Torcetrapib
- CAS No.
- 262352-17-0
- Chemical Name:
- Torcetrapib
- Synonyms
- cp529;CS-156;CP 529414;Torcetropib;Torcetrapib;TORCETRAPIB-D3;Torcetrapib USP/EP/BP;Torcetrapib (CP-529414);(2R,4S)-ethyl 2-ethyl-4-(methoxycarbonyl)-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate;(2R)-ethyl 4-((3,5-bis(trifluoroMethyl)benzyl)(Methoxycarbonyl)aMino)-2-ethyl-6-(trifluoroMethyl)-3,4-dihydroquinoline-1(2H)-carboxylate
- CBNumber:
- CB3739389
- Molecular Formula:
- C26H25F9N2O4
- Molecular Weight:
- 600.47
- MDL Number:
- MFCD09260777
- MOL File:
- 262352-17-0.mol
- MSDS File:
- SDS
| Melting point | 54-58°C |
|---|---|
| Boiling point | 504.8±50.0 °C(Predicted) |
| Density | 1.42 |
| storage temp. | Store at RT |
| solubility | DMSO: >5mg/mL |
| pka | -1.87±0.40(Predicted) |
| form | powder |
| color | white |
| optical activity | [α]/D >-70° |
| CAS DataBase Reference | 262352-17-0(CAS DataBase Reference) |
| FDA UNII | 4N4457MV2U |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264; P270; P301+P312; P330; P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
Torcetrapib price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PZ0170 | Torcetrapib ≥98% (HPLC) | 262352-17-0 | 5mg | $153 | 2024-03-01 | Buy |
| Sigma-Aldrich | PZ0170 | Torcetrapib ≥98% (HPLC) | 262352-17-0 | 25mg | $437 | 2024-03-01 | Buy |
| Cayman Chemical | 15028 | Torcetrapib ≥98% | 262352-17-0 | 5mg | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 15028 | Torcetrapib ≥98% | 262352-17-0 | 10mg | $137 | 2024-03-01 | Buy |
| Cayman Chemical | 15028 | Torcetrapib ≥98% | 262352-17-0 | 50mg | $577 | 2024-03-01 | Buy |
Torcetrapib Chemical Properties,Uses,Production
Chemical Properties
Off-White Low Melting Solid
Uses
Cholesteryl ester transfer protein (CETP) inhibitor. Antilipemic; antiatherosclerotic.
Definition
ChEBI: Torcetrapib is a member of quinolines, a carbamate ester and a member of (trifluoromethyl)benzenes. It has a role as an anticholesteremic drug and a CETP inhibitor.
Biological Activity
torcetrapib is a cetp inhibitor with ic50 of 37 nm, elevates hdl-c and reduces nonhdl-c in plasma. inhibition of cholesteryl ester transfer protein (cetp) has been shown to have a substantial effect on plasma lipoprotein levels.
in vitro
torcetrapib dose-dependently increases aldosterone release from h295r cells after either 24 or 48 h of treatment, this effect is mediated by calcium channel as calcium channel blockers completely blocks torcetrapib-induced corticoid release and calcium increase. torcetrapib (1 μm) significantly increases the expression of steroidogenic gene, cyp11b2 and cyp11b1, in h295r cell lines [1].
in vivo
researchers tested torcetrapib in rabbits fed an atherogenic diet at a dose sufficient to increase hdl-c by at least 3-fold. cetp activity was inhibited by 70–80% throughout the study. non-hdl-c increased in both groups, but there was no difference apparent by the study’s end [2].
storage
Room temperature
References
[1] hu x, dietz jd, xia c, knight dr, loging wt, smith ah, yuan h, perry da, keiser j. torcetrapib induces aldosterone and cortisol production by an intracellular calcium-mediated mechanism independently of cholesteryl ester transfer protein inhibition. endocrinology. 2009;150(5):2211-9.
[2] morehouse la, sugarman ed, bourassa pa, sand tm, zimetti f, gao f, rothblat gh, milici aj. inhibition of cetp activity by torcetrapib reduces susceptibility to diet-induced atherosclerosis in new zealand white rabbits. j lipid res. 2007;48(6):1263-72.
[3] barter pj, caulfield m, eriksson m, grundy sm, kastelein jj, komajda m, lopez-sendon j, mosca l, tardif jc, waters dd, shear cl, revkin jh, buhr ka, fisher mr, tall ar, brewer b; illuminate investigators. effects of torcetrapib in patients at high risk for coronary events. n engl j med. 2007;357(21):2109-22.
Torcetrapib Preparation Products And Raw materials
Raw materials
Preparation Products
Torcetrapib Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3632 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19639 | 58 |
View Lastest Price from Torcetrapib manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-20 | Torcetrapib
262352-17-0
|
US $0.00-0.00 / KG | 1g | 99% | 2000tons | Shaanxi Dideu Medichem Co. Ltd |
-
- Torcetrapib
262352-17-0
- US $0.00-0.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd