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D-(+)-Pantothenic acid calcium salt

Production method Uses Toxicity Usage limit Chemical properties Hazards & Safety Information
D-(+)-Pantothenic acid calcium salt
D-(+)-Pantothenic acid calcium salt structure
CAS No.
137-08-6
Chemical Name:
D-(+)-Pantothenic acid calcium salt
Synonyms
pancal;Calpan;(theta)-;Pantholin;NSC 36292;calpanate;VITAMIN B5;panthoject;DL-Calcium;VITAMIN B3/B5
CBNumber:
CB3695335
Molecular Formula:
C18H32CaN2O10
Formula Weight:
476.53
MOL File:
137-08-6.mol

D-(+)-Pantothenic acid calcium salt Properties

Melting point:
190 °C
alpha 
26.5 º (c=5, in water)
refractive index 
27 ° (C=5, H2O)
Flash point:
145 °C
storage temp. 
2-8°C
solubility 
H2O: 50 mg/mL at 25 °C, clear, nearly colorless
form 
Powder
color 
White or almost white
PH
6.8-7.2 (25℃, 50mg/mL in H2O)
optical activity
[α]20/D +27±2°, c = 5% in H2O
Water Solubility 
Soluble in water.
Sensitive 
Hygroscopic
Merck 
14,7015
BRN 
3769272
Stability:
Stable, but may be moisture or air sensitive. Incompatible with strong acids, strong bases.
InChIKey
FAPWYRCQGJNNSJ-UBKPKTQASA-L
CAS DataBase Reference
137-08-6(CAS DataBase Reference)
EPA Substance Registry System
.beta.-Alanine, N-[(2R)-2,4-dihydroxy-3,3- dimethyl-1-oxobutyl]-, calcium salt (2:1)(137-08-6)

SAFETY

Hazard Codes  Xn
Risk Statements  20/21/22-37/38-41-48
Safety Statements  24/25-45-36/37/39-26-22
WGK Germany  1
RTECS  RU4375000
3-10
TSCA  Yes
HS Code  29362400

D-(+)-Pantothenic acid calcium salt price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 21210 D-Pantothenic acid hemicalcium salt ≥98.0% 137-08-6 5g-f $27.8 2018-11-13 Buy
Sigma-Aldrich 1087009 Calcium Pantothenate United States Pharmacopeia (USP) Reference Standard 137-08-6 200mg $357.7 2018-11-13 Buy
TCI Chemical P0012 Calcium D-Pantothenate >98.0%(T) 137-08-6 25g $22 2018-11-22 Buy
TCI Chemical P0012 Calcium D-Pantothenate >98.0%(T) 137-08-6 100g $50 2018-11-22 Buy
Alfa Aesar A16609 D-Pantothenic acid calcium salt, 98% 137-08-6 100g $37 2018-11-13 Buy

D-(+)-Pantothenic acid calcium salt Chemical Properties,Uses,Production

Production method

Take isobutyraldehyde as raw material; carry out hydroxymethylation, addition reaction, hydrolysis, acidification, lactonization and acylation to derive the final product.
Formaldehyde and anhydrous potassium carbonate are sent into the reaction pot. At 14-20 °C, it is added dropwise of isobutyraldehyde. After the completion of the addition, incubate for stirring reaction for 3h, and then stand at 14-18 °C for 0.5 h to obtain the upper oil-2, 2-dimethyl-3-hydroxypropionaldehyde.
2, 2-dimethyl-3-hydroxypropanal is dissolved in 4 times the water while the sodium cyanide is dissolved in 6 times the water and calcium chloride dissolved in 2 times the water. The above solutions are successively added into the reaction pot. 50% sulfuric acid solution was added under stirring at 60-65 ° C for 6h; then being heated to 80-85 °C for 3h and subject to vacuum concentration to being thick. 95% ethanol was added to precipitate the inorganic salt and filtrate. After the recovery of ethanol through distillation under reduced pressure, collect the fractions of 130-145C (1.33-2.39 Kpa), namely ?-butyrolactone.
Then, β-aminopropionic acid, 5/6 methanol and lime were successively added to the reactor. Raise the temperature to 40 °C, and the reaction was stirred for 2 hours. The reaction mixture was allowed to stand for while before the supernatant was filtered by filtration. The solid residue in the pot was washed with 1/6 methanol and then filtered. The filtrate is placed in another reaction pot, being added of γ-butyrolactone for stirring and dissolving in room temperature for 40 h reaction to generate calcium pantothenate. Stirring with water and cooling to-5-0 °C, and add seed crystal for stirring of 24 hours, filter to obtain the dextro calcium pantothenate.
2/3 the amount of calcium pantothenate and calcium p-pantothenate are thrown into the reaction pot; add methanol and water, heat to 40 °C for stirring dissolving and filter upon being hot. The filtrate is cooled to 15 °C, added of a small amount of calcium L-pantothenate and crystal for 2h. When the specific rotation is up to +6 °-+8 °, separate the crystal, and wash with a small amount of methanol to obtain the L-calcium p-pantothenate (still used for resolution). The remaining 1/3 racemic calcium pantothenate was dissolved in a filtrate of 35-40 ° C, filtered and cooled to 15 ° C. A small amount of calcium p-pantothenate was added and the crystals were incubated for 2 hours. Crystals were separated when the specific rotation was-0.8 °--0.6 °, washed with a small amount of methanol and dried in vacuo to give calcium dextrate.
It is derived through the heating and condensation between calcium β-alanine and α-hydroxy β, β-dimethyl-γ-butyl ester.

