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oxprenolol

CAS No.
6452-71-7
Chemical Name:
oxprenolol
Synonyms
Coretal;Tevacor;Oxenalol;Aids001596;Aids-001596;dl-Oxprenolol;Oxprenolol-d7;oxprenolol USP/EP/BP;Coretal (hydrochloride);6452-73-9 (Hydrochloride)
CBNumber:
CB3875564
Molecular Formula:
C15H23NO3
Molecular Weight:
265.35
MDL Number:
MFCD00243001
MOL File:
6452-71-7.mol
Last updated:2023-05-15 10:43:41

oxprenolol Properties

Melting point 78-80°
Boiling point 408.57°C (rough estimate)
Density 1.0479 (rough estimate)
refractive index 1.5000 (estimate)
solubility Dichloromethane (Slightly), Methanol (Slightly)
form Solid
pka 13.89±0.20(Predicted)
color White to Off-White
Stability Stable under recommended storage conditions., Stable Under Recommended Storage C
FDA UNII 519MXN9YZR

SAFETY

Risk and Safety Statements

oxprenolol price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation RDL0007030 OXPRENOLOL-D7 95.00% 6452-71-7 5MG $505.25 2021-12-16 Buy
Product number Packaging Price Buy
RDL0007030 5MG $505.25 Buy

oxprenolol Chemical Properties,Uses,Production

Description

Oxprenolol induced contact dermatitis in a worker at a pharmaceutical plant, in the division for drug synthesis. Epichlorhydrin was also used for the production of both propranolol and oxprenolol.

Originator

Trasicor,Ciba Geigy ,Italy,1970

Uses

Oxprenolol is a free base of Oxprenolol Hydrochloride(O870500) which is a β-Adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic.

Uses

Vasodilator(coronary).

Definition

ChEBI: 1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol is an aromatic ether.

Manufacturing Process

75 grams of pyrocatechol monoallyl ether, 75 grams of epichlorohydrin, 75 grams of potassium carbonate and 400 ml of acetone are stirred and heated at the boil for 12 hours. The potassium carbonate is then filtered off. The solvent is distilled off in a water-jet vacuum. The residual oil is dissolved in ether and agitated with 2 N sodium hydroxide solution. The ether is separated, dried and distilled off. The residue is distilled in a water-jet vacuum. 3-(ortho-allyloxy-phenoxy)-1,2-epoxypropane passes over at 145° to 157°C under 11 mm Hg pressure. A solution of 15 grams of 3-(ortho-allyloxyphenoxy)-1,2-epoxypropane and 15 grams of isopropylamine in 20 ml of ethanol is refluxed for 4 hours. The excess amine and the alcohol are then distilled off under vacuum, to leave 1-isopropylamino-2-hydroxy-3-(orthoallyloxy-phenoxy)-propane which melts at 75° to 80°C after recrystallization from hexane.

brand name

Trasicor (Novartis).

Therapeutic Function

Antiarrhythmic

Contact allergens

The beta-blocker oxprenolol induced contact dermatitis in a worker at a pharmaceutical plant, in a division for drug synthesis. Epichlorhydrin was also used for the production of drugs propranolol and oxprenolol.

oxprenolol Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 17)Suppliers
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Hubei Jusheng Technology Co.,Ltd.
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TOSUN PHARM 13326451905 2881290884@qq.com China 7386 58
1-(2-allyloxyphenoxy)-3-isopropylaminopropan-2-ol 2-Propanol, 1-(1-methylethyl)amino-3-2-(2-propenyloxy)phenoxy- 1-(Isopropylamino)-2-hydroxy-3-[o-(allyloxy)phenoxy]propane 1-[o-(Allyloxy)phenoxy]-3-(isopropylamino)-2-propanol 2-Propanol, 1-[(1-methylethyl)amino]-3-[2-(2-propenyloxy)phenoxy]- (9CI) 2-Propanol, 1-[o-(allyloxy)phenoxy]-3-(isopropylamino)- (7CI, 8CI) Coretal dl-Oxprenolol 1-(2-Allyloxyphenoxy)-3-(isopropylamino)-2-propanol 1-(Isopropylamino)-3-[2-(2-propenyloxy)phenoxy]-2-propanol 1-[2-(Allyloxy)phenoxy]-3-(isopropylamino)-2-propanol 6452-73-9 (Hydrochloride) Aids001596 Aids-001596 Coretal (hydrochloride) Oxprenolol-d7 1-(2-allyloxyphenoxy)-2-hydroxy-3-isopropylaminopropane 2-Propanol, 1-[(1-methylethyl)amino]-3-[2-(2-propen-1-yloxy)phenoxy]- oxprenolol USP/EP/BP Tevacor Oxenalol 6452-71-7