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Afloqualone

Afloqualone
Afloqualone structure
CAS No.
56287-74-2
Chemical Name:
Afloqualone
Synonyms
H-495;aroft;HQ-495;HQ 495;arofuto;Aoqualone;AFLOQUALONE;Afloquanone;Afloqualone USP/EP/BP;6-aMino-2-fluoroMethyl-3-(o-tolyl)-4(3h)-quinaz...
CBNumber:
CB3699964
Molecular Formula:
C16H14FN3O
Formula Weight:
283.3
MOL File:
56287-74-2.mol

Afloqualone Properties

Melting point:
195-196°C
Boiling point:
492.5±55.0 °C(Predicted)
Density 
1.2529 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
pka
2.73±0.70(Predicted)
CAS DataBase Reference
56287-74-2(CAS DataBase Reference)
FDA UNII
CO4U2C8ORZ
SAFETY
  • Risk and Safety Statements
Toxicity LD50 in mice (mg/kg): 315.1 i.p. (Tani)

Afloqualone price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 21834 Afloqualone ≥98% 56287-74-2 1mg $65 2021-03-22 Buy
Cayman Chemical 21834 Afloqualone ≥98% 56287-74-2 5mg $292 2021-03-22 Buy

Afloqualone Chemical Properties,Uses,Production

Description

Afloqualone is a centrally acting muscle relaxant useful in the management of various spastic conditions, including cerebral palsy, cervical spondylosis, and multiple sclerosis. It is closely related to the hypnotidsedative methaqualone.

Originator

Tanabe (Japan)

Manufacturing Process

14.4 g (0.053 mol) of N-(2-amino-5-nitrobenzoyl)-o-toluidine and 6.3 g (0.08 mol) of pyridine are dissolved in 300 ml of tetrahydrofuran. 12.2 g (0.126 mol) of fluoroacetyl chloride are added to the solution for 10 minutes under ice-cooling. The solution is stirred at the same temperature for 30 minutes and then at room temperature for 2.5 hours. The reaction solution is allowed to stand at room temperature overnight. The crystalline precipitate is collected by filtration, washed with water and then dried. 16.4 g of N-(2- fluoroacetamido-5-nitrobenzoyl)-o-toluidine are obtained. Yield: 93.7%; MP 238-239°C.
16.5 g (0.05 mol) of N-(2-fluoroacetamido-5-nitrobenzoyl)-o-toluidine and 25.5 g (0.25 mol) of acetic acid anhydride are dissolved in 250 ml of glacial acetic acid. The solution is refluxed for 2 hours under heating. Then, the reaction solution is evaporated to remove solvent. The residue thus obtained is poured into ice-water, and the aqueous mixture is adjusted to pH 9 with potassium carbonate. The crystalline precipitate is collected by filtration. 15.5 g of 2-fluoromethyl-3-(o-tolyl)-6-nitro-4(3H)-quinazolinone are obtained. Yield: 98.7%; MP 155-158°C (recrystallized from ethanol).
A mixture of 2.0 g (0.064 mol) of 2-fluoromethyl-3-(o-tolyl)-6-nitro-4(3H)- quinazolinone, 0.2 g of 5% palladium-carbon and 100 ml of acetic acid is shaken for 30 minutes in hydrogen gas. The initial pressure of hydrogen gas is adjusted to 46 lb and the mixture is heated with an infrared lamp during the reaction. After 30 minutes of this reaction, the pressure of hydrogen gas decreases to 6 lb. After the mixture is cooled, the mixture is filtered to remove the catalyst. The filtrate is evaporated to remove acetic acid, and the residue is dissolved in chloroform. The chloroform solution is washed with 5% aqueous sodium hydroxide and water, successively. Then, the solution is dried and evaporated to remove solvent. The oily residue thus obtained is dissolved in 2 ml of chloroform, and the chloroform solution is passed through a column of 200 g of silica gel. The silica gel column is eluted with ethyl acetatebenzene (1:1). Then, the eluate is evaporated to remove solvent. The crude crystal obtained is washed with isopropyl ether and recrystallized from isopropanol. 0.95 g of 2-fluoromethyl-3-(o-tolyl)-6-amino-4(3H)-quinazolinone is obtained. Yield: 52.5%; MP 195-196°C.

brand name

AROFUTO

Therapeutic Function

Muscle relaxant

Afloqualone Preparation Products And Raw materials

Raw materials

Preparation Products


Afloqualone Suppliers

Global( 117)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20903 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Shanghai Time Chemicals CO., Ltd.
+8618017249410 +86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47498 58
Fuxin Pharmaceutical
021-50872116
contact@fuxinpharm.com CHINA 9520 58
SIMAGCHEM CORP
13806087780 +86 13806087780
shaobowang@simagchem.com CHINA 17453 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19232 58

View Lastest Price from Afloqualone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-08 Afloqualone USP/EP/BP
56287-74-2
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
2019-07-06 Afloqualone
56287-74-2
US $1.00 / kg 1kg 99% 100KG career henan chemical co

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