Uses

1.    It can be applied to biochemical studies; as the nutrient composition of tissue culture medium. It is clinically used for the treatment of vitamin B deficiency, peripheral neuritis and postoperative colic.
2.    It can be used as food fortifier, also used as infant food with the usage amount of 15~28 mg/kg; it is 2~4mg/kg in the drink.
3.    This product is a vitamin drugs, being an integral part of coenzyme A. In the mixture of calcium pantothenate, only the right-hand body has vitamin activity, participating into the in vivo metabolism of protein, fat and carbohydrate. It can be used for the treatment of vitamin B deficiency and peripheral neuritis, and postoperative colic. Its combined treatment with vitamin C can be used for the treatment of disseminated lupus erythematosus. The lack of calcium pantothenate in human body has the following symptoms: (1) growth arrest, weight loss and sudden death. (2) Skin and hair disorders. (3) Neurological disorders. (4) Digestive disorders, liver dysfunction. (5) Affect the antibody formation. (6) Kidney dysfunction. Every day the body demands 5 mg of calcium pantothenate (calculated based on pantothenic acid). Calcium pantothenate, as a nutritional supplement, can be used for the food processing. In addition to special nutritional food, the usage amount should be below 1% (calculated on calcium) (Japan). Upon the strengthening of the milk powder, the usage amount should be 10 mg/100g. Addition of 0.02% into the Shochu and whiskey can further enhance the flavor. Addition of 0.02% into the honey can prevent the winter crystallization. It can be used for buffering the bitterness of caffeine and saccharin.
4.    It can be used as feed additives, food additives, being in line with Pharmacopoeia USP28/BP2003
5.    It can be used as nutritional supplements, being able to enhance the flavor of shochu whiskey to prevent the crystallization of honey in winter.
6.    It is the precursor product for the biosynthesis of coenzyme A. Because of the easy-deliquescence of pantothenic acid and other unstable properties, it is used of calcium salt as the substitute.

Toxicity

LD50>10 g/kg (rat, oral);
GRAS (FDA, § 182.5212, §184.1212, 2000);

Usage limit

GMP as the limit (FDA &184.1212, 2000);
1% in general food (calculated based on calcium excluding special nutritional supplements; Japan, 1993);

Chemical properties

It appears as white crystalline (methanol), being hygroscopic; it is stable to the light and air with its aqueous solution being weakly alkaline. Its Mp is 195-196 °C (decomposition); Specific rotation [α] 26D + 28.2 ° (5%, water); It is soluble in water and glycerol, being slightly soluble in acetone and ethanol;

Hazards & Safety Information

Category: Toxic substances
Toxicity classification: Low toxicity
Acute toxicity: Oral-rat LD50: 10000 mg/kg; oral-mouse LD50: 10000 mg/kg
Flammability and Hazardous characteristics: Thermal decomposition releases toxic nitrogen oxides
Storage and transport characteristics Treasury: low temperature, ventilated and dry
Fire extinguishing agent:  water, carbon dioxide, dry powder, foam

Chemical Properties

white crystalline powder

Uses

A member of the B complex vitamins; essential vitamin for the biosynthesis of coenzyme A in mammalian cells. Occurs ubiquitously in all animal and plant tissue. The richest common source is liver, but jelly of the queen bee contains 6 times as much as liver. Rice bran and molasses are other good sources.

