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H-CYS-4-ABZ-MET-OH

H-CYS-4-ABZ-MET-OH structure

CAS No.: 156707-43-6

Chemical Name:: H-CYS-4-ABZ-MET-OH

Synonyms: FTI II;FTASE INHIBITOR II;H-CYS-4-ABZ-MET-OH;FTase Inhibitor II（TFA salt）;CYSTEINE-(4-AMINOBENOZYL)METHIONINE;N-[4-[[(2R)-2-Amino-3-mercapto-1-oxopropyl]amino]benzoyl]-L-methionine;L-Methionine,N-[4-[[(2R)-2-aMino-3-Mercapto-1-oxopropyl]aMino]benzoyl]-;(2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropanoyl]amino]benzoyl]amino]-4-methylsulfanylbutanoic acid

CBNumber:: CB3777453

Molecular Formula:: C15H21N3O4S2

Molecular Weight:: 371.47

MDL Number:: MFCD00798742

MOL File:: 156707-43-6.mol

Last updated:2023-05-18 11:31:06

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H-CYS-4-ABZ-MET-OH Properties

Boiling point	700.6±60.0 °C(Predicted)
Density	1.363±0.06 g/cm3(Predicted)
storage temp.	-15°C
solubility	≤25mg/ml in
pka	3.46±0.10(Predicted)
form	crystalline solid

H-CYS-4-ABZ-MET-OH price More Price(12)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	16607	FTase Inhibitor II ≥80%	156707-43-6	1mg	$49	2024-03-01	Buy
Cayman Chemical	16607	FTase Inhibitor II ≥80%	156707-43-6	5mg	$168	2024-03-01	Buy
TRC	F810350	FTaseInhibitorII	156707-43-6	1mg	$45	2021-12-16	Buy
ApexBio Technology	C3203	FTaseInhibitorII	156707-43-6	5mg	$189	2021-12-16	Buy
Biosynth Carbosynth	FC109033	H-Cys-4-Abz-Met-OH	156707-43-6	10mg	$273	2021-12-16	Buy

Product number	Packaging	Price	Buy
16607	1mg	$49	Buy
16607	5mg	$168	Buy
F810350	1mg	$45	Buy
C3203	5mg	$189	Buy
FC109033	10mg	$273	Buy

H-CYS-4-ABZ-MET-OH Chemical Properties,Uses,Production

Uses

FTase Inhibitor II acts as a cell permeable analog of farnesyl pyrophosphate (FPP) that potently inhibits FTase. Possible cancer therapeutic agent

Biological Activity

ftase inhibitor ii is a potent farnesyl transferase inhibitor.protein prenylation is reported as a key mechanism by which functional association of proteins to membranes is mediated. ras proteins that are regulators of cell proliferation and differentiation are among the proteins undergoing farnesylation.

in vitro

previous study found that cells were treated with ftase inhibitor ii and two ggtase inhibitors (ggti-286 and ggti-2147) and the results showed that there was no change in cell growth in the presence of these inhibitors, even when 100 μm of the drugs were added to the culture. in addition, when cells were treated with a combination of ggti-2147 and ftase inhibitor ii, ranging from 0.1 nm to 100 μm, cell growth was not affected. additionally, in the presence of both 50 μm ftase inhibitor ii and 50 μm ggti-2147, the ftase and ggtase i enzyme activities were abolished [1].

References

[1] v. manne, c. s. ricca, j. g. brown, et al. ras farnesylation as a target for novel antitumor agents: potent and selective farnesyl diphosphate analog inhibitors of farnesyltransferase. drug development research 34, 121-137 (1995).

H-CYS-4-ABZ-MET-OH Preparation Products And Raw materials

Raw materials

Preparation Products

H-CYS-4-ABZ-MET-OH Suppliers

Global( 60)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Chengdu Youngshe Chemical Co., Ltd.	+8618108235634	Cecilia@youngshechem.com	China	2345	58
Nanjing TGpeptide	+86-13347807150 +86-13347807150	support@tgpeptide.com	China	3279	58
Zhejiang Hangyu API Co., Ltd	+8617531972939	anna@api-made.com	China	2944	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696;	info@hanhongsci.com	China	42982	64
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15421	60
BOC Sciences	16314854226	info@bocsci.com	United States	9926	65
Nanjing Leon Biological Technology Co., Ltd.	17705183659	sales@njleonbiotech.com	China	5504	55

Supplier	Advantage
Chengdu Youngshe Chemical Co., Ltd.	58
Nanjing TGpeptide	58
Zhejiang Hangyu API Co., Ltd	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
GL Biochem (Shanghai) Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky (shanghai) International Co.,Ltd	60
BOC Sciences	65
Nanjing Leon Biological Technology Co., Ltd.	55

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glutathione monoisopropyl ester H-TYR-TIC-PHE-PHE-OH N-BENZOYL-DL-METHIONINE BZ-MET-OH H-CYS-4-ABZ-MET-OH

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H-CYS-4-ABZ-MET-OH FTASE INHIBITOR II CYSTEINE-(4-AMINOBENOZYL)METHIONINE L-Methionine,N-[4-[[(2R)-2-aMino-3-Mercapto-1-oxopropyl]aMino]benzoyl]- (2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropanoyl]amino]benzoyl]amino]-4-methylsulfanylbutanoic acid FTI II N-[4-[[(2R)-2-Amino-3-mercapto-1-oxopropyl]amino]benzoyl]-L-methionine FTase Inhibitor II（TFA salt） 156707-43-6