TOMATIDINE
- CAS No.
- 77-59-8
- Chemical Name:
- TOMATIDINE
- Synonyms
- Tomatidin;omatidine;TOMATADINE;TOMATIDINE;NSC 226903;TOMATIDINE(RG);Spirosolan-3-ol;Tomatidine, >98%;high qualtiy Tomatidine;5alpha-Tomatidan-3beta-ol
- CBNumber:
- CB3774922
- Molecular Formula:
- C27H45NO2
- Molecular Weight:
- 415.65
- MDL Number:
- MFCD00075644
- MOL File:
- 77-59-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Tomatidine | 301066 | 10mg | $490 |
| Tomatidine | orb594522 | 100mg | $778.6 |
| TOMATIDINE 95.00% | PXT0015864 | 10MG | $782.23 |
| Tomatidine >98.0% | CS-5821 | 25mg | $60 |
| Tomatidine >98.0% | CS-5821 | 50mg | $96 |
| More product size | |||
| Melting point | 210.5℃ |
|---|---|
| alpha | D25 +8° (chloroform) |
| Boiling point | 534.2°C (rough estimate) |
| Density | 1.0048 (rough estimate) |
| refractive index | 1.6840 (estimate) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 2.86 mg/mL (6.88 mM);Water : < 0.1 mg/mL (insoluble) |
| pka | 15.14±0.70(Predicted) |
| form | Solid |
| color | White to off-white |
| LogP | 6.150 (est) |
| FDA UNII | 2B73S48786 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
| Risk Statements | 23/25 |
| Safety Statements | 1-45 |
| RIDADR | 1544 |
TOMATIDINE price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 301066 | Tomatidine | 77-59-8 | 10mg | $490 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb594522 | Tomatidine | 77-59-8 | 100mg | $778.6 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PXT0015864 | TOMATIDINE 95.00% | 77-59-8 | 10MG | $782.23 | 2021-12-16 | Buy |
| ChemScene | CS-5821 | Tomatidine >98.0% | 77-59-8 | 25mg | $60 | 2021-12-16 | Buy |
| ChemScene | CS-5821 | Tomatidine >98.0% | 77-59-8 | 50mg | $96 | 2021-12-16 | Buy |
TOMATIDINE Chemical Properties,Uses,Production
Definition
Tomatidine is the aglycone derivative of tomatine. Tomatidine belongs to the chemical family known as Spirosolanes and Derivatives. These are steroidal alkaloids whose structure contains a spirosolane skeleton. Tomatine (the glycosylated form of tomatidine) is a mildly toxic glycoalkaloid or glycospirosolane found in the stems and leaves of tomato plants as well as in the fruit of unripened (green) tomatoes (up to 500 mg/kg).
Pharmaceutical Properties
Red, ripe tomatoes have somewhat reduced amounts of tomatine and tomatidine. Both tomatine and tomatidine possess antimicrobial, antifungal and antiviral properties. Tomatidine has been shown to exhibit anti-virulence activity against normal strains of Staphylococcus aureus as well as the ability to potentiate the effect of aminoglycoside antibiotics. Recent studies have shown that tomatidine stimulates mTORC1 signaling and anabolism, leading to accumulation of protein and mitochondria, and ultimately, cell growth. Furthermore, in mice, tomatidine has been shown to increase skeletal muscle mTORC1 signaling, reduce skeletal muscle atrophy, enhance recovery from skeletal muscle atrophy, stimulate skeletal muscle hypertrophy, and increase strength and exercise capacity. Tomatidine has also been shown to significantly inhibit cholesterol ester accumulation induced by acetylated LDL in human monocyte-derived macrophages in a dose-dependent manner. Tomatidine also inhibits cholesterol ester formation in Chinese hamster ovary cells overexpressing acyl-CoA:cholesterol acyl-transferase (ACAT)-1 or ACAT-2, suggesting that tomatidine suppresses both ACAT-1 and ACAT-2 activities. The oral administration of tomatidine to apoE-deficient mice significantly reduces levels of serum cholesterol, LDL-cholesterol, and the size of atherosclerotic lesions.
Chemical Properties
Crystals. Decomposes at 275–280C.
Uses
Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling[1]. Tomatidine activates autophagy either in mammal cells or C elegans[2].
Definition
ChEBI: A 3beta-hydroxy steroid resulting from the substitution of the 3beta-hydrogen of tomatidane by a hydroxy group.
IC 50
p65; JNK
Purification Methods
Tomatidine forms plates from EtOAc. It is also purified by dissolving 80mg in *C6H6 and applying to an Al2O3 column (3.0g) and eluting with *C6H6, evaporating and recrystallising the residue three times from EtOAc. The hydrochloride has m 265-270o from EtOH and [] D 25 -5o (MeOH). [IR: Uhle J Am Chem Soc 83 1460 1961, Kessar et al. Tetrahedron 27 2869 1971, Schreiber & Adams Experientia 17 13 1961, Beilstein 27 III/IV 1950.]
References
[1] Chiu FL, et al. Tomatidine inhibits iNOS and COX-2 through suppression of NF-kappaB and JNK pathways in LPS-stimulated mouse macrophages. FEBS Lett. 2008 Jul 9;582(16):2407-12. DOI:10.1016/j.febslet.2008.05.049
[2] Anil Ahsan, et al. Tomatidine Protects Against Ischemic Neuronal Injury by Improving Lysosomal Function. Eur J Pharmacol. 2020 Jun 21;173280. DOI:10.1016/j.ejphar.2020.173280
TOMATIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21599 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 | jancyzheng@gcgreenpure.com | China | 954 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29833 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3751 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 1169 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
Related articles
- Tomatidine – a natural small molecule from tomato plants
- Tomatidine is the aglycone derivative of tomatine. Tomatidine belongs to the chemical family known as Spirosolanes and Derivat....
- Dec 24，2019
View Lastest Price from TOMATIDINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-01-20 | Tomatidine
77-59-8
|
US $58.00-42.00 / mg | 99.98% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Tomatidine
77-59-8
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2021-07-02 | tomatidine
77-59-8
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Tomatidine
77-59-8
- US $58.00-42.00 / mg
- 99.98%
- TargetMol Chemicals Inc.
-
- Tomatidine
77-59-8
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- tomatidine
77-59-8
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
