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DELTORPHIN II

DELTORPHIN II structure

CAS No.: 122752-16-3

Chemical Name:: DELTORPHIN II

Synonyms: DADELT II;Declostatin;DELTORPHIN B;Deltorphin 2;DELTORPHIN II;Deltorphin 2(TFA);ala(2)-deltorphini;DELTORPHIN 2?, >98%;Y-{d-Ala}-FEVVG-NH2;[D-ALA2]-DELTORPHIN II

CBNumber:: CB3759219

Molecular Formula:: C38H54N8O10

Molecular Weight:: 782.88

MDL Number:: MFCD00080072

MOL File:: 122752-16-3.mol

Last updated:2023-10-10 18:06:03

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DELTORPHIN II Properties

Boiling point	1256.2±65.0 °C(Predicted)
Density	1.272±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble to 1 mg/ml in 10% acetonitrile
form	solid
pka	4.43±0.10(Predicted)
color	White
Water Solubility	Soluble to 1 mg/ml in water

SAFETY

Risk and Safety Statements

WGK Germany	3

DELTORPHIN II price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T0675	[D-Ala2]-Deltorphin II ≥97% (HPLC)	122752-16-3	1mg	$137	2024-03-01	Buy
Tocris	1180	[D-Ala2]-Deltorphin II	122752-16-3	1	$101	2021-12-16	Buy
Usbiological	D2735-01B	Deltorphin II	122752-16-3	1mg	$531	2021-12-16	Buy
TRC	D228838	[D-Ala2]-Deltorphin II	122752-16-3	10mg	$505	2021-12-16	Buy
ApexBio Technology	B5072	[D-Ala2]-Deltorphin II	122752-16-3	10mg	$520	2021-12-16	Buy

Product number	Packaging	Price	Buy
T0675	1mg	$137	Buy
1180	1	$101	Buy
D2735-01B	1mg	$531	Buy
D228838	10mg	$505	Buy
B5072	10mg	$520	Buy

DELTORPHIN II Chemical Properties,Uses,Production

Uses

[D-Ala2]-Deltorphin II (cas# 122752-16-3) is a useful research chemical.Deltorphin II is one of the naturally occurring peptides with high affinity and selectivity for δ-??opioid binding sites. Deltorphin II showed even higher affinity for δ-??opioid receptors than previously characterized deltorphins. Also, Deltorphin II were identified as new transport substrates of OATP-??A

Definition

ChEBI: Deltorphin B is a peptide.

Biological Activity

[d-ala2]-deltorphin ii (dadelt ii) is a natural agonist of δ opioid receptor with ki or ic50 value of 0.41 nm [1, 2].opioid receptors are most abundant in the central nervous system, but are also localized in many peripheral tissues in mammalian organisms. there are three types of opioid receptors that are well-defined; the μ, δ and κ receptors [2].[d-pen2, d-pen5]enkephalin (dpdpe) is a second highly selective agonist of δ [3]. treatment with dpdpe at 1 m for as short as 3 min significantly diminished the inhibition of the opioid receptor in ng108-15 cells to cyclic amp production. that means neuronal delta opioid receptor underwent acute desensitization. this desensitization was temporally parallel to the phosphorylation of delta opioid receptor 3 min. after agonist stimulation [4].i.c.v. administration of dadelt ii from 0.38-12.78 nm resulted in a dose- and time-related antinociception. 10 min after the administration of dadelt ii, the maximal antinociceptive response was seen. until 60 min after the administration of dadelt ii, effects were detected. these antinociceptive effects of i.c.v. dadelt ii were antagonized by the selective δ antagonist, ici 174,864 [3]. after supraspinal and spinal administration in rats intracerebroventricularly, dadelt ii at 0.2, 1, 10 μg/rat in a dose-related fashion inhibited diarrhea and colonic bead expulsion but did not show any effect on the rate of small intestine transit. spinal administration of dadelt ii at the same dose produced similar results. naltrindole is a selective antagonist of the δ opioid receptor. subcutaneous pretreatment with naltrindole at 1 and 10 mg/kg antagonized effects of dadelt ii partially and completely, respectively [1].

