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L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE

CAS No.
67953-08-6
Chemical Name:
L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE
Synonyms
H-GLU(PNA)-OH HCL;GPNA (hydrochloride);gamma-L-Glutamyl-4-nitroanilideHCl;7-bromo-6-oxocholestan-3-yl acetate;gamma-L-Glutamyl-p-nitroanilide HCl;L-GAMMA-GLUTAMYL-P-NITROANILIDE HYDROCHLORIDE;L-GAMMA-GLUTAMYL 4-NITROANILIDE HYDROCHLORIDE;GAMMA-L-GLUTAMYL-P-NITROANILIDE HYDROCHLORIDE;n-(4-nitrophenyl)-l-glutaminmonohydrochloride;N-(4-nitrophenyl)-L-glutamine monohydrochloride
CBNumber:
CB3779866
Molecular Formula:
C11H14ClN3O5
Molecular Weight:
303.7
MDL Number:
MFCD00039054
MOL File:
67953-08-6.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:13

L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE Properties

storage temp. 2-8°C
solubility Soluble in Water (up to 5 mg/ml).
form solid
color Off-white
Stability Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 1 month.
FDA UNII 7FHH4FVM3N
EPA Substance Registry System L-Glutamine, N-(4-nitrophenyl)-, monohydrochloride (67953-08-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Safety Statements  22-24/25
WGK Germany  3

L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich G6133 L-Glutamic acid γ-(p-nitroanilide) hydrochloride γ-glutamyl transpeptidase substrate 67953-08-6 1g $171 2024-03-01 Buy
Sigma-Aldrich G6133 L-Glutamic acid γ-(p-nitroanilide) hydrochloride γ-glutamyl transpeptidase substrate 67953-08-6 5g $232.8 2024-03-01 Buy
Sigma-Aldrich G6133 L-Glutamic acid γ-(p-nitroanilide) hydrochloride γ-glutamyl transpeptidase substrate 67953-08-6 25g $2030 2024-03-01 Buy
TRC G597108 L-Glutamic acid γ-(p-nitroanilide) hydrochloride 67953-08-6 100mg $70 2021-12-16 Buy
Chem-Impex 00412 L-Glutamicacidγ-(p-nitroanilide)hydrochloride,99%(HPLC) 99%(HPLC) 67953-08-6 1G $89.6 2021-12-16 Buy
Product number Packaging Price Buy
G6133 1g $171 Buy
G6133 5g $232.8 Buy
G6133 25g $2030 Buy
G597108 100mg $70 Buy
00412 1G $89.6 Buy

L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE Chemical Properties,Uses,Production

Description

L-γ-Glutamyl-p-nitroanilide (67953-08-6; GPNA) is a substrate for γ-glutamyl transpeptidase. GPNA is used for the determination of γ-glutamyl transpeptidase hydrolytic activity via spectrophotometric monitoring of p-nitroaniline released by the action of the enzyme on GPNA.1 GPNA has also been shown to be an inhibitor of glutamine uptake – solute-linked carrier family A1 member 5 (SLC1A5).2?Cellular uptake of L-glutamine (regulated by SLC1A5) is a rate-limiting step that activates mTOR and is, thus, an interesting cancer chemotherapy target.3

Uses

L-Glutamic acid gamma-(p-nitroanilide) is used in methods of treating cancers having a deregulated NRF2/KEAP1 pathway.

References

1) Meister?et al. (1981),?γ-Glutamyl transpeptidase; Methods Enzymol.,?77?237 2) Esslinger?et al. (2005),?N-gamma-aryl glutamine analogues as probes of the ASCT2 neutral amino acid transporter binding site; Bioorg. Med. Chem.,?13?1111 3) Nicklin?et al. (2012),?Bidirectional Transport of Amino Acid Regulates mTOR and Autophagy; Cell,?136?521

L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE Suppliers

Global( 64)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co
+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
GL Biochem(Binhai) Ltd.
+86-021-61263370 +8615301650015 wuqiuyan@glschina.com China 2975 58
BOC Sciences
+16314854226 inquiry@bocsci.com United States 19743 58
Nextpeptide Inc
+86-0571-81612335 +8613336028439 sales@nextpeptide.com China 19915 58
Nantong HI-FUTURE Biology Co., Ltd.
+undefined18051384581 sales@chemhifuture.com China 3136 58
LEAPCHEM CO., LTD.
+86-852-30606658 market18@leapchem.com China 43348 58
China Kouting Group Limited +86 (21) 5811-6473 5811-6475 sales@koutingchina.com China 496 60
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969 isunpharm@qq.com China 4428 55
Credit Asia Chemical Co., Ltd. +86 (21) 61124340 China 9767 58

View Lastest Price from L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE pictures 2020-01-13 L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE
67953-08-6
US $1.00 / g 1g 99.0% 100 kg Career Henan Chemical Co
H-GLU(PNA)-OH HCL L-GAMMA-GLUTAMYL 4-NITROANILIDE HYDROCHLORIDE L-GAMMA-GLUTAMYL-P-NITROANILIDE HYDROCHLORIDE L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE GAMMA-L-GLUTAMYL-P-NITROANILIDE HYDROCHLORIDE l-glutamic acid γ-(p-nitroanilide) hydrochloride L-Glutamic acid g-(p-nitroanilide) hydrochloride L-y-GLUTAMYL-p-NITROANILIDE HYDROCHLORIDE extrapure (4-amino-1-carboxy-4-keto-butyl)-(4-nitrophenyl)ammonium chloride (5-amino-1-hydroxy-1,5-dioxopentan-2-yl)-(4-nitrophenyl)azanium chloride L-glutamic acid gamma-(P-nitroanilide)*hydrochlor N-(4-nitrophenyl)-L-glutamine monohydrochloride L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE)*H YDROCHLORID gamma-L-Glutamyl-4-nitroanilideHCl n-(4-nitrophenyl)-l-glutaminmonohydrochloride (5-azanyl-1-hydroxy-1,5-dioxo-pentan-2-yl)-(4-nitrophenyl)azanium chloride (3-carbaMoyl-1-carboxy-propyl)-(4-nitrophenyl)azaniuM chloride GPNA (hydrochloride) (S)-2-Amino-5-((4-nitrophenyl)amino)-5-oxopentanoic acid hydrochloride 7-bromo-6-oxocholestan-3-yl acetate gamma-L-Glutamyl-p-nitroanilide HCl L-r-Glutamyl-p-Nitroanilide Hydrochloride extrapure, 99% Inhibitor,GGT,SNAT,GPNA,glutamine,lung,inhibit,ASCT2,Gln,Apoptosis,GPNA hydrochloride,γ-glutamyltransferase,LAT,A549,transporter 67953-08-6 C11H13N3O5HCl Chromogenic Activity