ChemicalBook >> CAS DataBase List >>PROTOVERATRINE A

PROTOVERATRINE A

PROTOVERATRINE A structure

CAS No.: 143-57-7

Chemical Name:: PROTOVERATRINE A

Synonyms: Nsc7526;protalba;Pro-AMid;Puroverin;Puroverine;protoveratrin;PROTOVERATRINE A;Protofecaterine a;PROTOVERATRINE A (RG);HYTGGNIMZXFORS-MGYKWWNKSA-N

CBNumber:: CB3753611

Molecular Formula:: C41H63NO14

Molecular Weight:: 793.94

MDL Number:: MFCD00135586

MOL File:: 143-57-7.mol

Last updated:2023-05-15 10:43:22

PROTOVERATRINE A Properties

Melting point	267-269°C
alpha	D25 -40.5° (pyridine); D25 -10.5° (chloroform)
Boiling point	747.91°C (rough estimate)
Density	1.36±0.1 g/cm3 (20 ºC 760 Torr)
refractive index	1.6220 (estimate)
storage temp.	2-8°C
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	powder
pka	10.74±0.70(Predicted)
color	White
FDA UNII	XP343X1HJU

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H300+H310+H330
Precautionary statements	P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310
Hazard Codes	T+
Risk Statements	26/27/28
Safety Statements	22-36/37/39-45
RIDADR	UN 1544 6.1/PG 1
WGK Germany	3
RTECS	FL5750100
HazardClass	6.1(a)
PackingGroup	I
Toxicity	LD50 s.c. in male mice: 0.29 mg/kg (Tanaka)

PROTOVERATRINE A Chemical Properties,Uses,Production

Description

A further alkaloid isolated from Veratrum album, this base yields colourless crystals from EtOH. It is laevorotatory with [α]²⁷_D - 44.1° (pyridine) or - 12.1° (CHC13). Like the preceding base, it dissolves in H2S04 to give a blue colour. The complex with maleic acid has been prepared as colourless crystals, m.p. 241.5°C; [α]²⁰_D - 37.6°. On alkaline hydrolysis, the alkaloid furnishes protoverine, two moles of acetic acid, one mole of (-)-methylbutyric acid and one mole of (+)-2-hydroxy-2-methylbutyric acid.

Uses

Protoveratrine A is a pharmacological agent which displays neuroprotective effects in ischemic stroke.

Definition

ChEBI: Protoveratrine A is an alkaloid.

brand name

Protalba (Marion Merrell Dow).

target

Calcium Channel | Potassium Channel

References

Stoll, Seebeck., Helv. Chim. Acta, 36,718 (1953)

PROTOVERATRINE A Preparation Products And Raw materials

Raw materials

Preparation Products

143-57-7(PROTOVERATRINE A)Related Search:

3-PIPERIDINE ETHANOL ISOPROPYL (S)-(-)-LACTATE TETRAHYDROFURFURYL PROPIONATE TETRAHYDROFURFURYL BUTYRATE 2,4-Dimethylpiperidine

myralact CETYL LACTATE cis-2,6-Dimethylpiperidine PROTOVERATRINE,PROTOVERATRINE A AND B,PROTOVERATRINE A+B PROTOVERATRINE A

4-CYCLOHEXYL-BUTYLAMINE LACTIC ACID ISOAMYL ESTER PROTOVERATRINE B (RG),PROTOVERATRINE B (3R,5R)-2,6-Dimethyl-3,5-heptanediol TRANS-DECAHYDROISOQUINOLINE

4-PIPERIDIN-1-YL-BUTAN-1-OL CIS-1,2-CYCLOHEXANEDIMETHANOL (S)-Butyl 2-hydroxybutanoate

1of4

PROTOVERATRINE A 6,7-diacetate3-((+)-2-hydroxy-2-methylbutyrate)15-((-)-2-methylbutyrate) protalba protoveratrin [3beta(S),4alpha,6alpha,7alpha,15alpha(R),16beta]-4,9-epoxycevane-3,4,6,7,14,15,16,20-octol 6,7-diacetate 3-(2-hydroxy-2-methylbutyrate) 15-(2-methylbutyrate) 4α,9-Epoxycevane-3β,4,6α,7α,14,15α,16β,20-octol 6,7-diacetate 3-[(S)-2-hydroxy-2-methylbutanoate]15-[(R)-2-methylbutanoate] Puroverine Cevane-3,4,6,7,14,15,16,20-octol, 4,9-epoxy-, 6,7-diacetate 3-(2-hydroxy-2-methylbutanoate) 15-(2-methylbutanoate), [3.beta.(S),4.alpha.,6.alpha.,7.alpha.,15.alpha.(R),16.beta.]- Cevane-3.beta.,4.beta.,6.alpha.,7.alpha.,14,15.alpha.,16.beta.,20-octol, 4,9-epoxy-, 6,7-diacetate 3-((+)-2-hydroxy-2-methylbutyrate) 15-((-)-2-methylbutyrate) Cevane-3.beta.,4.beta.,6.alpha.,7.alpha.,14,15.alpha.,16.beta.,20-octol, 4,9-epoxy-, 6,7-diacetate, 3-((+)-2-hydroxy-2-methylbutyrate) 15-((-)-2-methylbutyrate) Nsc7526 Protofecaterine a PROTOPINE HCL(FUMARINE HCL)(RG)(CALL) Pro-AMid Puroverin PROTOVERATRINE A (RG) HYTGGNIMZXFORS-MGYKWWNKSA-N Cevane-3,4,6,7,14,15,16,20-octol, 4,9-epoxy-, 6,7-diacetate 3-[(2S)-2-hydroxy-2-methylbutanoate] 15-[(2R)-2-methylbutanoate], (3β,4α,6α,7α,15α,16β)- 143-57-7 C41H63NO14 Miscellaneous Natural Products