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paraflutizide

paraflutizide
paraflutizide structure
CAS No.
1580-83-2
Chemical Name:
paraflutizide
Synonyms
LD-3612;paraflutizide;6-Chloro-3-(p-fluorobenzyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide;6-chloro-3-(4-fluorobenzyl)-1,1-diketo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide;6-chloro-3-[(4-fluorophenyl)methyl]-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide;2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-[(4-fluorophenyl)methyl]-3,4-dihydro-, 1,1-dioxide
CBNumber:
CB3875049
Molecular Formula:
C14H13ClFN3O4S2
Formula Weight:
405.85
MOL File:
1580-83-2.mol

paraflutizide Properties

Melting point:
238-240°
Boiling point:
636.2±65.0 °C(Predicted)
Density 
1.571±0.06 g/cm3(Predicted)
pka
8.66±0.40(Predicted)
FDA UNII
53A5V9FGN9
SAFETY
  • Risk and Safety Statements
Toxicity LD50 oral in mouse: > 10gm/kg

paraflutizide Chemical Properties,Uses,Production

Originator

Paraflutizide, Shanghai Lansheng

Manufacturing Process

A mixture of 5.0 g (0.0357 g/mol) of ρ-fluorophenylethyl alcohol, 2.0 g (0.007 g/mol) of 5-chloro-2,4-disulphamylaniline, 2.0 g (0.0068 g/mol) of potassium bichromate and 15 ml of concentrated hydrochloric acid (0.176 g/mol) and 25 ml of water is heated under reflux for 1 h. The mixture is allowed to cool, and 15 ml of ether are added to separate the excess of ρ-fluorophenylethyl alcohol. The aqueous layer is decanted and frozen for 2 h and the precipitate is separated, washed with water and dried in vacuum over phosphoric anhydride. There are collected 1.35 g (yield 47.5%) of the 1,1-dioxide of 3-ρfluorophenyl-methyl-7-sulphamyl-6-chloro-3,4-dihydrobenzo-1,2,4-thiadiazine, which when recrystallised from 30 ml of 50% alcohol on "Norit" active carbon takes the form of a white crystalline substance, melting point is 239°C.

Therapeutic Function

Diuretic

paraflutizide Preparation Products And Raw materials

Raw materials

Preparation Products


paraflutizide Suppliers

Global( 4)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Waterstone Technology, LLC --
-- sales@waterstonetech.com United States 6805 30
Lanospharma Laboratories Co.,Ltd --
-- sales@lanospharma.com China 6351 56
Shanghai New Union Textra Import & Export Co., Ltd --
-- zhou@pharmchemical.com China 2761 60
CHEMICAL LAND21 --
-- sales21@chemicalland21.com South Korea 6338 74

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