ChemicalBook >> CAS DataBase List >>Methylene Blue trihydrate

Methylene Blue trihydrate

CAS No.
7220-79-3
Chemical Name:
Methylene Blue trihydrate
Synonyms
METHYLENE BLUE HYDRATE;Methylene Blue, CP;METHYLTHIONINE CHLORIDE;Methylene Blue trihydratee;Methyltltioninium Chloride;Methylthioninium Chloride Trihydrate;SJ-09;CI 52015;CI NO 52015;ue trihydrate
CBNumber:
CB3748860
Molecular Formula:
C16H20ClN3OS
Molecular Weight:
337.87
MDL Number:
MFCD00150008
MOL File:
7220-79-3.mol
Last updated:2023-12-12 13:20:58

Methylene Blue trihydrate Properties

Melting point 190 °C (dec.)(lit.)
Density 0.98 g/mL at 25 °C
Flash point 14 °C
storage temp. no restrictions.
solubility Soluble in water, chloroform; sparingly soluble in ethanol
Colour Index 52015
form Solid
pka 2.6, 11.2(at 25℃)
color Green
Water Solubility 4 g/100 mL
λmax 668 nm, 609 nm
Merck 13,6085
Stability Stable. Incompatible with bases, reducing agents, strong oxidizing agents.
Biological Applications Diagnosis of tauopathy,Alzheimer’s disease (AD),Pick’s disease; treating prophylaxis; dental materials
InChIKey YAFGUSOAMIMROI-UHFFFAOYSA-M
CAS DataBase Reference 7220-79-3(CAS DataBase Reference)
FDA UNII T42P99266K
IARC 3 (Vol. 108) 2016
EPA Substance Registry System Methylene blue trihydrate (7220-79-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
Hazard Codes  Xn,F
Risk Statements  22-36/37/38-11
Safety Statements  26-36-24/25-16-7
RIDADR  UN 1170 3/PG 2
WGK Germany  3
RTECS  SP5740000
TSCA  Yes
HS Code  32129000

Methylene Blue trihydrate price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1.59270 Methylene blue (C.I. 52015) Reag. Ph Eur 7220-79-3 10g $52.1 2024-03-01 Buy
Sigma-Aldrich 6210-OP OmniPur Methylene Blue, Trihydrate - CAS 7220-79-3 - Calbiochem 7220-79-3 100g $165 2024-03-01 Buy
Sigma-Aldrich 1.59270 Methylene blue (C.I. 52015) Reag. Ph Eur 7220-79-3 100g $192 2024-03-01 Buy
Sigma-Aldrich 1.15943 Methylene blue (C.I.52015) for microscopy Certistain? 7220-79-3 100g $293 2023-06-20 Buy
Sigma-Aldrich 1.15943 Methylene blue (C.I.52015) for microscopy Certistain? 7220-79-3 25g $68.9 2023-01-07 Buy
Product number Packaging Price Buy
1.59270 10g $52.1 Buy
6210-OP 100g $165 Buy
1.59270 100g $192 Buy
1.15943 100g $293 Buy
1.15943 25g $68.9 Buy

Methylene Blue trihydrate Chemical Properties,Uses,Production

Chemical Properties

Methylene Blue trihydrate is a dark green crystalline powder that has a bronze-like luster. When dissolved in water or alcohol, it creates a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It can also inhibit guanylate cyclase and has been used to treat cyanide poisoning and lower levels of methemoglobin.

Uses

Methylene Blue trihydrate finds many uses in biology and chemistry. It acts as a GCS inhibitor, biological stain and redox indicator. It inhibits tau filament formation. Further, it is reported to bind to the M2 subtype of muscarinic receptors in rat cardiac myocytes and thus exhibit antimuscarinic effects on IK, ACh and ICa. It also inhibits endothelium-dependent relaxation of isolated blood vessels.

Application

Methylene blue is not an officially restricted drug. It is mainly used to control water mildew and small melon insects. It can replace malachite green. Methylene blue dissolved in water does little harm to fish. In addition, the drug has made achievements in many fields such as industry, medicine and skin care. Even the drug will be applied to more difficult cancer diseases. Methylene blue is more effective in the treatment of non advanced fish diseases. Methylene blue is an oxidant, which can oxidize nitrite into nitrate, inhibit and kill bacteria. However, it also has a certain impact on nitrifying bacteria, so some measures should be taken after use.
Methylene blue can be used in the manufacture of ink and lakes and the dyeing of biological and bacterial tissues. It can be used for dyeing cotton, hemp, silk fabrics, paper and bamboo and wood. It can also be mixed with crystal violet and yellow dextrin in the ratio of 78:13:9 to form alkaline magenta blue.

Preparation

Methylene blue is synthesized commercially by oxidation of N,N-dimethyl-phenylenediamine with sodium dichromate (Na2Cr2O7) in the presence of sodium thiosulfate (Na2S2O3), followed by further oxidation in the presence of N,N-dimethylaniline (NTP, 2008). Methylene blue hydrochloride is isolated by addition of 30% hydrochloric acid and of a saturated common salt solution to the dye solution; after filtration, the product is washed with a 2% common salt solution. Instead of sodium dichromate, manganese dioxide, and catalytic amounts of copper sulfate can be used for the oxidation (Berneth, 2008).
Methylene blue of high purity can be obtained by chloroform extraction of impurities from solutions of raw dye in borate buffer at pH 9.5–10, followed by acidification of the aqueous solution and isolation of the dye (Berneth, 2008).
IARC Monographs

General Description

Methylene blue trihydrate appears as odorless or almost odorless dark green crystals with bronze luster or dark green crystalline powder. pH (1% solution in water) 3 to 4.5. (NTP, 1992)

Air & Water Reactions

Hygroscopic. Water soluble. Gives a blue solution in water.