Biochem/physiol Actions

Selective δ2 opioid receptor agonist

storage

Store at -20°C

References

[1]. broccardo m, improta g. antidiarrheal and colonic antipropulsive effects of spinal and supraspinal administration of the natural δ opioid receptor agonist,[d-ala2] deltorphin ii, in the rat. european journal of pharmacology, 1992, 218(1): 69-73.
[2]. janecka a, fichna j, janecki t. opioid receptors and their ligands. current topics in medicinal chemistry, 2004, 4(1): 1-17.
[3]. jiang q, mosberg hi, porreca f. antinociceptive effects of [d-ala2] deltorphin ii, a highly selective δ agonist in vivo. life sciences, 1990, 47(11): pl43-pl47.
[4]. cai y, zhang y, wu y, et al. δ opioid receptor in neuronal cells undergoes acute and homologous desensitization. biochemical and biophysical research communications, 1996, 219(2): 342-347.

DELTORPHIN II Preparation Products And Raw materials

Raw materials

Preparation Products

DELTORPHIN II Suppliers

Global( 104)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	999	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
Hangzhou Go Top Peptide Biotech	0571-88211921	sales1@gotopbio.com	CHINA	2609	58
Chengdu Youngshe Chemical Co., Ltd.	+8618108235634	Cecilia@youngshechem.com	China	2345	58
Nanjing Doge Biomedical Technology Co., Ltd	+86-25-58227606 +86-15305155328	sales@dogechemical.com	China	4128	58

Supplier	Advantage
Hebei Yanxi Chemical Co., Ltd.	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Shenzhen Nexconn Pharmatechs Ltd	58
Cellmano Biotech Limited	58
Career Henan Chemica Co	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Zhejiang J&C Biological Technology Co.,Limited	58
Hangzhou Go Top Peptide Biotech	58
Chengdu Youngshe Chemical Co., Ltd.	58
Nanjing Doge Biomedical Technology Co., Ltd	58

View Lastest Price from DELTORPHIN II manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2023-11-27	DELTORPHIN II 122752-16-3	US $0.00 / GRAM	1GRAM	99%	20 TONS	Wuhan Senwayer Century Chemical Co.,Ltd
	2023-10-10	DELTORPHIN II 122752-16-3	US $0.00 / kg	1kg	0.99	20tons	Hebei Yanxi Chemical Co., Ltd.

DELTORPHIN II
122752-16-3
US $0.00 / GRAM
99%
Wuhan Senwayer Century Chemical Co.,Ltd

DELTORPHIN II
122752-16-3
US $0.00 / kg
0.99
Hebei Yanxi Chemical Co., Ltd.

122752-16-3(DELTORPHIN II)Related Search:

Bismuth hydroxide nitrate oxide, BiO5.1 DELTORPHIN I DELTORPHIN deltorphin II, Ile(5,6)- Deltorphin II [D-Ala2]

Deltorphin II (Deltorphin B) DELTORPHIN II, (2-D-ALA), [TYROSYL-3,5-3H]- DELTORPHIN II

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M.W. 782.89 C38H54N8O10 [D-Ala2,Glu4]deltorphin C [D-Ala2,Glu4]Deltorphin II DADELT II H-TYR-D-ALA-PHE-GLU-VAL-VAL-GLY-NH2 DELTORPHIN B DELTORPHIN II [D-ALA2]-DELTORPHIN II TYR-D-ALA-PHE-GLU-VAL-VAL-GLY AMIDE TYR-D-ALA-PHE-GLU-VAL-VAL-GLY-NH2 ala(2)-deltorphini deltorphin II, Ala(2)- Deltorphin 2 Deltorphin 2(TFA) Deltorphin 2,[D-Ala2]-Deltorphin II, >98% DELTORPHIN 2?, >98% Glycinamide, L-tyrosyl-D-alanyl-L-phenylalanyl-L-α-glutamyl-L-valyl-L-valyl- D-Ala2]-Deltorphin II >=97% (HPLC) Declostatin Y-{d-Ala}-FEVVG-NH2 Glycinamide, L-tyrosyl-D-alanyl-L-phenylalanyl-L-α-glutamyl-L-valyl-L-valyl- 122752-16-3 C38H54N8O10 Biochemicals and Reagents Amino Acids and Peptides BioChemical Peptides Opioid Peptides Other Opioid Peptides Opioid receptor and opioid-like receptor