levels of carnitine was dose dependent and returned to normal levels upon termination of treatment.

Chemical Properties

Off-White Solid

Originator

Shionogi (Japan)

Uses

Antibacterial. Orally absorbed cephalosporin; ester prodrug of the active free acid metabolite, cefcapene

brand name

Flomox

Cefcapene pivoxil Preparation Products And Raw materials

Raw materials

Preparation Products


Cefcapene pivoxil Suppliers

Global( 51)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19919 60
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18
0086-571-85864795 sales@capotchem.com China 18230 66
Chemfun Medical Technology(Shanghai) Co., Ltd. 021-67220633 & 021-37212706
+86-21-67220638 chemfun@chemfun.net China 21815 59
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32365 50
XiaoGan ShenYuan ChemPharm co,ltd Tell:86-712-2580635 Mobile:15527768850 . 15527768836
86-712-2580625 QQ:1623551145 sales02@farchem.com China 9103 52
Wuhan Fortuna Chemical Co., Ltd +86-27-59207852 85767163
+86-27-59524646 info@fortunachem.com China 2756 58
Beijing HuaMeiHuLiBiological Chemical 010-56205725;010-86181995
010-65763397 waley188@sohu.com China 12343 58
NCE Biomedical Co.,Ltd. 4000-027-021 |24 hour enquiry :+86-13986109188 |English:+86-15623472865 |Japanese:+81-08033611988
+86-27-87599188 sales@ncebiomed.com China 1498 55

105889-45-0(Cefcapene pivoxil)Related Search:


  • CEFCAPENE PIVOXIL
  • (6R,7R)-3-[[(Aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-(2-amino-4-thiazolyl)-1-oxo-2-pentenyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid, (2,2-Dimethyl-1-oxopropoxy)methyl Ester
  • Fumax
  • S-1108
  • Cefcapene Piroxil
  • Flumax
  • Cefcapene Pivoxil See C242555
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,3-[[(aMinocarbonyl)oxy]Methyl]-7-[[(2Z)-2-(2-aMino-4-thiazolyl)-1-oxo-2-penten-1-yl]aMino]-8-oxo-,(2,2-diMethyl-1-oxopropoxy)Methyl ester, (6R,7R)-
  • Cefcapene Impurity 3
  • -
  • 105889-45-0
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Heterocycles
  • Metabolites & Impurities
  • Sulfur & Selenium Compounds
  • Pharmaceutical intermediate
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