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Paxlovid

CAS No.
2628280-40-8
Chemical Name:
Paxlovid
Synonyms
nirmatrelvir;3-Azabicyclo[3.1.0]hexane-2-carboxamide,N- [(1S)-1-cyano-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]- 3-[(2S)-3,3-dimethyl-1-oxo-2-[(2,2,2- trifluoroacetyl)amino]butyl]-6,6-dimethyl-, (1R,2S,5S)-;(1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;Nirmatrelvir (PF-07321332);Paxlovid (PF-07321332);PF07321332(Paxlovid);3-Azabicyclo[3.1.0]hexane-2-carboxamide,N- [(1S)-1-cyano-2-[...;PF-07321332;NIRMALTAVIR;Niramatrelvir
CBNumber:
CB38941263
Molecular Formula:
C23H32F3N5O4
Molecular Weight:
499.53
MDL Number:
MFCD34473213
MOL File:
2628280-40-8.mol
Last updated:2024-03-27 14:23:05

Paxlovid Properties

Boiling point 742.4±60.0 °C(Predicted)
Density 1.267±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 140 mg/mL (280.26 mM; Need ultrasonic)
form A solid
pka 10.26±0.46(Predicted)
InChIKey LIENCHBZNNMNKG-OJFNHCPVSA-N
SMILES [C@@]12([H])[C@@]([H])(C1(C)C)CN(C(=O)[C@@H](NC(C(F)(F)F)=O)C(C)(C)C)[C@@H]2C(N[C@H](C#N)C[C@@H]1CCNC1=O)=O
FDA UNII 7R9A5P7H32

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
NFPA 704
0
2 0

Paxlovid price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML3313 PF-07321332 ≥95% (HPLC) 2628280-40-8 5MG $86.5 2024-03-01 Buy
Sigma-Aldrich SML3313 PF-07321332 ≥95% (HPLC) 2628280-40-8 25MG $280 2024-03-01 Buy
Product number Packaging Price Buy
SML3313 5MG $86.5 Buy
SML3313 25MG $280 Buy

Paxlovid Chemical Properties,Uses,Production

Synthesis

In a 2 L three-necked flask, add 36.4 g (0.1 mol) of solid material SM1, dissolve with 360ml butanone, then add 19.9 g Intermediate C (0.105 mol), 8.3g HOPO (0.075 mol) and stir for 10min, then add 38.7 g DIPEA (0.3 mol), stirred for 10min, then added 26.6 g EDCI (0.15 mol), reacted at 20-25°C for 16-18 h, the raw material point basically disappeared in TLC, and phosphoric acid aqueous solution (85%, 0.15 mol, 47.5 g was added to the reaction solution) ) and 360 ml of saturated sodium chloride solution, stirred for 30 min, left to stand for stratification, let go of the lower water layer, add 360 ml of sodium chloride solution and 360 ml of isopropyl acetate solution to the organic layer, extract and separate liquids, and concentrate the organic layer to obtain 45.6 g of crude product, the yield is 91.3%.
   In the there-necked flask of 2 L, add crude product (50 g, 0.1 mol), 500 ml isopropyl acetate, be heated to 65-70°C after solids are all dissolved, under this temperature condition, add the n-heptane of 750 ml , heat preservation and stirring 6-7 h, separate out a large amount of solid, be cooled to room temperature, filter, filter cake is washed with the organic solvent F of 300 ml (wherein, organic solvent F is that isopropyl acetate and n-heptane are mixed by volume ratio of 1:1 mixed solution), and dried to obtain 46.2 g of pure product with a yield of 92.3%.    Paxlovid

Description

PF-07321332 is an oral COVID-19 antiviral clinical candidate. By inhibiting the main protease, PF-07321332 prevents the virus from cleaving long protein chains into the parts it needs to reproduce itself.

Uses

PF-07321332 (nirmatrelvir) is an oral antiviral clinical lead. It is a covalent inhibitor of SARS-CoV-2 Mpro (main protease, 3CLpro) that binds to cysteine145 within the enzyme's catalytic domain. Mpro is essential for coronavirus replication. Inhibiting Mpro actvity blocks replication at an early stage in the virus' life cycle. Due to structural similarities between the Mpro's of other coronavirusus, PF-07321332 offers the potential of pan-coronavirus activity. In vitro it is suggested to inhibit replication of CoV-2 variants including delta and omicron.

