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ALK5 inhibitor II

CAS No.
446859-33-2
Chemical Name:
ALK5 inhibitor II
Synonyms
RepSox;E-616452;CS-204;E616452;SJN 2511;E 616452;RepSox, >=98%;RepSox(E-616452;ALK5 INHIBITOR I;RepSox (SJN 2511)
CBNumber:
CB3806232
Molecular Formula:
C17H13N5
Molecular Weight:
287.32
MDL Number:
MFCD09037561
MOL File:
Mol file
MSDS File:
SDS
Last updated:2023-09-04 16:42:00

ALK5 inhibitor II Properties

Melting point 195 °C
Boiling point 501.9±50.0 °C(Predicted)
Density 1.296±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: >20mg/mL
form Yellow solid
pka 10.05±0.50(Predicted)
color Pale yellow
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey LBPKYPYHDKKRFS-UHFFFAOYSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P280-P305+P351+P338
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811
WGK Germany  3
NFPA 704
0
2 0

ALK5 inhibitor II price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich R0158 RepSox ≥98% (HPLC) 446859-33-2 5mg $134 2024-03-01 Buy
Sigma-Aldrich R0158 RepSox ≥98% (HPLC) 446859-33-2 25mg $565 2024-03-01 Buy
Sigma-Aldrich 5.08158 InSolution TGF-β RI Kinase Inhibitor II, RepSox - CAS 446859-33-2 - Calbiochem 446859-33-2 5mg $126 2024-03-01 Buy
TCI Chemical R0224 RepSox 446859-33-2 5MG $68 2024-03-01 Buy
TCI Chemical R0224 RepSox 446859-33-2 25MG $211 2024-03-01 Buy
Product number Packaging Price Buy
R0158 5mg $134 Buy
R0158 25mg $565 Buy
5.08158 5mg $126 Buy
R0224 5MG $68 Buy
R0224 25MG $211 Buy

ALK5 inhibitor II Chemical Properties,Uses,Production

Description

RepSox (446859-33-2) is a potent (IC50?ALK5 auto-P= 4 nM; IC50?TGF-β cellular assay = 23 nM) inhibitor of the TGF-β type I receptor (ALK5).1?RepSox can replace Sox2 in reprogramming adult cells into pluripotent stem cells via induction of Nanog transcription.2?It was able to convert astrocytes into neuronal cells as part of a small molecule cocktail (along with valproic acid and CHIR99021).3,4

Uses

Alk 5 Inhibitor II is a selective ATP competitive inhibitor of transforming growth factor-β (TGFβ). A potential drug for the treatment of fibrosis and cancer.

Uses

RepSox has been used as an inhibitor of autophosphorylation of the transforming growth factor β type I receptor kinase (ALK5). It has also been used as a basal media component for culturing human Pluripotent stem cells.

Definition

ChEBI: 1,5-naphthyridine, 2-[3-(6-methyl-2-pyridinyl)-1h-pyrazol-4-yl]- is a pyrazolopyridine.

Biochem/physiol Actions

RepSox Inhibits TGF-beta receptor signaling. Retroviral transduction of Sox2, Oct4, and Klf4 genes results in direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs).

storage

+4°C

References

1) Gellibert?et al. (2004),?Identification of 1,5-Naphthyridine Derivatives as a Novel Series of Potent and Selective TGF-β Type I Receptor Inhibitors; J. Med. Chem.?47?4494 2) Ichida?et al.?(2009),?A Small-molecule Inhibitor of TGF-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog; Cell Stem Cell?5?491 3) Cheng?et al.?(2015),?Direct Conversion of astrocytes into neuronal cells by a drug cocktail;?Cell Res.?25?1269 4) Cheng?et al.?(2014),?Generation of neural progenitor cells by chemical cocktails and hypoxia; Cell Res.?24?665

ALK5 inhibitor II Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 180)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9359 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29919 58
Biochempartner
0086-13720134139 candy@biochempartner.com CHINA 967 58
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22968 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Alchem Pharmtech,Inc.
8485655694 sales@alchempharmtech.com United States 63711 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47464 58

View Lastest Price from ALK5 inhibitor II manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-(3-(6-METHYLPYRIDIN-2-YL)-1H-PYRAZOL-4-YL)-1,5-NAPHTHYRIDINE pictures 2019-07-06 2-(3-(6-METHYLPYRIDIN-2-YL)-1H-PYRAZOL-4-YL)-1,5-NAPHTHYRIDINE
446859-33-2
US $1.00 / KG 1KG 98% 1kg,5kg,100kg Career Henan Chemical Co

ALK5 inhibitor II Spectrum

ALK5 INHIBITOR I 2-(3-(6-METHYLPYRIDIN-2-YL)-1H-PYRAZOL-4-YL)-1,5-NAPHTHYRIDINE 2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine SJN 2511 2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine E 616452 E616452 1,5-Naphthyridine, 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]- RepSox 2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine RepSox, >=98% RepSox(E-616452 TGF-BETA RI KINASE INHIBITOR II TRANSFORMING GROWTH FACTOR-BETA TYPE I RECEPTOR KINASE INHIBITOR I RepSox(ALK5 Inhibitor II) TGF-β RI Kinase Inhibitor II RepSox (SJN 2511) ALK5 Inhibitor II E-616452;SJN 2511;ALK5 INHIBITOR II;TGF-&BETA RI KINASE INHIBITOR II TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem InSolution TGF-β RI Kinase Inhibitor II, RepSox - CAS 446859-33-2 - Calbiochem E-616452; SJN 2511; E616452; SJN2511; E 616452; SJN-2511 CS-204 E-616452 RepSox 2-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine 446859-33-2 Selective inhibitor of the TGF-β type I receptor ALK5. Smad TGF-beta Inhibitors