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Description Chemical and Physical properties Preparation Precautions Hazard Statements
1,2-Ethanedithiol structure
Chemical Name:
EDT;EDT(L);FEMA 3484;DITHIOGLYCOL;ETHANEDITHIOL;EDT, 98% MIN.;EDT)1,2-Ethane;Ethylenedithiol;1,2-Ethanethiol;1-ETHANEDITHIOL
Molecular Formula:
Formula Weight:
MOL File:

1,2-Ethanedithiol Properties

Melting point:
−41 °C(lit.)
Boiling point:
144-146 °C(lit.)
1.123 g/mL at 25 °C(lit.)
vapor density 
>1 (vs air)
vapor pressure 
4.8 mm Hg ( 20 °C)
refractive index 
n20/D 1.558(lit.)
Flash point:
122 °F
storage temp. 
Store at 0-5°C
pK1:8.96;pK2:10.54 (25°C)
Clear slightly colored
Water Solubility 
Air Sensitive
JECFA Number
Stable. Flammable. Incompatible with oxidizing agents, bases, reducing agents, alkali metals.
CAS DataBase Reference
540-63-6(CAS DataBase Reference)
NIST Chemistry Reference
EPA Substance Registry System
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T,Xn,F
Risk Statements  10-23/24/25-23/25-21-36-23-21/22-36/37/38-20/21/22
Safety Statements  36/37/39-45-26-16-36/37-36-7/9
RIDADR  UN 3071 6.1/PG 2
WGK Germany  3
RTECS  KI3325000
HazardClass  3
PackingGroup  III
HS Code  29309070
Hazardous Substances Data 540-63-6(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: 120 mg/kg LD50 dermal Rabbit 197 mg/kg
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H226 Flammable liquid and vapour Flammable liquids Category 3 Warning
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning P280,P302+P352, P312, P322, P363,P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H330 Fatal if inhaled Acute toxicity,inhalation Category 1, 2 Danger P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P320 Specific treatment is urgent (see … on this label).
P330 Rinse mouth.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P370+P378 In case of fire: Use … for extinction.
P405 Store locked up.

1,2-Ethanedithiol price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 02390 1,2-Ethanedithiol ≥98.0% (GC) 540-63-6 25ml $26.1 2018-11-13 Buy
Sigma-Aldrich 02390 1,2-Ethanedithiol ≥98.0% (GC) 540-63-6 100ml $54.3 2018-11-13 Buy
TCI Chemical E0032 1,2-Ethanedithiol >99.0%(GC) 540-63-6 25g $30 2018-11-22 Buy
TCI Chemical E0032 1,2-Ethanedithiol >99.0%(GC) 540-63-6 100g $109 2018-11-22 Buy
Alfa Aesar L12865 1,2-Ethanedithiol, 98+% 540-63-6 100g $59.7 2018-11-13 Buy

1,2-Ethanedithiol Chemical Properties,Uses,Production


1,2-Ethanedithiol (EDT) is a colorless liquid with a characteristic odor that resembles that of rotten cabbage. It is widely used as a building block in organic synthesis, and it is also an effective ligand for metal ions. 1,2-ethanedithiol if applied as a flavoring agent and it is available in a variety of animal foods, in cooked beef and chicken.

Chemical and Physical properties

1, 2-ethanedithiol (C2H6S2) has a molecular weight of 94.19 g/mol, a monoisotopic mass of 93.991 g/mol and an exact mass of 93.991 g/mol. It has a heavy atom count of 4, a topographical surface area of 2 A^2, and a complexity of 6. EDT has a hydrogen bond donor and acceptor count of 2 and 2 respectively.
EDT gas a boiling point of 146 deg C at 760 mm Hg and a melting point of -41.2 °C. It dissolves in benzene, acetone, ether, ethanol and oxygenated solvents, while it is sparingly soluble in alkali. EDT dissolves in water at 1.12X10+4 mg/L at 25 deg C (est).
1,2-ethanedithiol has an extrapolated vapor pressure of 5.61 mm Hg at 25 deg C. When heated, EDT decomposes to emit toxic fumes comprising of sulfur oxides. Its odor is mild at 31 ppb and it gets more noticeable at 5.6 ppm.


