Zotatifin
- CAS No.
- 2098191-53-6
- Chemical Name:
- Zotatifin
- Synonyms
- Zotatifin;Zotatifin (Synonyms: eFT226);4-[(2S,3R,4S,5S,6R)-4-[(dimethylamino)methyl]-2,3-dihydroxy-10,12-dimethoxy-5-phenyl-7-oxa-11-azatricyclo[6.4.0.02,6]dodeca-1(12),8,10-trien-6-yl]benzonitrile;Benzonitrile, 4-[(5aR,6S,7S,8R,8aS)-7-[(dimethylamino)methyl]-6,7,8,8a-tetrahydro-8,8a-dihydroxy-1,3-dimethoxy-6-phenyl-5aH-cyclopenta[4,5]furo[3,2-c]pyridin-5a-yl]-
- CBNumber:
- CB38067114
- Molecular Formula:
- C28H29N3O5
- Molecular Weight:
- 487.55
- MDL Number:
- MFCD32874093
- MOL File:
- 2098191-53-6.mol
| Boiling point | 622.4±55.0 °C(Predicted) |
|---|---|
| Density | 1.36±0.1 g/cm3(Predicted) |
| pka | 10.10±0.70(Predicted) |
| form | Solid |
| color | White to off-white |
| InChIKey | QYCXWOACFWMQFO-WZWZCULESA-N |
| SMILES | C(#N)C1=CC=C([C@]23[C@H](C4=CC=CC=C4)[C@@H](CN(C)C)[C@@H](O)[C@@]2(O)C2=C(O3)C=C(OC)N=C2OC)C=C1 |
| FDA UNII | 2EWN8Z05CN |
| NCI Drug Dictionary | zotatifin |
Zotatifin price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0043584 | Zotatifin 99.58% | 2098191-53-6 | 1mg | $1350 | 2021-12-16 | Buy |
| ChemScene | CS-0043584 | Zotatifin 99.58% | 2098191-53-6 | 2mg | $2500 | 2021-12-16 | Buy |
| ChemScene | CS-0043584 | Zotatifin 99.58% | 2098191-53-6 | 5mg | $3800 | 2021-12-16 | Buy |
Zotatifin Chemical Properties,Uses,Production
Uses
Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC50=2 nM) and interferes with the assembly of the eIF4F initiation complex[1]. Zotatifin shows robust antiviral effects, it effectively reduces viral infectivity by inhibiting SARS-CoV-2 NP protein biogenesis (IC90=37 nM)[2]. Zotatifin induces cell apoptosis[1].
in vivo
Zotatifin (intravenous injection; 1 mg/kg; 14-22 days) decreases tumor volume, inhibits the TMD8 xenograft-bearing, HBL1 xenograft-bearing, Pfeiffer xenograft-bearing, SU-DHL-6 xenograft-bearing, SU-DHL-10 xenograft-bearing and Ramos-bearing animals’tumor growth as percentage of 97%, 87%, 70%, 83%, 37% and 75%, respectively[1].Zotatifin (intravenous injection; 0.001 mg/kg-1 mg/kg; 15 days) inhibits the growth of B-cell lymphoma xenografts and is well-tolerated against B-cell lymphoma xenograft models in vivo[1].
| Animal Model: | B-cell lymphoma xenograft model[1] |
| Dosage: | 0.001 mg/kg; 0.1 mg/kg; 1 mg/kg |
| Administration: | Intravenous injection; 15 days |
| Result: | Showed efficacy in B-cell lymphoma xenograft models. |
IC 50
eIF4
References
[1] Peggy A. Thompson, et al. Preclinical Evaluation of eFT226, a Novel, Potent and Selective eIF4A Inhibitor with Anti-tumor Activity in B-cell Malignancies.
[2] Gordon DE, et al. A?SARS-CoV-2?protein?interaction?map?reveals?targets?for?drug?repurposing.Nature.?2020 Apr 30. DOI:10.1038/s41586-020-2286-9
Zotatifin Preparation Products And Raw materials
Raw materials
Preparation Products
Zotatifin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32342 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38730 | 58 | |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Chengdu PEIP Pharmaceutical Technology Co., LTD. | 028-61715638 18011352545 | 1242335275@qq.com | China | 398 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3478 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 7991 | 62 |
| Shanghai SuperLan Chemcial Technique Centre | 021-2022843681 15618226720 | lucy@atkchemical.com | China | 10017 | 58 |