Uses

calcium pantothenate is used as an emollient and to enrich creams and lotions in hair care preparations. This is the calcium salt of pantothenic acid found in liver, rice, bran, and molasses. It is also found in large amounts in royal jelly.

Uses

Calcium Pantothenate is a nutrient and dietary supplement which is the calcium chloride double salt of . It is a white powder of bitter taste and has a solubility of 1 g in 3 ml of water. It is used in special dietary foods.

brand name

Calpan (BASF); Pantholin (Lilly).

General Description

The first suggestion for the existance of vitamin B5 came from Carter et al. in 1930; although it was never characterized or isolated. This vitamin is synthesized by most green plants and microorganisms. Excellent sources of the vitamin are liver, egg yolk, whole grains, and fortified ready-to-eat cereals. However, as the original name implies, many foods contain sufficient pantothenic acid to supply dietary needs.
Chemically, pantothenic acid is considered to be aβ-alanine derivative of the asymmetric pantoic acid and thus shows asymmetry. Only the naturally occurring D(+)- stereoisomer (with R configuration) is biologically active and the L(-)-stereoisomer (with S configuration) is inactive. When its carboxylate functional group is attached through an amide linkage with β-mercaptoethylamine, it is known as pantetheine (also spelled pantotheine). The biologically active form of pantothenic acid, CoA, is formed when the terminal alcoholic function of pantetheine is attached to ADP 3'-phosphate.

Clinical Use

The only therapeutic indication for pantothenic acid is intreatment of a known or suspected deficiency of this vitamin.Because of the ubiquitous nature of pantothenic acid, deficiencystates of this vitamin are only seen experimentally byuse of synthetic diets devoid of the vitamin, by use of thevitamin antagonist, ω-methylpantothenic, or both. In a 1991review, Tahiliani and Beinlich described that the mostcommon symptoms associated with pantothenic acid deficiencywere headache, fatigue, and a sensation of weakness.Sleep disturbances and gastrointestinal disturbances, amongothers, were also noted. The most likely setting for pantothenicacid deficiency is in the setting of alcoholism wherea multiple vitamin deficiency exists confounding the exactrole of the pantothenic acid deficiency as compared to theother vitamins. Because a deficiency of a single B vitamin israre, pantothenic acid is commonly formulated in multivitaminor B-complex preparations.

Safety Profile

Moderately toxic by intraperitoneal, subcutaneous, and intravenous routes. Mildly toxic by ingestion. A vitamin. See also CALCIUM COMPOUNDS. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

The salt crystallises as needles from MeOH, EtOH or isoPrOH (with 0.5mol of isoPrOH). It is moderately hygroscopic. The S-benzylisothiuronium salt has m 151-152o (149o when crystallised from Me2CO). [Kagan et al. J Am Chem Soc 79 3545 1957, Wilson et al. J Am Chem Soc 76 5177 1954, Stiller & Wiley J Am Chem Soc 63 1239 1941, Beilstein 4 IV 2569.]

D-(+)-Pantothenic acid calcium salt Preparation Products And Raw materials

Raw materials

Preparation Products


D-(+)-Pantothenic acid calcium salt Suppliers

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View Lastest Price from D-(+)-Pantothenic acid calcium salt manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-04-03 Calcium pantothenate (Vitamin B5;D-PANTOTHENIC ACID CALCIUM SALT) in stock GMP Factory
137-08-6
US $1.00 / KG 1KG GMP Factory in China Top 3 largest production capacity Factory Chemwill Asia Co.,Ltd.
2018-08-06 D-(+)-Pantothenic acid calcium salt
137-08-6
US $1.00 / KG 1KG 98% 1 career henan chemical co
2018-07-26 D-(+)-Pantothenic acid calcium salt
137-08-6
US $100.00-90.00 / KG 1KG 99% Customized career henan chemical co

D-(+)-Pantothenic acid calcium salt Spectrum


137-08-6(D-(+)-Pantothenic acid calcium salt)Related Search:


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