6-FLUORO-DL-TRYPTOPHAN
- CAS No.
- 7730-20-3
- Chemical Name:
- 6-FLUORO-DL-TRYPTOPHAN
- Synonyms
- H-Trp(6-F)-OH;H-DL-Trp(6-F)-OH;6-FLUOROTRYPTOPHAN;H-6-FLUORO-DL-TRP-OH;DL-6-FLUOROTRYPTOPHAN;6-fluoro-dl-tryptopha;Tryptophan, 6-fluoro-;6-FLUORO-DL-TRYPTOPHAN;6-Fluoro-DL-tryptophan,97%;6-FLUORO-DL-TRYPTOPHAN USP/EP/BP
- CBNumber:
- CB3764974
- Molecular Formula:
- C11H11FN2O2
- Molecular Weight:
- 222.22
- MDL Number:
- MFCD00005653
- MOL File:
- 7730-20-3.mol
- MSDS File:
- SDS
| Melting point | 280-285 °C (dec.)(lit.) |
|---|---|
| Boiling point | 450.7±45.0 °C(Predicted) |
| Density | 1.2556 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | Aqueous Base (Slightly), Methanol (Slightly, Heated), Water (Slightly) |
| form | crystalline |
| pka | 2.22±0.10(Predicted) |
| color | Almost white to beige |
| CAS DataBase Reference | 7730-20-3(CAS DataBase Reference) |
| FDA UNII | 3I7LZ8M32B |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P271-P261-P280 | |||||||||
| Hazard Codes | T | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YN6850000 | |||||||||
| Hazard Note | Toxic | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
6-FLUORO-DL-TRYPTOPHAN price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17643 | 6-fluoro-DL-Tryptophan ≥95% | 7730-20-3 | 50mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 17643 | 6-fluoro-DL-Tryptophan ≥95% | 7730-20-3 | 100mg | $78 | 2024-03-01 | Buy |
| Cayman Chemical | 17643 | 6-fluoro-DL-Tryptophan ≥95% | 7730-20-3 | 250mg | $151 | 2024-03-01 | Buy |
| Cayman Chemical | 17643 | 6-fluoro-DL-Tryptophan ≥95% | 7730-20-3 | 500mg | $231 | 2024-03-01 | Buy |
| TRC | F401785 | 6-Fluoro-DL-Tryptophan | 7730-20-3 | 250mg | $110 | 2021-12-16 | Buy |
6-FLUORO-DL-TRYPTOPHAN Chemical Properties,Uses,Production
Chemical Properties
almost white to beige powder
Definition
ChEBI: 6-Fluoro-DL-tryptophan is an indolyl carboxylic acid.
Biological Activity
6-fluoro-dl-tryptophan is a serotonin (5-ht) synthesis inhibitor.serotonin or 5-hydroxytryptamine (5-ht), a monoamine neurotransmitter, is biochemically derived from tryptophan. serotonin is primarily present in the gastrointestinal tract, blood platelets, and the central nervous system of animals. serotonin is considered to be a contributor to feelings of well-being and happiness.
in vitro
the potential competition was investigated between l-tryptophan (trp) and 6-fluoro-dl-tryptophan (6-f-trp). in equilibrium dialysis experiments, albumin bound about 80% of trp and 50% of 6-f-trp. competitive inhibition was assessed as the decrease in the apparent ka of trp in the presence of 6-f-trp, with no modification of the n value [1].
in vivo
rats werer administered 6-fluoro-dl-tryptophan (6f-trp) and its neurochemical effects on central catechole and indole were evaluated. results showed that neither norepinephrine nor dopamine and its major metabolites were affected by 6f-trp. with regard to serotonin (5-ht), 6f-trp could induce a transient depletion in all the studied brain areas, with a maximum of about 60-65% obtained between 1 and 3 hr. after 6 hr, 5-ht levels returned to control values. in addition, the 5-hydroxyindolacetic acid (5-hiaa) level was also reduced 3 hr after 6f-trp administration. a large dose-dependent increase in tryptophan was seen in the four brain areas, mainly due to an inhibition of tryptophan incorporation into protein, as demonstrated by experiments with mouse neuroblastoma cells [2].
References
[1] chanut, e. ,zini, r.,trouvin, j.h., et al. albumin binding and brain uptake of 6-fluoro-dl-tryptophan: competition with l-tryptophan. biochemical pharmacology 44(10), 2082-2085 (1992).
[2] chanut, e. ,trouvin, j.h.,bondoux, d., et al. metabolism of 6-fluoro-dl-tryptophan and its specific effects on the rat brain serotoninergic pathway. biochemical pharmacology 45(5), 1049-1057 (1992).
6-FLUORO-DL-TRYPTOPHAN Preparation Products And Raw materials
Raw materials
Preparation Products
6-FLUORO-DL-TRYPTOPHAN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10828 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4022 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
View Lastest Price from 6-FLUORO-DL-TRYPTOPHAN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-13 | 6-FLUORO-DL-TRYPTOPHAN
7730-20-3
|
US $1.00 / KG | 1KG | 98%-99.9% | 200kg | Career Henan Chemical Co |
-
- 6-FLUORO-DL-TRYPTOPHAN
7730-20-3
- US $1.00 / KG
- 98%-99.9%
- Career Henan Chemical Co
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