1,2-ethanedithiol can be synthesized by reacting an alkali metal hydrosulfide with an alkylene halide. However, this method does not yield a good amount of EDT due to the formation of by-products such as polymeric materials. The formation of these by-products could be reduced by conducting the reaction in an autoclave where the pressure is regulated to H 8. EDT can also be prepared through the decomposition of thiourea and the isothiuronium salt of ethylene bromide. This method yields slightly higher dithiol yields as indicated in the general formula where n is equal to or more than 3, for instance, 1,4-butanedithiol and 1,3-propanedithiol. However, this method also imposes significant constraints in the preparation of lower members of the dithiol series, such as 1,2-ethanedithiol. An additional method for the preparation of the compound entails the reaction between ethylene sulfide and H 8 in methanol, which yields approximately 49% of 1,2-ethanedithiol. However, this method also yields products with a relatively high molecular weight, which account for about 20% of the total products. There is a wide range of other methods that have been suggested for the synthesis of 1,2-ethanedithiol but they have been disqualified based on certain justifications.
The process highlighted below entails three major steps: 1) the generation of ethylene sulfide, 2) reaction of ethylene sulfide with hydrosulfide and 3) the liberation of 1,2-ethanedithiol through acid treatment. Z-mercaptoethy-lcarbonate is added to an alkaline solution in the portions highlighted above over a 30-minute period, the pH of the alkaline solution should be above 6.8, where the base is indicated with the general formula MOH, where M indicates an alkali-metal hydroxides such as potassium, lithium or sodium. The contents should also include 1-2 moles of the reacting ammonium hydrosulfide per mole of the alkyl 2-mercaptoethylcarbonate. Stir the reaction contents while maintaining the temperature at -100 C while adding the alkyl portions. The solution can be saturated with hydrogen sulfide by passing the gas through the reaction contents for about 2 hours. The contents should be stirred for a period of 10-20 hours or more while maintaining the temperature at 15300 C. The solution is cooled and reacted with an acid such as phosphoric, sulfuric or hydrochloric acids, and 1,2-ethanedithiol is separated from the mixture through conventional means such as extraction using a volatile solvent such as benzene or chloroform, or by distillation. This step is followed by the evaporation of the contents to remove the solvent. A combination of both processes could be more effective, where the dried product is taken through fractional distillation. This method involving ammonium hydrosulfide and ethyl Z-mercaptoethyl carbonate is highly preferred for the preparation of 1,2-ethanedithiol.


One should wash their hands thoroughly after contact with 1,2-ethanedithiol. It is not recommended to smoke, eat or drink while handling EDT. If ingested, one should contact a doctor immediately or the poison center. In the event of a fire, one should use appropriate apparatus to extinguish the fire. If the chemical comes into contact with one’s clothes or skin, they should take off the clothes and rinse their skin with plenty of water.

Hazard Statements

1,2-ethanedithiol is a flammable liquid. EDT is toxic when ingested and it may result in acute toxicity. It may cause acute dermal toxicity upon contact with the skin. EDT may result in serious eye irritation/damage and it may also cause acute toxicity upon inhalation.
Inhalation of EDT vapours may cause severe nausea or headaches.

Chemical Properties

Clear colorless solid


Metal-complexing agent. Reverses the inhibition by α-keto aldehydes on mitosis in E. coli.


Vapors cause severe headache and nausea.

Safety Profile

Poison by ingestion, intraperitoneal, and intravenous routes. When heated to decomposition it emits very toxic fumes of SOx. See also MERCAPTANS .

1,2-Ethanedithiol Preparation Products And Raw materials

Raw materials

Preparation Products

1,2-Ethanedithiol Suppliers

Global( 227)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 China 19953 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32651 55
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 24118 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254 CHINA 20229 58
career henan chemical co
+86-371-86658258 CHINA 19997 58
Kono Chem Co., Ltd
+86-132 8924 6953 CHINA 2164 58
Shanghai LanRun Chemical Co., Ltd. 021-69515658 ; 69515628
021-69515998 China 5966 50
Beijing HuaYangZhicheng Technology Co., Ltd. 13716033033
010-56276266 China 4670 50

View Lastest Price from 1,2-Ethanedithiol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-18 1,2-Ethanedithiol
US $1.00 / kg 1kg 98% 1000kg career henan chemical co

1,2-Ethanedithiol Spectrum

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