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SPECTINOMYCIN DIHYDROCHLORIDE

SPECTINOMYCIN DIHYDROCHLORIDE structure

CAS No.: 21736-83-4

Chemical Name:: SPECTINOMYCIN DIHYDROCHLORIDE

Synonyms: SPECTINOMYCIN HYDROCHLORIDE;M 141;stanilo;U-18409AE;NSC 248616;Spectacomycin;SPECTINOMYCIN 2HCL;SPECTINOMYCIN DIHYDROC;Spectinomycin (50mg/ml);Methanomycin hydrochloride

CBNumber:: CB3690961

Molecular Formula:: C14H25ClN2O7

Molecular Weight:: 368.81

MDL Number:: MFCD00070403

MOL File:: 21736-83-4.mol

MSDS File:: SDS

Last updated:2024-03-25 20:41:16

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SPECTINOMYCIN DIHYDROCHLORIDE Properties

Melting point	194°C
storage temp.	Inert atmosphere,2-8°C
solubility	H₂O: 50 mg/mL, clear, faintly yellow
form	powder
color	White to Off-White
FDA UNII	296JEI210Z

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H334-H317
Precautionary statements	P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P261-P285-P304+P341-P342+P311-P501
WGK Germany	2
RTECS	WG7400000
F	10
Toxicity	monkey,LD50,oral,500mg/kg (500mg/kg),Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 7, Pg. 100, 1965.

SPECTINOMYCIN DIHYDROCHLORIDE price More Price(15)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	S680250	SpectinomycinDihydrochloride	21736-83-4	100mg	$55	2021-12-16	Buy
ChemScene	CS-2544	Spectinomycindihydrochloride ≥98.0%	21736-83-4	1g	$60	2021-12-16	Buy
ChemScene	CS-2544	Spectinomycindihydrochloride ≥98.0%	21736-83-4	5g	$90	2021-12-16	Buy
AK Scientific	2725AH	Spectinomycindihydrochloridehydrate	21736-83-4	5g	$121	2021-12-16	Buy
ChemScene	CS-2544	Spectinomycindihydrochloride ≥98.0%	21736-83-4	25g	$220	2021-12-16	Buy

Product number	Packaging	Price	Buy
S680250	100mg	$55	Buy
CS-2544	1g	$60	Buy
CS-2544	5g	$90	Buy
2725AH	5g	$121	Buy
CS-2544	25g	$220	Buy

SPECTINOMYCIN DIHYDROCHLORIDE Chemical Properties,Uses,Production

Chemical Properties

SPECTINOMYCIN DIHYDROCHLORIDE is White Powder

Uses

SPECTINOMYCIN DIHYDROCHLORIDE is an antibiotic used in the treatment and control of infectious bacterial enteritis in animals. Used in drug testing against nonreplicating mycobacterium tuberculosis.

Uses

Antibacterial;Ribosomal protein

Definition

SPECTINOMYCIN DIHYDROCHLORIDE is a hydrochloride obtained by combining spectinomycin with two molar equivalents of hydrochloric acid. An antibiotic that is active against gram-negative bacteria and used (as its pentahydrate) to treat gonorrhea.

Clinical Use

The aminocyclitol antibiotic spectinomycin hydrochloride(Trobicin), isolated from Streptomyces spectabilis andonce called actinospectocin, was first described by Lewisand Clapp. Its structure and absolute stereochemistryhave been confirmed by x-ray crystallography. It occursas the white, crystalline dihydrochloride pentahydrate,which is stable in the dry form and very soluble in water.Solutions of spectinomycin, a hemiacetal, slowly hydrolyzeon standing and should be prepared freshly andused within 24 hours. It is administered by deep intramuscularinjection.
Spectinomycin is a broad-spectrum antibiotic withmoderate activity against many Gram-positive and Gramnegativebacteria. It differs from streptomycin and thestreptamine-containing aminoglycosides in chemical and antibacterialproperties. Like streptomycin, spectinomycininterferes with the binding of transfer RNA (tRNA) to the ribosomesand thus with the initiation of protein synthesis.Unlike streptomycin or the streptamine-containing antibiotics,however, it does not cause misreading of the messenger.Spectinomycin exerts a bacteriostatic action and isinferior to other aminoglycosides for most systemic infections.Currently, it is recommended as an alternative to penicillinG salts for the treatment of uncomplicated gonorrhea.A cure rate of more than 90% has been observed in clinicalstudies for this indication. Many physicians prefer to use atetracycline or erythromycin for prevention or treatment ofsuspected gonorrhea in penicillin-sensitive patients because,unlike these agents, spectinomycin is ineffective againstsyphilis. Furthermore, it is considerably more expensive thanerythromycin and most of the tetracyclines.

Safety Profile

Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx and HCl.

Purification Methods

The salt is purified by recrystallisation from aqueous Me2CO and is soluble in H2O, MeOH and dilute acid and base, but only slightly soluble in Me2CO, EtOH, CHCl3 and *C6H6. The free base is an amorphous solid, m 184-194o with []D -20o (H2O). [Wiley et al. J Am Chem Soc 93 2652 1963, X-ray: Cochran et al. J Chem Soc Chem Commun 494 1972.] It is an aminoglycoside antibiotic which interacts with 16S ribosomal RNA [Moazet & Noller Nature 327 389 1987] and is used for the treatment of gonorrhea [Rinehart J Infect Dis 119 345 1969].