Definition

ChEBI: Nirmatrelvir is an azabicyclohexane that is (1R,5S)-3-azabicyclo[3.1.0]hexane substituted by {(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl}aminoacyl, 3-methyl-N-(trifluoroacetyl)-L-valinamide, methyl and methyl groups at positions 2S, 3, 6 and 6, respectively. It is the first orally administered inhibitor of SARS-CoV-2 main protease developed by Pfizer and used in combination with ritonavir for the treatment of COVID-19. It has a role as an EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor and an anticoronaviral agent. It is a nitrile, a member of pyrrolidin-2-ones, a secondary carboxamide, a pyrrolidinecarboxamide, a tertiary carboxamide, an organofluorine compound and an azabicyclohexane.

Biological Activity

PF-07321332 is an orally bioavailable 3C-like protease (3CLPRO) inhibitor. This drug is being investigated for safety, tolerability, and pharmacokinetics before moving on to studies of efficacy in the treatment or prophylaxis of COVID-19. 3CLPRO is responsible for cleaving polyproteins 1a and 1ab of SARS-CoV-2.

Structure and conformation

PF-07321332 is structurally similar to ML1000. PF-07321332's chemical structure was formally disclosed in Owen et al's Science article in November 2021, and this confirmed the structure that was obtained from the ACS meeting.

Paxlovid Preparation Products And Raw materials

Raw materials

Preparation Products

Paxlovid Suppliers

Global( 263)Suppliers
Supplier Tel Email Country ProdList Advantage
weifang runzhong fine chemical co., ltd
536-7868377 +8618653686003 sq@runzhongchem.com China 187 58
Wuhan Biocar Pharmacy Co., Ltd.
+86-13669031409 +8613669031409 jason@biocar.cn China 742 58
Hangzhou Proserre Chemical Co.,Ltd.
+86-571-86088112 info@proserre.com China 1077 58
Jiangxi Huihe Chemical Co., Ltd.
+86-19189228086 +8618858568638 wuzhouding@huihecrop.com China 886 58
HangZhou RunYan Pharma Technology Co.,LTD.
+86-88660901 +86-18112526015 sales@runyanpharma.com China 326 58
shandong perfect biotechnology co.ltd
+86-53169958659; +8618596095638 sales@sdperfect.com China 294 58
Henan Tengmao Chemical Technology Co. LTD
+8615238638457 salesvip2@hntmhg.com China 415 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2504 58
Anhui Ruihan Technology Co., Ltd
+8617756083858 daisy@anhuiruihan.com China 994 58
Nantong Guangyuan Chemicl Co,Ltd
+undefined17712220823 admin@guyunchem.com China 616 58

Related articles

View Lastest Price from Paxlovid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Paxlovid pictures 2024-03-29 Paxlovid
2628280-40-8
US $3860.00-3850.00 / kg 1kg 99% 100Tons Hebei Dangtong Import and export Co LTD
PAXLOVID  pictures 2024-03-29 PAXLOVID
2628280-40-8
US $1.00 / g 1g 99+% 20t Jinan Jianfeng Chemical Co., Ltd
Nirmatrelvir pictures 2024-03-27 Nirmatrelvir
2628280-40-8
US $20.00 / kg 1kg 99 1000kg Shaanxi Franta Biotechnology Co., Ltd
  • Paxlovid pictures
  • Paxlovid
    2628280-40-8
  • US $3860.00-3850.00 / kg
  • 99%
  • Hebei Dangtong Import and export Co LTD
  • PAXLOVID  pictures
  • PAXLOVID
    2628280-40-8
  • US $1.00 / g
  • 99+%
  • Jinan Jianfeng Chemical Co., Ltd
  • Nirmatrelvir pictures
  • Nirmatrelvir
    2628280-40-8
  • US $20.00 / kg
  • 99
  • Shaanxi Franta Biotechnology Co., Ltd

2628280-40-8(Paxlovid)Related Search:

PF-07321332 PF-07321332-005 Nirmatrelvir-product under research Unii-7R9A5P7H32 3-Azabicyclo[3.1.0]hexane-2-carboxamide,N- [(1S)-1-cyano-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]- 3-[(2S)-3,3-dimethyl-1-oxo-2-[(2,2,2- trifluoroacetyl)amino]butyl]-6,6-dimethyl-, (1R,2S,5S)- PF07321332(Paxlovid) nirmatrelvir Nirmatrelvir (PF-07321332) (1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide 3-Azabicyclo[3.1.0]hexane-2-carboxamide,N- [(1S)-1-cyano-2-[... Paxlovid (PF-07321332) (1R,2S,5S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide Niramatrelvir 2H9]-Nirmatrelvir (1R,2S,5S)-N-[(S)-1-Cyano-2-[(S)-2-oxo-3-pyrrolidinyl]ethyl]-3-[(S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide (alphaR)-alpha-[ll2-(4-Nitrophenyl)ethyllamino] methyl]benzenemethanol hydrochloride PF07321332(nirmatrelvir) NIRMALTAVIR 2628280-40-8 1 API paxlovid 2628280-40-8