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Chloroacetone

CAS No.
78-95-5
Chemical Name:
Chloroacetone
Synonyms
1-CHLOROPROPAN-2-ONE;Cholroacetone;MONOCHLOROACETONE;Chloropropanone;1-Chloropropanone;Chloroacetone (stabilized with MgO);Tonite;A-Stoff;CH3COCH2Cl;oroacetone
CBNumber:
CB3854389
Molecular Formula:
C3H5ClO
Molecular Weight:
92.52
MDL Number:
MFCD00000936
MOL File:
78-95-5.mol
Last updated:2023-11-28 16:31:43

Chloroacetone Properties

Melting point -44.5 °C
Boiling point 120 °C (lit.)
Density 1.162 g/mL at 25 °C (lit.)
vapor pressure 42 hPa (20 °C)
refractive index n20/D 1.432(lit.)
Flash point 82 °F
storage temp. 2-8°C
solubility Chloroform, Methanol (Slightly)
form Liquid
Specific Gravity 1.162
color Clear yellow to yellow-brown
PH 4.3 (124g/l, H2O, 20°C)
explosive limit 3.4%(V)
Water Solubility 124 g/L (20 ºC)
Sensitive Lachrymatory
Merck 14,2114
BRN 605369
Dielectric constant 29.8(20℃)
Stability Stable. Incompatible with strong oxidizing agents, strong bases. May discolour on exposure to light. STENCH.
LogP 2.7 at 20℃
CAS DataBase Reference 78-95-5(CAS DataBase Reference)
FDA UNII 60ZTR74268
NIST Chemistry Reference 2-Propanone, 1-chloro-(78-95-5)
EPA Substance Registry System Chloroacetone (78-95-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS06,GHS09
Signal word  Danger
Hazard statements  H226-H301-H310+H330-H315-H319-H335-H410
Precautionary statements  P210-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  T+,N,T,F,Xi
Risk Statements  10-24/25-26-36/37/38-50/53
Safety Statements  16-23-36/37/39-45-60-61-38-28A-26
RIDADR  UN 1695 6.1/PG 1
WGK Germany  3
RTECS  UC0700000
8-19
Autoignition Temperature 610 °C
Hazard Note  Irritant/Flammable/Toxic/Lachrymatory
TSCA  Yes
HazardClass  6.1
PackingGroup  I
HS Code  29147000
Toxicity LD50 (14 day) in mice, rats (mg/kg): 127, 100 orally; LC50 (1 hr) in rats (ppm): 262 by inhalation (Sargent)

Chloroacetone price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 167479 Chloroacetone 95% 78-95-5 5G $22.4 2024-03-01 Buy
Sigma-Aldrich 167479 Chloroacetone 95% 78-95-5 100g $40.6 2024-03-01 Buy
Sigma-Aldrich 167479 Chloroacetone 95% 78-95-5 500g $78 2024-03-01 Buy
Sigma-Aldrich 10905 Chloroacetone produced by Wacker Chemie AG, Burghausen, Germany, ≥96.0% (GC) 78-95-5 1KG $176.8 2024-03-01 Buy
Sigma-Aldrich 10905 Chloroacetone produced by Wacker Chemie AG, Burghausen, Germany, ≥96.0% (GC) 78-95-5 220KG $5610 2024-03-01 Buy
Product number Packaging Price Buy
167479 5G $22.4 Buy
167479 100g $40.6 Buy
167479 500g $78 Buy
10905 1KG $176.8 Buy
10905 220KG $5610 Buy

Chloroacetone Chemical Properties,Uses,Production

Chemical Properties

colourless to dark yellow liquid

Uses

Manufacture of couplers for color photography; intermediate in manufacture of perfumes, antioxidants, drugs, plant growth regulators, defoliants, and herbicides

Uses

Couplers for color photography, enzyme inactivator, insecticides, perfumes, intermediate, organic synthesis, tear gas, polymerization of vinyl monomers.

Uses

Chloroacetone was used in the synthesis of double-chain nonionic surfactants with an acid decomposition function via acid-catalyzed condensation with fatty alcohols (octyl, decyl and dodecyl). It was also used in the synthesis of meso-tetramethyl tetrakis-(4-phenoxy acetone)calix[4]pyrrole. It can also be used to make dye couplers for color photography and used in the Feist-Benary synthesis of furans.

