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Dexmedetomidine hydrochloride

Dexmedetomidine hydrochloride
Dexmedetomidine hydrochloride structure
CAS No.
145108-58-3
Chemical Name:
Dexmedetomidine hydrochloride
Synonyms
CS-1397;Precedex;DEMEDETOMIDINE HCL;DEXMEDETOMIDINE HCL;Dexmedetomidine hydr;Dexmedetomidine(Pilot);Dexmedetomidine HCl 99%;DeMedetoMidine hydrochloride;Omega cinnamate methyl ester;DEXMEDETOMIDINE HYDROCHLORIDE
CBNumber:
CB3838381
Molecular Formula:
C13H17ClN2
Formula Weight:
236.74
MOL File:
145108-58-3.mol

Dexmedetomidine hydrochloride Properties

Melting point:
156.5-157.5°
alpha 
+52.4° (c = 1 in water)
Density 
1.17 g/cm3
storage temp. 
2-8°C
solubility 
H2O: soluble20mg/mL, clear
form 
powder
color 
white to beige
optical activity
[α]/D +48 to +58°, c = 1 in H2O
Merck 
14,2946
InChIKey
VPNGEIHDPSLNMU-MERQFXBCSA-N
CAS DataBase Reference
145108-58-3(CAS DataBase Reference)
FDA UNII
1018WH7F9I
NCI Drug Dictionary
dexmedetomidine hydrochloride
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P301+P312+P330-P305+P351+P338-P261
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26-36/37/39
WGK Germany  3
RTECS  NI5156750
HS Code  2933290000

Dexmedetomidine hydrochloride price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0956 Dexmedetomidine hydrochloride ≥98% (HPLC) 145108-58-3 10mg $96.5 2021-03-22 Buy
Sigma-Aldrich PHR2701 Dexmedetomidine Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material 145108-58-3 500MG $199 2021-03-22 Buy
Sigma-Aldrich 1179333 Dexmedetomidine hydrochloride United States Pharmacopeia (USP) Reference Standard 145108-58-3 200mg $366 2020-08-18 Buy
TCI Chemical D5062 Dexmedetomidine Hydrochloride >98.0%(HPLC)(T) 145108-58-3 20mg $57 2021-03-22 Buy
TCI Chemical D5062 Dexmedetomidine Hydrochloride >98.0%(HPLC)(T) 145108-58-3 100mg $218 2021-03-22 Buy

Dexmedetomidine hydrochloride Chemical Properties,Uses,Production

Description

Dexmedetomidine was launched in the US as an i.v. infusion for sedation of initially intubated and mechanically ventilated patients during treatment in an intensive care unit, This imidazole derivative is the (S)-enantiomer of medetomidine that can be obtained via fractional crystallization of the tartrate salt of the racemic mixture. Dexmedetomidine is a full agonist of α2 adrenoceptors with 1300-fold selectivity versus α1 compared to the less selective partial α2 agonist clonidine, a veterinary hypnotic. Dexmedetomidine is unique compared with currently available sedatives in that it provides sedation, analgesia and anxiolysis with the ability of patients to be easily awakened. Besides, it causes minimal respiratory depression unlike other available drugs such as benzodiazepines or opioids. Pharmacological studies in transgenic mice showed that the sedative, anesthetic and analgesic effects of dexmedetomidine are specifically due to the stimulation of the a2A subtype receptor. Like other α2 adrenoceptor agonists, dexmedetomidine can provoke hypotension and bradycardia probably because of its non-selective action on peripheral a2B subtype receptors in vascular smooth muscle. Dexmedetomidine is extensively metabolized into methyl and glucuronide conjugates which are mainly eliminated by renal excretion. It was found to be a CYP2D6 inhibitor but less potent than the clinically relevant standard quinidine.

Originator

Orion (Finland)

Uses

highly selective, potent α2-adrenoceptor agonist, analgesic, anxiolytic, bradycardic, hypotensive, sedative, hypothermic

brand name

Precedex

Biological Activity

Active isomer of Medetomide (4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazolehydrochloride ), a potent, highly selective α 2 -adrenoceptor agonist (K i values are 1.08 and 1750 nM for α 2 - and α 1 -adrenoceptors respectively). Displays greater selectivity over α 1 -adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Active in vivo ; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.

Dexmedetomidine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Dexmedetomidine hydrochloride Suppliers

Global( 318)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hebei Zhanyao Biotechnology Co. Ltd
15369953316 15369953316
admin@zhanyaobio.com CHINA 1953 58
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
+86 (576) 8169-6105 sales@frappschem.com China 886 50
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20918 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8909 55
Guangzhou PI PI Biotech Inc
+8618371201331
020-81716319 sales@pipitech.com;87478684@qq.com China 3245 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3013 60
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26751 60

View Lastest Price from Dexmedetomidine hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-26 dexmedetomidine HCL
145108-58-3
US $1.00 / g 10g 99% 10kg Jinan Ande Pharmaceutical Co.,Ltd.
2021-11-25 Dexmedetomidine hydrochloride
145108-58-3
US $30.00 / ASSAYS 1ASSAYS 99% 100ton Shanghai Yunao International Trade Co., Ltd
2021-11-02 Dexmedetomidine hydrochloride
145108-58-3
US $79.00 / g 1g 99 10kg Baoji Guokang Healthchem co.,ltd

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