2'-Hydroxychalcone
- CAS No.
- 1214-47-7
- Chemical Name:
- 2'-Hydroxychalcone
- Synonyms
- 2-HYDROXYCHALC;O-CINNAMOYLPHENOL;6'-Hydroxychalcone;2'-HYDROXYCHALCONE;2'-hydroxychalcone;HYDROXYCHALCONE, 2'-;2'-HYDROXYCHALCONE 98%;2-HYDROXYBENZALACETOPHENONE;2-Hydroxyphenylstyryl ketone;2'-HYDROXYCHALCONE 1214-47-7
- CBNumber:
- CB3771305
- Molecular Formula:
- C15H12O2
- Molecular Weight:
- 224.25
- MDL Number:
- MFCD00016441
- MOL File:
- 1214-47-7.mol
- MSDS File:
- SDS
| Melting point | 86-88 °C(lit.) |
|---|---|
| Boiling point | 396.6±42.0 °C(Predicted) |
| Density | 1.191±0.06 g/cm3 (20 ºC 760 Torr) |
| storage temp. | Store below +30°C. |
| pka | 7.77±0.30(Predicted) |
| BRN | 976324 |
| LogP | 4.000 (est) |
| CAS DataBase Reference | 1214-47-7(CAS DataBase Reference) |
| FDA UNII | VY06DZ94OC |
| EPA Substance Registry System | 2-Propen-1-one, 1-(2-hydroxyphenyl)-3-phenyl- (1214-47-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UD5579400 | |||||||||
| F | 8 | |||||||||
| Autoignition Temperature | 280 °C | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29145090 | |||||||||
| Toxicity | mammal (species unspecified),LD50,unreported,620mg/kg (620mg/kg),Pharmaceutical Chemistry Journal Vol. 20, Pg. 406, 1986. | |||||||||
| NFPA 704 |
|
2'-Hydroxychalcone price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.14776 | 1-(2-Hydroxyphenyl)-3-phenyl-2-propenone for synthesis | 1214-47-7 | 25g | $69.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | S449725 | 2'-HYDROXYCHALCONE Aldrich | 1214-47-7 | 250mg | $179 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.14776 | 1-(2-Hydroxyphenyl)-3-phenyl-2-propenone for synthesis | 1214-47-7 | 100g | $216 | 2024-03-01 | Buy |
| TCI Chemical | H0385 | 2'-Hydroxychalcone >98.0%(HPLC) | 1214-47-7 | 25g | $68 | 2021-12-16 | Buy |
| Alfa Aesar | L13937 | 2'-Hydroxychalcone, 98+% | 1214-47-7 | 5g | $32.8 | 2024-03-01 | Buy |
2'-Hydroxychalcone Chemical Properties,Uses,Production
Chemical Properties
Yellow needle-like crystals (ethanol). Melting point 88-89°C.
Uses
2'-Hydroxychalcone can be used as intermediates in drug synthesis, such as the preparation of flavonol compounds. Flavonols are widely distributed in nature as secondary metabolites in living organisms, and they have a wide variety of physiological activities, mainly in the cardiovascular system, antiviral, anti-inflammatory and antitumor effects.
Definition
ChEBI: 2'-hydroxychalcone is a member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 2'. It has a role as an anti-inflammatory agent. It is a member of phenols and a member of chalcones. It derives from a trans-chalcone.
Preparation
Synthesis of 2'-hydroxychalcone: add 30 ml of 20% (V/V) ethanol and (11.06 mmol) sodium hydroxide in a 50 mL single mouth flask, stir for 0.5 h at room temperature and then add substituted 2-Hydroxyacetophenone (1.66 mmol) and benzaldehyde (1.66 mmol), stir for 18 h at room temperature, TLC monitoring until the new point produces raw material point no longer changes, stop the reaction Then the reaction was poured into water, stirred while adjusting the pH value to acidic with 6 mol/L hydrochloric acid, the reaction was filtered, the filter cake was obtained, rinsed twice with pure water, and 2'-hydroxychalcone was obtained by silica gel column chromatography [V(petroleum ether):V(ethyl acetate) = 5:1] in 85% yield.
2'-Hydroxychalcone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7845 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| AB PharmaTech,LLC | 323-480-4688 | United States | 989 | 55 | |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2169 | 58 |
View Lastest Price from 2'-Hydroxychalcone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-01-08 | 2'-Hydroxychalcone
1214-47-7
|
US $1.00 / g | 1g | 99% | 500tons | Wuhan Boyuan Import & Export Co., LTD | |
 |
2024-01-02 | 2'-HYDROXYCHALCONE
1214-47-7
|
US $200.00-1.00 / KG | 1KG | 99%, 99.5% Sublimated | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2024-01-02 | 2'-Hydroxychalcone
1214-47-7
|
US $85.00-850.00 / kg | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd |
-
- 2'-Hydroxychalcone
1214-47-7
- US $1.00 / g
- 99%
- Wuhan Boyuan Import & Export Co., LTD
-
- 2'-HYDROXYCHALCONE
1214-47-7
- US $200.00-1.00 / KG
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 2'-Hydroxychalcone
1214-47-7
- US $85.00-850.00 / kg
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd