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Atenolol

Pharmacological Affects Chemical Property Uses
Atenolol
Atenolol structure
CAS No.
29122-68-7
Chemical Name:
Atenolol
Synonyms
Unilo;Altol;Ateni;noten;Seles;Xaten;Alinor;Atelol;Atenet;Atenil
CBNumber:
CB3753116
Molecular Formula:
C14H22N2O3
Formula Weight:
266.34
MOL File:
29122-68-7.mol

Atenolol Properties

Melting point:
154°C
Boiling point:
409.54°C (rough estimate)
Density 
1.0807 (rough estimate)
refractive index 
1.5110 (estimate)
Flash point:
2℃
storage temp. 
Store at RT
solubility 
H2O: 0.3 mg/mL
form 
powder
pka
9.6(at 25℃)
color 
white to off-white
Merck 
14,859
InChIKey
METKIMKYRPQLGS-UHFFFAOYSA-N
CAS DataBase Reference
29122-68-7(CAS DataBase Reference)
NIST Chemistry Reference
Atenolol(29122-68-7)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,F
Risk Statements  22-36/37/38-20/21/22-36-11
Safety Statements  22-24/25-36-26-36/37-16
RIDADR  UN 1648 3 / PGII
WGK Germany  2
RTECS  AC3600000
HazardClass  IRRITANT
HS Code  29242995
Hazardous Substances Data 29122-68-7(Hazardous Substances Data)
Toxicity LD50 in mice, rats (mg/kg): 2000, 3000 orally; 98.7, 59.24 i.v. (Fitzgerald)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P235 Store in a well-ventilated place. Keep cool.

Atenolol price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 74827 Atenolol analytical reference material 29122-68-7 100mg $62.3 2018-11-20 Buy
Sigma-Aldrich 1044403 Atenolol United States Pharmacopeia (USP) Reference Standard 29122-68-7 200mg $352.8 2018-11-20 Buy
Alfa Aesar J61199 (±)-Atenolol 29122-68-7 1g $56.3 2018-11-13 Buy
Cayman Chemical 17250 (R,S)-Atenolol ≥98% 29122-68-7 5g $81 2018-11-13 Buy
Cayman Chemical 17250 (R,S)-Atenolol ≥98% 29122-68-7 1g $25 2018-11-13 Buy

Atenolol Chemical Properties,Uses,Production

Pharmacological Affects

Atenolol ,also known as atenolol, Aten Yue Er, tamoxifen, downhill Ling blood pressure, Tenormin, blood pressure Ling, is a long-acting cardioselective β1-adrenergic blockers, without intrinsic sympathomimetic activity or membrane stability.The atenolol,s retardation for β1 adrenaline receptors is similar with metoprolol, propranolol and nadolol , which is 1/6 times for pindolol and timolol. But, it does not inhibit the effect of the isoproterenol bronchodilator.When administered in small doses, it does not like non-selective β-adrenergic blockers as aggravated hypoglycemia induced hypertensive crisis, peripheral circulatory impairment or patients with obstructive airways disease worsening airway function and so on. However, When administered in large doses, atenolol also can decrease asthma or chronic obstructive pulmonary disease, airway function. Atenolol, as a long-term treatment of hypertension, also were reported for affecting airway function. Thus, despite atenolol heart selection, chronic obstructive pulmonary disease patients can only use small doses, but also should be given a sufficient amount of β1-adrenergic receptor agonists.
Oral F is 46%~60%, Tmax about 2~4 h, Mainly unchanged since the urine excretion, T1/2 of 6~7 h. Hemodialysis can clear the goods. Rapidly absorbed from the gastrointestinal tract, but not exclusively.The rest of the body is excreted in the stool. Food can reduce the F, fasting and after meals AUC decreased by 20%. Distribution of the central nervous system is relatively few. The ratio of brain tissue to blood concentration was 0.1:1. Easy to achieve in the placenta and the maternal plasma concentrations of same. PPB is less than 5%, Vd is 50~75 L. Atenolol is not metabolized by the liver, most of the drug is excreted from the body in urine, renal insufficiency in patients with T1/2 was significantly prolonged. Patients with renal failure range of T1/2 was 10~28 h, or even up to 100 h. Results at 24 h after, the discharge from the urine of the drug can be reduced by 29%. The T1/2 of patients with hyperthyroidism was significantly shortened, 4.2h.
The above information is edited by the chemicalbook of Kui Ming.

Chemical Property

White powder. Melting point (146-148 ℃). Soluble in alcohol, slightly soluble in water, chloroform, Hardly soluble in ethyl ether, slightly smelly.

Uses

β-blockers. Clinical application in the treatment of hypertension, angina and arrhythmia.

Chemical Properties

White or almost white powder.

Uses

Selective b1 adrenergic receptor agonist, anti-hypertensive, anti-anginal, anti-arrhythmic

Definition

ChEBI: An ethanolamine compound having a (4-carbamoylmethylphenoxy)methyl group at the 1-position and an N-isopropyl substituent.

brand name

Tenormin (AstraZeneca).

Biological Activity

Cardioselective β -adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic.

Atenolol Preparation Products And Raw materials

Raw materials

Preparation Products


Atenolol Suppliers

Global( 231)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3217 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2548 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 552 55
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20243 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8430 58
Jinan Tenglong Chemical Co.,Ltd
Whatsapp:+8615563263311 Skype:live:smions7080
smions7080@gmail.com CHINA 770 58
Hebei Ruishun Trade Co.,LTD
17052563120
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career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19997 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76

View Lastest Price from Atenolol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 Atenolol
29122-68-7
US $1.00 / KG 1G 98% 100KG career henan chemical co
2018-03-28 Atenolol
C14H22N2O3
US $10.00 / KG 10KG 99% 10MT Hubei XinRunde Chemical Co., Ltd.
2018-11-21 Atenolol CAS 29122-68-7
29122-68-7
US $1.00 / G 100G 99.9% 50000 tons Hebei Ruishun Trade Co.,Ltd

Atenolol Spectrum


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