(±)-2-[4-[3-[[4-benzamido-5-(dipropylamino)glutaryl]oxy]propyl]-1-piperazinyl]ethyl 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate, compound with maleic acid (1:2)
- CAS No.
- 59209-40-4
- Chemical Name:
- (±)-2-[4-[3-[[4-benzamido-5-(dipropylamino)glutaryl]oxy]propyl]-1-piperazinyl]ethyl 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate, compound with maleic acid (1:2)
- Synonyms
- D01765;CR 604;Afloxan;Protaxon;Protacine;Miridacin;Miridacin (tn);Proglumetacin dimaleate;Proglumetacin maleate (jan);(±)-2-[4-[3-[[4-benzamido-5-(dipropylamino)glutaryl]oxy]propyl]-1-piperazinyl]ethyl 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate, compound with maleic acid (1:2)
- CBNumber:
- CB3899447
- Molecular Formula:
- C46H58ClN5O8.2C4H4O4
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
(±)-2-[4-[3-[[4-benzamido-5-(dipropylamino)glutaryl]oxy]propyl]-1-piperazinyl]ethyl 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate, compound with maleic acid (1:2) Properties
| Melting point | 146-148° |
|---|---|
| FDA UNII | F2PUN24B8C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS09,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H400 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501-P273-P391-P501 |
| Toxicity | LD50 in male mice, rats (mg/kg): 262, 450 orally (Rovati) |
(±)-2-[4-[3-[[4-benzamido-5-(dipropylamino)glutaryl]oxy]propyl]-1-piperazinyl]ethyl 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate, compound with maleic acid (1:2) price
(±)-2-[4-[3-[[4-benzamido-5-(dipropylamino)glutaryl]oxy]propyl]-1-piperazinyl]ethyl 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate, compound with maleic acid (1:2) Chemical Properties,Uses,Production
Definition
ChEBI: A maleate salt obtained by combining proglumetacin with two molar equivalents of maleic acid. Used to control pain and inflammation associated with musculoskeletal and joint disorders. Following oral adminitration, it is metabolied to indometacin and progl mide, a drug with antisecretory effects that helps prevent injury to the stomach lining.
General Description
Proglumetacin at a dose of 450 mg/d appears to be as effective as 150 mg/d of indomethacin in the treatment of a wide variety of rheumatic conditions, and is faster acting with significantly lower incidence and severity of adverse effects. It is metabolized to several derivatives, including indomethacin, in humans.
Trade name
Afloxan (Rotta Research, Italy), Protaxil (Rottapharm, Spain), Protaxon (Opfermann, Germany), Proxil (Rottapharm, Italy), Tolindol (La Meuse, Belgium).
Synthesis
alkylation of the anticholinergic agent proglumide with N-(3-chloropropyl)-N'-(2-hydroxyethyl)piperazine using
sodium methoxide in dimethyl sulfoxide gives N-[3-(N-benzoyl-N' ,N '-di-npropyl-dl-isoglutaminyl)oxypropyl]-N'-(2-
hydroxyethyl)piperazine, which is then condensed with indomethacin using dicyclohexylcarbodiimide. The resulting ester is treated
with maleic acid to give proglumetacin maleate.
(±)-2-[4-[3-[[4-benzamido-5-(dipropylamino)glutaryl]oxy]propyl]-1-piperazinyl]ethyl 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate, compound with maleic acid (1:2) Preparation Products And Raw materials
Raw materials
Preparation Products
(±)-2-[4-[3-[[4-benzamido-5-(dipropylamino)glutaryl]oxy]propyl]-1-piperazinyl]ethyl 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate, compound with maleic acid (1:2) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Yick-Vic Chemicals & Pharmaceuticals (HK) Ltd | -- | sales@yickvic.com | China | 6214 | 58 |
| Supplier | Advantage |
|---|---|
| Yick-Vic Chemicals & Pharmaceuticals (HK) Ltd | 58 |