Guanfacine
- CAS No.
- 29110-47-2
- Chemical Name:
- Guanfacine
- Synonyms
- C07037;SPD503;SPD 503;SPD-503;Guanfacine;Guanfacine USP/EP/BP;Guanfacine free base;Guanfacine Solution, 100ppm;[(2,6-Dichlorophenyl)acetyl]guanidine;2-(2,6-Dichlorophenylacetyl)guanidine
- CBNumber:
- CB3875216
- Molecular Formula:
- C9H9Cl2N3O
- Molecular Weight:
- 246.09
- MDL Number:
- MFCD00865944
- MOL File:
- 29110-47-2.mol
| Melting point | 227-230?C |
|---|---|
| Density | 1.50±0.1 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | Soluble in DMSO |
| form | Powder |
| pka | 11.92±0.46(Predicted) |
| BCS Class | 1 |
| EWG's Food Scores | 1 |
| FDA UNII | 30OMY4G3MK |
| ATC code | C02AC02 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 |
Guanfacine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | G816000 | Guanfacine | 29110-47-2 | 10mg | $145 | 2021-12-16 | Buy |
| Usbiological | 012992 | Guanfacine | 29110-47-2 | 1mg | $566 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0026077 | GUANFACINE 95.00% | 29110-47-2 | 10MG | $187.95 | 2021-12-16 | Buy |
| ApexBio Technology | B3394 | Guanfacine | 29110-47-2 | 50mg | $252 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611661 | Guanfacine | 29110-47-2 | 250mg | $606.9 | 2021-12-16 | Buy |
Guanfacine Chemical Properties,Uses,Production
Chemical Properties
White Solid
Originator
Estulic,Sandoz,Switz.,1980
Uses
Centrally acting α-adrenoceptor agonist. Antihypertensive.
Uses
Guanfacine centrally acting α-adrenoceptor agonist. Guanfacine is an antihypertensive.
Definition
ChEBI: Guanfacine is a member of acetamides.
Manufacturing Process
2,6-Dichlorophenyl-acetyl-guanidine: A solution of 3.245 g (0.055 mol) of
guanidine in isopropanol is added to a solution of 11.7 g (0.05 mol) of 2,6-
dichlorophenyl-acetic acid ethyl ester (BP 142°C to 143°C/12 mm of Hg) in
20cc of isopropanol. The reaction mixture is allowed to stand overnight and is
subsequently concentrated by evaporation. After recrystallizing the residue
from methanol/ether 2,6-dichlorophenyl-acetyl-guanidine is obtained in the
form of white grains having a MP of 225°C to 227°C.
2,6-Dichlorophenyl-acetyl-guanidine hydrochloride: A solution of 5.6 g (0.025
mol) of 2,-dichlorophenylacetic acid chloride (BP 137°C to 138°C/12 mm of
Hg) in 10 cc of toluene is added dropwise to a mixture of 4.5 g (0.076 mol) of
guanidine and 60 cc of toluene. The reaction mixture is allowed to stand at
room temperature for 20 minutes, is then heated on a steam bath for 2 hours
and is subsequently cooled. The resulting precipitate is filtered off and washed
twice with 25 cc amounts of water in order to separate the guanidine
hydrochloride. The residue (2,6-dichlorophenyl-acetyl-guanidine) is washed
with chloroform for further purification and is then dissolved in 50 cc of
isopropanol. The pH-value of the solution is adjusted to 6 with ethanolic
hydrochloric acid and the solution is cooled. The resulting white needles are
again washed with chloroform. The resulting 2.6-dichlorophenyl-acetylguanidine hydrochloride has a MP of 213°C to 216°C.
brand name
Tenex (Dr. Reddy’s).
Therapeutic Function
Antihypertensive
General Description
Guanfacine is more selective for 2-receptors than isclonidine. Their mechanism of action is the same as that ofclonidine. Differences between clonidine and its twoanalogs are seen in their elimination half-life values and intheir metabolism and urinary excretion patterns. The eliminationhalf-life of clonidine ranges from 20 to 25 hours,whereas that for guanfacine is about 17 hours. Guanabenzhas the shortest DOA of these three agents, with a half-lifeof about 6 hours. Clonidine and guanfacine are excretedunchanged in the urine to the extent of 60% and 50%,respectively. Very little of guanabenz is excreted unchangedin the urine.
Synthesis
Guanfacin, N-amidino-2-(2,6-dichlorophenyl)acetamide (22.3.2), is also synthesized in a very easy synthesis of reacting the acid chloride or ester of 2,6- dichlorophenylacetic acid with guanidine.
Guanfacine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9553 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29474 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12382 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Wuhan Han Sheng New Material Technology Co.，Ltd | +8617798174412 | admin01@hsnm.com.cn | China | 2118 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
View Lastest Price from Guanfacine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-11 | Guanfacine USP/EP/BP
29110-47-2
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2020-05-10 | Guanfacine
29110-47-2
|
US $0.00-0.00 / Kg | 1KG | 99.0% | 500 MT | Shaanxi Dideu Medichem Co. Ltd |
-
- Guanfacine USP/EP/BP
29110-47-2
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Guanfacine
29110-47-2
- US $0.00-0.00 / Kg
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd