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Chemical Name:
GAMMAP;ba35846;Ba 35846;γ-Picoline;picoline-4;p-Picoline;4-PICOLINE;g-picoline;sigma-Picoline;GAMMA-PICOLINE
Molecular Formula:
Formula Weight:
MOL File:

4-Methylpyridine Properties

Melting point:
2.4 °C(lit.)
Boiling point:
145 °C(lit.)
0.957 g/mL at 25 °C(lit.)
vapor density 
3.2 (vs air)
vapor pressure 
4 mm Hg ( 20 °C)
refractive index 
n20/D 1.504(lit.)
Flash point:
134 °F
storage temp. 
Flammables area
alcohol: soluble(lit.)
6.02(at 20℃)
Clear light yellow
explosive limit
Water Solubility 
Air Sensitive & Hygroscopic
CAS DataBase Reference
108-89-4(CAS DataBase Reference)
NIST Chemistry Reference
Pyridine, 4-methyl-(108-89-4)
EPA Substance Registry System
Pyridine, 4-methyl-(108-89-4)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T
Risk Statements  10-20/22-24-36/37/38
Safety Statements  26-36-45
RIDADR  UN 1992 3/PG 3
WGK Germany  1
RTECS  UT5425000
Autoignition Temperature 1000 °F
HazardClass  3
PackingGroup  III
HS Code  29333955
Hazardous Substances Data 108-89-4(Hazardous Substances Data)
Toxicity LD50 orally in rats: 1.29 g/kg (Smyth)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H226 Flammable liquid and vapour Flammable liquids Category 3 Warning
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H311 Toxic in contact with skin Acute toxicity,dermal Category 3 Danger P280, P302+P352, P312, P322, P361,P363, P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

4-Methylpyridine price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 131490 4-Methylpyridine 98% 108-89-4 25ml $26.8 2018-11-13 Buy
Sigma-Aldrich 239615 4-Methylpyridine 99% 108-89-4 50ml $33.6 2018-11-13 Buy
TCI Chemical P0417 4-Methylpyridine >98.0%(GC)(T) 108-89-4 25mL $14 2018-11-22 Buy
TCI Chemical P0417 4-Methylpyridine >98.0%(GC)(T) 108-89-4 500mL $32 2018-11-22 Buy
Alfa Aesar A15595 4-Picoline, 98% 108-89-4 100ml $18.2 2018-11-13 Buy

4-Methylpyridine Chemical Properties,Uses,Production

Chemical Properties

Clear light yellow liquid

Chemical Properties

Picolines are colorless liquids. Strong, unpleasant, pyridine-like odor.“Picoline” is often used as mixed isomers.


ChEBI: A methylpyridine in which the methyl substituent is at position 4.


manufacture of isonicotinic acid and derivatives. In waterproofing agents for fabrics. As solvent for resins.

General Description

Colorless moderately volatile liquid.

Air & Water Reactions

Highly flammable.

Reactivity Profile

4-Methylpyridine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

ACUTE/CHRONIC HAZARDS: Moderate fire risk.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Safety Profile

Poison by ingestion and intraperitoneal routes. Moderately toxic by sktn contact. Mildly toxic by inhalation. A severe skin and eye irritant. Flammable liquid when exposed to heat, flames, oxidizers. To fight fire, use alcohol foam. When heated to decomposition it emits toxic fumes of NOx.

Potential Exposure

(o-isomer); Suspected reprotoxic hazard, Primary irritant (w/o allergic reaction), (m-isomer): Possible risk of forming tumors, Primary irritant (w/o allergic reaction). Picolines are used as intermediates in pharmaceutical manufacture, pesticide manufacture; and in the manufacture of dyes and rubber chemicals. It is also used as a solvent.

First aid

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Speed in removing material from skin is of extreme importance. Shampoo hair promptly if contaminated. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.


UN2313 Picolines, Hazard Class: 3; Labels: 3-Flammable liquid.

Purification Methods

It can be purified as for 2-methylpyridine. Biddescombe and Handley's method (above) for 3-methylpyridine is also applicable. Lidstone [J Chem Soc 242 1940] purified it via the oxalate (m 137-138o) by heating 100mL of 4-methylpyridine to 80o and adding slowly110g of anhydrous oxalic acid, followed by 150mL of boiling EtOH. After cooling and filtering, the precipitate is washed with a little EtOH, then recrystallised from EtOH, dissolved in the minimum quantity of water and distilled with excess 50% KOH. The distillate is dried with solid KOH and again distilled. Hydrocarbons can be removed from 4-methylpyridine by converting the latter to its hydrochloride, crystallising from EtOH/diethyl ether, regenerating the free base by adding alkali and distilling. As a final purification step, 4-methylpyridine can be fractionally crystallised by partial freezing to effect a separation from 3-methylpyridine. Contamination with 2,6-lutidine is detected by its strong absorption at 270nm. The hydrochloride has m 161o, and the picrate has m 167o(from Me2CO, EtOH or H2O). [Beilstein 20 III/IV 2732, 20/5 V 543.]


Vapors may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Attacks copper and its alloys.

4-Methylpyridine Preparation Products And Raw materials

Raw materials

Preparation Products

4-Methylpyridine Suppliers

Global( 220)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22058 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20795 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32764 55
career henan chemical co
+86-371-86658258 CHINA 20001 58
Mei Lan Industrial (Shanghai) Co., Ltd. 021-61500788
021-58957967 China 2725 55
Wuhan EnTai Technology Development Co,.Ltd 86-27-82330560
86-27-82330547 China 353 69
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933; China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) China 40399 62
Alfa Aesar 400-610-6006; 021-67582000
021-67582001/03/05 China 30308 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
021-67121385 China 24654 81

View Lastest Price from 4-Methylpyridine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-09 4-Methylpyridine
US $2.00 / KG 1KG 99% Customise career henan chemical co

4-Methylpyridine Spectrum

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