metiazinic acid

CAS No.
13993-65-2
Chemical Name:
metiazinic acid
Synonyms
Metian;Soripal;RP 16091;Ambrunate;Novartril;Soridermal;Metiazinic;metiazinic acid;(10-METHYL2-PHENOTHIAZINYL)ACETICACID;10H-Phenothiazine-2-acetic acid, 10-methyl-
CBNumber:
CB3889277
Molecular Formula:
C15H13NO2S
Molecular Weight:
271.33
MDL Number:
MFCD00866023
MOL File:
13993-65-2.mol
Last updated:2023-04-23 13:52:06

metiazinic acid Properties

Melting point 146℃
Boiling point 482.6±44.0 °C(Predicted)
Density 1.2237 (rough estimate)
refractive index 1.7500 (estimate)
pka 4.12±0.10(Predicted)
Water Solubility 31mg/L(30 ºC)
FDA UNII 12I0HHE2ZY

SAFETY

Risk and Safety Statements

Toxicity LD50 in mice, rats (mg/kg): 800, ~500 orally (Joulou)

metiazinic acid price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation API0003349 METIAZINIC ACID 95.00% 13993-65-2 5MG $499.29 2021-12-16 Buy
Product number Packaging Price Buy
API0003349 5MG $499.29 Buy

metiazinic acid Chemical Properties,Uses,Production

Originator

Soripan,Specia,France,1970

Definition

ChEBI: Phenothiazine substituted at nitrogen by a methyl group and at C-2 by a carboxymethyl group.

Manufacturing Process

10-Methyl-3-acetylphenthiazine is prepared in accordance with G. Cauquil and A. Casadevall, Bull. Soc.Chim., p 768 (1955). (10-Methyl-3-phenthiazinyl)acetic acid (MP 146°C; 21.4 g) is prepared by Willgerodt's reaction (action of sulfur and morpholine, followed by hydrolysis) employing 10-methyl-3-acetylphenthiazine as starting material.

Therapeutic Function

Antiinflammatory

Trade name

Roimal (Kantoishi, Japan), Soripal (Torii, Japan).

Synthesis

Metiazinic acid is prepared via the Willgerodt reaction (sulfur and morpholine) from 2-acetyl-10-methylphenothiazine.
Synthesis of metiazinic acid

Dosage

Metiazinic acid has been beneficial to arthritis patients when given at a daily dose of 0.75 – 1.5 g/d.

metiazinic acid Preparation Products And Raw materials

Raw materials

Preparation Products

metiazinic acid Suppliers

Global( 5)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24131 58
metiazinic acid Metiazinic (10-METHYL2-PHENOTHIAZINYL)ACETICACID Ambrunate Metian Novartril RP 16091 Soridermal Soripal (10-methyl-10H-phenothiazin-2-yl)acetic acid 10H-Phenothiazine-2-acetic acid, 10-methyl- 13993-65-2