metiazinic acid
- CAS No.
- 13993-65-2
- Chemical Name:
- metiazinic acid
- Synonyms
- Metian;Soripal;RP 16091;Ambrunate;Novartril;Soridermal;Metiazinic;metiazinic acid;(10-METHYL2-PHENOTHIAZINYL)ACETICACID;10H-Phenothiazine-2-acetic acid, 10-methyl-
- CBNumber:
- CB3889277
- Molecular Formula:
- C15H13NO2S
- Molecular Weight:
- 271.33
- MDL Number:
- MFCD00866023
- MOL File:
- 13993-65-2.mol
Melting point | 146℃ |
---|---|
Boiling point | 482.6±44.0 °C(Predicted) |
Density | 1.2237 (rough estimate) |
refractive index | 1.7500 (estimate) |
pka | 4.12±0.10(Predicted) |
Water Solubility | 31mg/L(30 ºC) |
FDA UNII | 12I0HHE2ZY |
metiazinic acid Chemical Properties,Uses,Production
Originator
Soripan,Specia,France,1970
Definition
ChEBI: Phenothiazine substituted at nitrogen by a methyl group and at C-2 by a carboxymethyl group.
Manufacturing Process
10-Methyl-3-acetylphenthiazine is prepared in accordance with G. Cauquil and A. Casadevall, Bull. Soc.Chim., p 768 (1955). (10-Methyl-3-phenthiazinyl)acetic acid (MP 146°C; 21.4 g) is prepared by Willgerodt's reaction (action of sulfur and morpholine, followed by hydrolysis) employing 10-methyl-3-acetylphenthiazine as starting material.
Therapeutic Function
Antiinflammatory
Trade name
Roimal (Kantoishi, Japan), Soripal (Torii, Japan).
Synthesis
Metiazinic acid is prepared via
the Willgerodt reaction (sulfur and morpholine)
from 2-acetyl-10-methylphenothiazine.
Dosage
Metiazinic acid has been beneficial to arthritis patients when given at a daily dose of 0.75 – 1.5 g/d.
metiazinic acid Preparation Products And Raw materials
metiazinic acid Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
Supplier | Advantage |
---|---|
TargetMol Chemicals Inc. | 58 |
TargetMol Chemicals Inc. | 58 |