Reactivity Profile

Methylene Blue trihydrate is incompatible with strong oxidizing agents, caustics, alkali metal iodides and reducing agents. Also incompatible with dichromates. Methylene Blue trihydrate forms double salts with many inorganic salts. Is bleached reversibly by (zinc + hydrochloric acid) or sodium hydrosulfite. In aqueous solution, Methylene Blue trihydrate is decolorized by zinc dust and dilute sulfuric acid, but the color is restored upon exposure to air and more rapidly upon addition of ammonium hydroxide.

Fire Hazard

Flash point data for Methylene Blue trihydrate are not available; however, Methylene Blue trihydrate is probably combustible.

storage

Room temperature

Global( 452)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Guanlang Biotechnology Co,.LTD
+8619930503252 daisy@crovellbio.com China 5966 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2504 58
Shaanxi Haibo Biotechnology Co., Ltd
+86-02963020060 +86-18629295024 hibo06@xaltbio.com China 1000 58
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 14936 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9354 55
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293 sales@sdzschem.com China 2931 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Xiamen AmoyChem Co., Ltd
+86-592-6051114 +8618959220845 sales@amoychem.com China 6387 58

Related articles

View Lastest Price from Methylene Blue trihydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Methylene Blue trihydrate pictures 2023-12-25 Methylene Blue trihydrate
7220-79-3
US $0.00 / kg 1kg 99% 1000000 Hebei Jingbo New Material Technology Co., Ltd
Methylene Blue trihydrate pictures 2023-11-08 Methylene Blue trihydrate
7220-79-3
US $0.00 / kg 1kg 99% 2000ton Shaanxi Haibo Biotechnology Co., Ltd
Methylene Blue Trihydrate pictures 2023-09-08 Methylene Blue Trihydrate
7220-79-3
US $5.00-2.00 / KG 1KG 99% 10000kg Hebei Guanlang Biotechnology Co,.LTD
Methylene Blue, high purity, biological stain METHYLENE BLUE GR (C.I.No 52015 ) Methylene blue tvihydrate Methylene Blue trihydrate, pure, 95% METHYLENE BLUE SOLUTION 0.05% AQUEOUS 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride methylthionium chloride Methylene Blue (750 mg) R2A PETRI 90MM DOUBLE-WRAP (6X20) Methylene Blue, Trihydrate, Certified Methylene Blue Solution, 1.4%(w/v) in ethanol 3,7-bis(dimethylamino)phenazathionium Chloride Trihydrate CI NO 52015 BASIC BLUE 9 HYDRATE 3,7-bis(dimethylamino)phenothiazin-5-iumchloridetrihydrate c.i.basicblue9,trihydrate Methylene Blue trihydrate, pure, 95% 100GR Methylene blue stain for DNA Methylene Blue Aqueous Solution phenothiazin-5-ium,3,7-bis(dimethylamino)-,chloride,trihydrate Basic Blue 9 trihydrate C.I. 52015 trihydrate MethyleneBluepract Methylene Blue BB METHYLENE BLUE, CERTIFIED (C.I. 52015) METHYLENE BLUE, CERTIFIED MethyleneBlueC.I.52015 MethyleneBlue1%AlcoholicSolution 3,7-bis(Dimethylamino)phenazathionium chloride, Basic Blue 9, Tetramethylthionine chloride (7-Dimethylaminophenothiazin-3-ylidene)-dimethylazanium chloride trihydrate Methylene Blue trihydrate,95%,pure Methylene Blue trihydrateBasic Blue 9 trihydrateC.I. 52015 trihydrate Tetramethylthionine chloride C.I. 52015 trihydrate Methylene blue trihydrate [for biological staining] Methylene Blue (250 mg) Methylene Blue (250 mg)H0D1631.000mg/mg(dr) Methylene Blue trihy METHYLTHIONINE CHLORIDE TRIHYDRATE METHYLENE BLUE, CHLORIDE, TRIHYDRATE METHYLENE BLUE CHLORIDE METHYLENE BLUE INDICATOR METHYLENE BLUE TRIHYDRATE METHYLENE BLUE TS METHYLENE BLUE 2-3HYDRATE CI 52015 Methylene blue Solution, 100X 1 Solution Methylene Blue Chloride Trihydate Methylene Blue trihydrate, for bio Methylene Blue Trihydrate Standard Methylene Blue trihydrate USP/EP/BP Dye Methylene Blue trihydrate ue trihydrate Methylene blue indicator solution Methylene Blue trihydrate solution OmniPur Methylene Blue, Trihydrate - CAS 7220-79-3 - Calbiochem METHYLENE BLUE SOLUTION, 0.05% AQUEOUSMETHYLENE BLUE SOLUTION, 0.05% AQUEOUSMETHYLENE BLUE SOLUTION, 0.05% AQUEOUS METHYLENE BLUEMETHYLENE BLUEMETHYLENE BLUE Methylene blue, Dye content