METHYL 6-BROMOQUINOLINE-2-CARBOXYLATE
- CAS No.
- 623583-88-0
- Chemical Name:
- METHYL 6-BROMOQUINOLINE-2-CARBOXYLATE
- Synonyms
- methyl 2-bromoquinoline-6-carboxylate;METHYL 6-BROMOQUINOLINE-2-CARBOXYLATE;6-Bromo-quinoline-2-carboxylic acid methyl ester;2-Quinolinecarboxylic acid, 6-bromo-, methyl ester
- CBNumber:
- CB3814044
- Molecular Formula:
- C11H8BrNO2
- Molecular Weight:
- 266.09
- MDL Number:
- MFCD08436465
- MOL File:
- 623583-88-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
METHYL 6-BROMOQUINOLINE-2-CARBOXYLATE price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | HCH0356046 | METHYL-6-BROMOQUINOLINE-2-CARBOXYLATE 95.00% | 623583-88-0 | 5MG | $505.92 | 2021-12-16 | Buy |
| AK Scientific | 4318AJ | Methyl6-bromoquinoline-2-carboxylate | 623583-88-0 | 5g | $2397 | 2021-12-16 | Buy |
| Chemenu | CM123373 | methyl6-bromoquinoline-2-carboxylate 97% | 623583-88-0 | 1g | $306 | 2021-12-16 | Buy |
| Crysdot | CD11087141 | Methyl6-bromoquinoline-2-carboxylate 97% | 623583-88-0 | 1g | $324 | 2021-12-16 | Buy |
| Chemenu | CM123373 | methyl6-bromoquinoline-2-carboxylate 97% | 623583-88-0 | 5g | $916 | 2021-12-16 | Buy |
METHYL 6-BROMOQUINOLINE-2-CARBOXYLATE Chemical Properties,Uses,Production
Synthesis
67-56-1
65148-10-9
623583-88-0
1c) Synthesis of methyl 6-bromo-2-quinolinecarboxylate A mixture of 6-bromo-2-quinolinecarboxylic acid (331 g, multiple batches, 1.31 mol) and methanesulfonic acid (22 mL, 33 g, 0.34 mol) in methanol (2 L) was refluxed for 6 hours. Upon completion of the reaction, the reaction mixture was neutralized with an aqueous solution of sodium bicarbonate (29 g, 0.34 mol) (350 mL). The resulting suspension was slowly cooled to 20 °C and stirred continuously overnight. The solid product was collected by filtration and the filter cake was washed with water (1 L). The solid product was dried in a vacuum oven at 50 °C for 3 days to give methyl 6-bromo-2-quinolinecarboxylate (294 g, 85% yield). 1H NMR (400 MHz, DMSO-d6) δ 8.52 (d, J = 9 Hz, 1H), 8.40 (d, J = 2 Hz, 1H), 8.14 (d, J = 9 Hz, 1H), 8.08 (d, J = 9 Hz, 1H), 7.97 (m, 1H), 3.93 (s, 3H). ES-LCMS m/z 267 (M + H)+.
References
[1] Patent: US2008/96921, 2008, A1. Location in patent: Page/Page column 32
[2] Tetrahedron, 2014, vol. 70, # 42, p. 7686 - 7690
[3] Patent: WO2011/127643, 2011, A1. Location in patent: Page/Page column 38
METHYL 6-BROMOQUINOLINE-2-CARBOXYLATE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29731 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 | sales@cdforestchem.com | China | 2000 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66028182 18626450290 | yftan@aikonchem.com | China | 16679 | 50 |
| ShangHai Wisacheam Pharmaceutical Co., Ltd. | 13817485796 | tim@wisacheampharm.com | China | 3586 | 58 |
| JW & Y Pharmlab Co., Ltd. | 021-64340559 13651849907; | xinyu_shi@jwypharmlab.com.cn | China | 12035 | 58 |
| Shanghai RenYue Chemical Technology Co., Ltd. | 021-62219190; 18321139117 | 316441092@qq.com | China | 2581 | 55 |
| Shanghai Huaxing Biological Technology Co., Ltd. | 18621295758; 18621295758 | 1449085402@qq.com | China | 1820 | 55 |
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