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(+)-EPIBATIDINE DIHYDROCHLORIDE

CAS No.
148152-66-3
Chemical Name:
(+)-EPIBATIDINE DIHYDROCHLORIDE
Synonyms
CMI 545;(±)Epibatidine,(±) Epibatidine;(+/-)-EPIBATIDINE HYDROCHLORIDE;(+)-EPIBATIDINE DIHYDROCHLORIDE;2-(6-CHLORO-PYRIDIN-3-YL)-7-AZA-BICYCLO[2.2.1]HEPTANE DIHYDROCHLORIDE;7-Azabicyclo[2.2.1]heptane, 2-(6-chloro-3-pyridinyl)-, (1R,2R,4S)-rel-;(+/-)-EXO-2-(6-CHLORO-3-PYRIDINYL)-7-AZABICYCLO[2.2.1]HEPTANE HYDROCHLORIDE;7-AZABICYCLO[2.2.1]HEPTANE, 2-(6-CHLORO-3-PYRIDINYL)-, DIHYDROCHLORIDE, EXO-;EXO[+/-]-2-[6-CHLORO-3-PYRIDINYL]-7-AZABICYCLO[2.2.1]HEPTANE DIHYDROCHLORIDE;EXO-(+)-1R,2R,4S-2-(6-CHLORO-3-PYRIDINYL)-7-AZABICYCLO[2.2.1]HEPTANE DIHYDROCHLORIDE
CBNumber:
CB3795844
Molecular Formula:
C11H13ClN2
Molecular Weight:
208.69
MDL Number:
MFCD00923801
MOL File:
148152-66-3.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59

(+)-EPIBATIDINE DIHYDROCHLORIDE Properties

Boiling point 336.7±32.0 °C(Predicted)
Density 1.223±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility insoluble in H2O; <24.55mg/ml in ethanol
pka 10.07±0.40(Predicted)
form solid
color Off White
Water Solubility Soluble to 5 mM in water and to 100 mM in ethanol

(+)-EPIBATIDINE DIHYDROCHLORIDE price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC E582200 (±)-Epibatidine 148152-66-3 2.5mg $195 2021-12-16 Buy
TRC E582200 (±)-Epibatidine 148152-66-3 5mg $430 2021-12-16 Buy
TRC E582200 (±)-Epibatidine 148152-66-3 25mg $1540 2021-12-16 Buy
ApexBio Technology B6406 (±)-Epibatidine 148152-66-3 10mg $448 2021-12-16 Buy
Product number Packaging Price Buy
E582200 2.5mg $195 Buy
E582200 5mg $430 Buy
E582200 25mg $1540 Buy
B6406 10mg $448 Buy

(+)-EPIBATIDINE DIHYDROCHLORIDE Chemical Properties,Uses,Production

Uses

(-)-Epibatidine has binding affinities for α4β2 and α3β4 nicotinic receptors.

Definition

ChEBI: 3-(6-chloro-3-pyridinyl)-7-azabicyclo[2.2.1]heptane is an alkaloid.

Biological Activity

(+)-aj 76 hydrochloride is an antagonist of dopamine autoreceptor with pki values of 6.95, 6.67, 6.37, 6.21 and 6.07 for hd3, hd4, hd2s, hd2l and rd2 receptors, respectively.dopamine receptor is a g protein-coupled receptor and mainly exists in the vertebrate central nervous system (cns). dopamine receptor is a receptor for dopamine and plays a critical role in memory, learning, pleasure, cognition, motivation and fine motor control.(+)-aj 76 hydrochloride is a dopamine receptor antagonist. in rats, aj76 stimulated locomotor activity and increased the levels of 3,4-dihydroxyphenylacetic acid (dopac) and hva in brain, which were dopamine metabolites [1]. in rats injected with cocaine, (+)-a j76 increased the locomotor stimulation during the first 30 min. however, (+)-aj76 inhibited the later more intense locomotor stimulation and cocaine-induced stereotypies [2]. in vivo, (+)-aj76 induced dopamine release mainly through interaction with dopamine receptors in the terminal regions of the a9 and a10 dopaminergic fibers. however, (+)-aj76 increased the level of dopac via the somatodendritic autoreceptors [3].

storage

Desiccate at +4°C

References

[1]. kullingsjö h, carlsson a, svensson k. effects of repeated administration of the preferential dopamine autoreceptor antagonist, (+)-aj76, on locomotor activity and brain da metabolism in the rat. eur j pharmacol, 1991, 205(3): 241-246.
[2]. piercey mf, lum jt, hoffmann we, et al. antagonism of cocaine's pharmacological effects by the stimulant dopaminergic antagonists, (+)-aj76 and (+)-uh232. brain res, 1992; 588(2): 217-222.
[3]. waters n, hansson l, löfberg l, et al. intracerebral infusion of (+)-aj76 and (+)-uh232: effects on dopamine release and metabolism in vivo. eur j pharmacol, 1994, 251(2-3): 181-190.

(+)-EPIBATIDINE DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

(+)-EPIBATIDINE DIHYDROCHLORIDE Suppliers

Global( 15)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8449 60
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9730 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44941 58
cjbscvictory 13348960310 13348960310 3003867561@qq.com China 9945 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24131 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 3913 58
ApexBio Technology -- sales@apexbt.com United States 6254 58
(+)-EPIBATIDINE DIHYDROCHLORIDE (+/-)-EPIBATIDINE HYDROCHLORIDE EXO-(+)-1R,2R,4S-2-(6-CHLORO-3-PYRIDINYL)-7-AZABICYCLO[2.2.1]HEPTANE DIHYDROCHLORIDE EXO[+/-]-2-[6-CHLORO-3-PYRIDINYL]-7-AZABICYCLO[2.2.1]HEPTANE DIHYDROCHLORIDE (+/-)-EXO-2-(6-CHLORO-3-PYRIDINYL)-7-AZABICYCLO[2.2.1]HEPTANE HYDROCHLORIDE 2-(6-CHLORO-PYRIDIN-3-YL)-7-AZA-BICYCLO[2.2.1]HEPTANE DIHYDROCHLORIDE 7-AZABICYCLO[2.2.1]HEPTANE, 2-(6-CHLORO-3-PYRIDINYL)-, DIHYDROCHLORIDE, EXO- CMI 545 7-Azabicyclo[2.2.1]heptane, 2-(6-chloro-3-pyridinyl)-, (1R,2R,4S)-rel- (±)Epibatidine,(±) Epibatidine 148152-66-3