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Sieber Linker

CAS No.
3722-51-8
Chemical Name:
Sieber Linker
Synonyms
HF;3-Hydroxy-9H-xanthen-9-one;Sibur linker;SIEBER LINKER;3-HYDROXYXANTHONE;6-HYDROXY-3-FLUORONE;SALOR-INT L254835-1EA;3-HYDROXY-XANTHEN-9-ONE;SIEBER LINKER, 99% MIN.;3-hydroxy-9H-9-xanthenone
CBNumber:
CB3710805
Molecular Formula:
C13H8O3
Molecular Weight:
212.2
MDL Number:
MFCD00604748
MOL File:
3722-51-8.mol
MSDS File:
SDS
Last updated:2023-09-19 11:14:51

Sieber Linker Properties

Melting point 243 °C
Boiling point 403.9±24.0 °C(Predicted)
Density 1.395±0.06 g/cm3(Predicted)
storage temp. Store at 0°C
solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka 7.52±0.20(Predicted)
form Solid
color White to Orange to Green
InChI InChI=1S/C13H8O3/c14-8-5-6-10-12(7-8)16-11-4-2-1-3-9(11)13(10)15/h1-7,14H
InChIKey XCJHDJAODLKGLG-UHFFFAOYSA-N
SMILES C1(=O)C2=C(C=CC=C2)OC2=C1C=CC(O)=C2
CAS DataBase Reference 3722-51-8(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
HS Code  29329900
NFPA 704
1
0 0

Sieber Linker price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical H1269 3-Hydroxyxanthen-9-one >98.0%(HPLC)(T) 3722-51-8 1g $35 2024-03-01 Buy
TCI Chemical H1269 3-Hydroxyxanthen-9-one >98.0%(HPLC)(T) 3722-51-8 5g $107 2024-03-01 Buy
Alfa Aesar H63495 3-Hydroxyxanthone, 98% 3722-51-8 1g $49 2022-04-27 Buy
Alfa Aesar H63495 3-Hydroxyxanthone, 98% 3722-51-8 5g $191 2022-04-27 Buy
Usbiological 241959 Sieber Linker 3722-51-8 1g $192 2021-12-16 Buy
Product number Packaging Price Buy
H1269 1g $35 Buy
H1269 5g $107 Buy
H63495 1g $49 Buy
H63495 5g $191 Buy
241959 1g $192 Buy

Sieber Linker Chemical Properties,Uses,Production

Chemical Properties

White to off-white or grey powder

Uses

Sieber linker (3-Hydroxyxanthen-9-one) is a natural product of the trifluoroacetic acid group found in Hypericum sampsonii and Rhachidosorus mesosorus. It has antiplatelet and anti-inflammatory properties. It also inhibits the expression of tumour necrosis factor-α (TNF-α) in mice. The synthesis of TNF-α is inhibited by Sieber linker, which may be due to its ability to inhibit the enzyme phosphodiesterase 4 (PDE4). Sieber linker also inhibits the binding of PDL1 to dinucleotide phosphate (DNP) and has an inhibitory effect on cancer cells. This molecule can be used for the treatment of infectious diseases, such as malaria and tuberculosis, since it inhibits protein synthesis in bacteria.

Synthesis Reference(s)

Tetrahedron, 43, p. 3075, 1987 DOI: 10.1016/S0040-4020(01)86849-6

Purification Methods

Purify the xanthone by chromatography on SiO2 gel with pet ether/*benzene as eluent. Recrystallise it from *benzene or EtOH. The acetate has m 157-158o. [Itoh et al. J Am Chem Soc 107 4819 1985, Davies et al. J Org Chem 23 307 1958]. [Beilstein 18 H 46, 18 I 315, 18 II 29, 21 III/IV 601.]

69-72-7
108-46-3
3722-51-8
Synthesis of Sieber Linker from Salicylic acid and Resorcinol
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View Lastest Price from Sieber Linker manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SieberLinker pictures 2023-08-30 SieberLinker
3722-51-8
US $70344.80-5944827.00 / kg 100kg 99% 10 tons Suzhou Eebetter Biotechnology Co., Ltd.
Sieber Linker pictures 2022-09-23 Sieber Linker
3722-51-8
US $0.00-0.00 / KG 1KG 98% 1ton Henan Aochuang Chemical Co.,Ltd.
Sieber Linker pictures 2021-07-13 Sieber Linker
3722-51-8
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
  • SieberLinker pictures
  • SieberLinker
    3722-51-8
  • US $70344.80-5944827.00 / kg
  • 99%
  • Suzhou Eebetter Biotechnology Co., Ltd.
  • Sieber Linker pictures
  • Sieber Linker
    3722-51-8
  • US $0.00-0.00 / KG
  • 98%
  • Henan Aochuang Chemical Co.,Ltd.
  • Sieber Linker pictures
  • Sieber Linker
    3722-51-8
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
SIEBER LINKER SALOR-INT L254835-1EA 6-HYDROXY-3-FLUORONE 3-HYDROXY-XANTHEN-9-ONE 3-HYDROXYXANTHONE SIEBER LINKER,3-HYDROXY-XANTHEN-9-ONE 3-HYDROXY-XANTHEN-9-ONE SIEBER LINKER 99+% SIEBER LINKER, 99% MIN. 3-hydroxy-9H-9-xanthenone 3-Hydroxy-9H-xanthen-9-one ,97% Sieber linker≥ 99% (HPLC) 3-Hydroxyxanthen-9-one> 9H-Xanthen-9-one, 3-hydroxy- Sieber Linker (3-Hydroxyxanthone) extrapure, 99% HF 3-Hydroxy-9H-xanthen-9-one Sibur linker 3722-51-8 Linkers for Solid Phase Synthesis Linkers for solid phase synthesis linker