Definition

A lachrymator.

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 5274, 1955 DOI: 10.1021/ja01625a016
Synthesis, p. 188, 1987 DOI: 10.1055/s-1987-27886

General Description

A yellow-colored liquid with an irritating pungent odor. Light sensitive, but stabilized with the addition of small amounts of water and/or calcium carbonate. Slightly soluble in water and denser than water. Vapors much heavier than air. Irritates skin and eyes. Very toxic by ingestion or inhalation. Used to make other chemicals. A lachrymator.

Air & Water Reactions

Highly flammable. Water soluble.

Reactivity Profile

CHLOROACETONE turns dark and resinifies on prolonged exposure to light [Merck]. This occurred in a bottle during storage for two years on a shelf in diffused light. A few days after the bottle was moved, Chloroacetone exploded [Ind. Eng. News 9: 184(1931)]. Is stabilized by addition of 0.1% water or 0.1% CaCO3.

Hazard

Strong irritant to tissue, eyes, and mucous membranes; toxic by ingestion and skin contact. Upper respiratory tract irritant.

Health Hazard

TOXIC; may be fatal if inhaled, ingested or absorbed through skin. Inhalation or contact with some of these materials will irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion and poison hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Flammability and Explosibility

Flammable

Safety Profile

Poison by inhalation, ingestion, and skin contact. Mutation data reported. A lachrymator poison gas. See also CHLORINATED HYDROCARBONS, ALIPHATIC; ACETONE. Flammable when exposed to heat or flame, or oxidizers. Old material can explode. When heated to decomposition it emits highly toxic fumes.

Purification Methods

Dissolve it in water and shake it repeatedly with small amounts of diethyl ether which extracts, preferentially, 1,1-dichloroacetone present as an impurity. The chloroacetone is then extracted from the aqueous phase using a large amount of diethyl ether, and distilled at slightly reduced pressure. It is dried with CaCl2 and stored at Dry-ice temperature. Alternatively, it was stood over CaSO4, distilled and stored over CaSO4. It is steam volatile. The 2,4-dinitrophenylhydrazone forms yellow needles from EtOH with m 120o or 124o. [Beilstein 1 IV 3215.] LACHRYMATOR with toxic vapour.

CHLOROACETONE (STABILISED) FOR SYNTHESIS Chloroacetone produced by Wacker Chemie AG, Burghausen, Germany, >=96.0% (GC) Chloroacetone, 95%, stabilized 1-chloro-2-ketopropane[qr] 1-chloro-2-oxopropane 1-chloro-2-oxopropane[qr] 1-chloro-2-propanon 1-Chloroacetone 1-chloroacetone[qr] 2-Propanone,1-chloro- 2-propanone,1-chloro-[qr] 3-Chloro-2-propanone Acetonyl Chloride 1-Chloro-2-propanone 1-CHLORO-2-PROPANONE AKOS BBS-00004082 CHLOROACETONE (controlled chemical) MONOCHLOROPROPANONE Chloraceton CHLOROACETONE , STABILIZED WITH 0.1% EPOXIDIZED SOYBEAN OIL Chloroacetonetech CHLOROACETONE, 90+% 1-Chloropropan-2-one, Chloro-2-propanone Chloroacetone,96%,stabilized Chloroacetone, Stab. With 0.1% Epoxidized Soybean Oil 1-Chloroacetone 95% 1-chloro-2-ketopropane Acetone, chloro- acetone,chloro-[qr] acetonylchloride[qr] alpha-Chloroacetone alpha-chloroacetone[qr] A-Stoff CH3COCH2Cl Chloracetone chloracetone(french)[qr] chloro-1propanone-2 chloro-2-propanone[qr] chloro-aceton chloroacetone,stabilized chloroacetone[qr] Chloromethyl methyl ketone chloromethylmethylketone chloromethylmethylketone[qr] chloropropanone[qr] Monochloracetone monochloracetone[qr] monochloroacetone[qr] Tonite ACETONYL CHLORIDE CHLOROACETONE CHLORO-2-PROPANONE CHLOROACETONE, WACKER QUALITY CHLOROACETONE, STAB. Chloroacetone,95%,stab.with0.1%epoxidizedsoybeanoil CHLOROACETONE (STABILISED) oroacetone JACS-78-95-5 Chloroacetone 95% stabilized with 0.5% CaCO3