SPECTINOMYCIN DIHYDROCHLORIDE synthesis

Synthesis of SPECTINOMYCIN DIHYDROCHLORIDE from Carbamic acid, [4-(acetyloxy)decahydro-4a,7,9-trihydroxy-2-methyl-2H-pyrano[2,3-b][1,4]benzodioxin-6,8-diyl]bis[methyl-, bis(phenylmethyl) ester, [2R-(2α,4β,4aβ,5aβ,6α,7α,8α,9β,9aβ,10aβ)]- (9CI)

SPECTINOMYCIN DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Carbamic acid, [4-(acetyloxy)decahydro-4a,7,9-trihydroxy-2-methyl-2H-pyrano[2,3-b][1,4]benzodioxin-6,8-diyl]bis[methyl-, bis(phenylmethyl) ester, [2R-(2α,4β,4aβ,5aβ,6α,7α,8α,9β,9aβ,10aβ)]- (9CI)

Preparation Products

SPECTINOMYCIN DIHYDROCHLORIDE Suppliers

Global( 275)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Jiangsu Guotai Guomian Trading Co. Ltd.	+86-512-58916079 +86-13601562190	pharmachem@gtgmt.com	China	148	58
shandong perfect biotechnology co.ltd	+86-53169958659; +8618596095638	sales@sdperfect.com	China	294	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+86-13474506593 +86-13474506593	sarah@tnjone.com	China	794	58
Hubei XinRunde Chemical Co., Ltd.	+8615102730682	bruce@xrdchem.cn	CHINA	566	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Shaanxi Yikanglong Biotechnology Co., Ltd.	17791478691	yklbiotech@163.com	CHINA	296	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8822	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58

Supplier	Advantage
Jiangsu Guotai Guomian Trading Co. Ltd.	58
shandong perfect biotechnology co.ltd	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
Hubei XinRunde Chemical Co., Ltd.	55
career henan chemical co	58
Shaanxi Yikanglong Biotechnology Co., Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Hebei Guanlang Biotechnology Co., Ltd.	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from SPECTINOMYCIN DIHYDROCHLORIDE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-16	SpectinoMycin Dihydrochloride 21736-83-4	US $0.00-0.00 / kg	1kg	784U/mg	1000kg	Hebei ZB Gamay Biological Technology Co.,Ltd
2024-03-25	Spectinomycin Hydrochloride 21736-83-4	US $0.00 / kg	1kg	99%	5000kg	Shaanxi TNJONE Pharmaceutical Co., Ltd
2024-03-16	Spectinomycin Dihydrochloride 21736-83-4	US $0.00 / KG	100g	98%+	100kg	WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

SpectinoMycin Dihydrochloride
21736-83-4
US $0.00-0.00 / kg
784U/mg
Hebei ZB Gamay Biological Technology Co.,Ltd

Spectinomycin Hydrochloride
21736-83-4
US $0.00 / kg
99%
Shaanxi TNJONE Pharmaceutical Co., Ltd

Spectinomycin Dihydrochloride
21736-83-4
US $0.00 / KG
98%+
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

SPECTINOMYCIN DIHYDROCHLORIDE Spectrum

SPECTINOMYCIN DIHYDROCHLORIDE(21736-83-4)MS

21736-83-4(SPECTINOMYCIN DIHYDROCHLORIDE)Related Search:

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8-beta,9-alpha,9a-alpha,10a-beta))-t 8-bis(methylamino)-,dihydrochloride,(2r-(2-alpha,4a-beta,5a-beta,6-beta,7-be (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-decahydro-4a,7,9-trihydroxy-2-Methyl-6,8-bis(MethylaMino)-4H-pyrano[2,3-b][1,4]benzodioxin-4-one Hydrochloride SpectinoMycinHydrochloride for Injection 4H-Pyrano[2,3-b][1,4]benzodioxin-4-one,decahydro-4a,7,9-trihydroxy-2-Methyl-6,8-bis(MethylaMino)-, hydrochloride(1:2), (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)- (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-4H-pyrano[2,3-b][1,4]benzodioxin-4-one, hydrochloride (1:2) U-18409AE SPECTINOMYCIN DIHYDROCHLORIDE SPECTINOMYCIN 2HCL ACTINOSPECTACIN DIHYDROCHLORIDE stanilo SPECTINOMYCIN READY MADE SOLUTION Spectinomycin2HClpentahydrate SPECTINOMYCINHYDROCHLORIDEANHYDROUS 4H-Pyrano[2,3-b][1,4]benzodioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-, dihydrochloride, (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)- (9CI) 4H-Pyrano[2,3-b][1,4]benzodioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-, dihydrochloride, [2R-(2a,4ab,5ab,6b,7b,8b,9a,9aa,10ab)]- (8CI) NSC 248616 M 141 Raw Material Spectinomycin Dihydrochloride / Spectinomycin HCL CAS 21736-83-4 Spectinomycin dihydrochloride, >98% SPECTINOMYCIN DIHYDROC Spectinomycin Hydrochloride and Lincomycin Hydrochloride Soluble Powder SPECTINOMYCIN DIHYDROCHLORIDE USP/EP/BP (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-4a,7,9-Trihydroxy-2-methyl-6,8-bis(methylamino)decahydro-4H-benzo[b]pyrano[2,3-e][1,4]dioxin-4-one dihydrochloride SPECTINOMYCIN HYDROCHLORIDE Methanomycin hydrochloride Spectinomycin (50mg/ml) Spectacomycin (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)octahydro-2H-benzo[b]pyrano[2,3-e][1,4]dioxin-4(3H)-one hydrochloride 21736-83-4 21736-83-5 C14H26Cl2N2O7 C14H24N2O72ClH C14H24N2O7HClH2O C14H25ClN2O7 BioChemical Antibiotics N-S Antibiotics A to Z Antibiotics Inhibitors Aliphatics Amines Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Active Pharmaceutical Ingredients