4-hydroxybutanal
- CAS No.
- 25714-71-0
- Chemical Name:
- 4-hydroxybutanal
- Synonyms
- 4-Hydroxybutanal;4-Hydroxybutana;Einecs 247-205-3;Butanal, 4-hydroxy-;4-hydroxybutyraldehyde;gamma-Hydroxybutyraldehyde;4-hydroxybutanal Basic information;4-Hydroxybutanal and 2-Hydroxytetrahydrofuran;4-Hydroxybutanal and 2-Hydroxytetrahydrofuran (Equilibrium Mixture)
- CBNumber:
- CB3901650
- Molecular Formula:
- C4H8O2
- Molecular Weight:
- 88.11
- MDL Number:
- MOL File:
- 25714-71-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-Hydroxybutanal | B443928 | 100mg | $195 |
| Boiling point | 103.07°C (rough estimate) |
|---|---|
| Density | 1.0808 |
| refractive index | 1.4384 |
| storage temp. | Refrigerator |
| solubility | Chloroform (Sparingly), Ethyl Acetate (Slightly) |
| pka | 14.89±0.10(Predicted) |
| form | Oil |
| color | Colourless |
| Stability | Hygroscopic |
| FDA UNII | 8T59P1Q6NO |
| EPA Substance Registry System | Butanal, 4-hydroxy- (25714-71-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| TSCA | TSCA listed |
4-hydroxybutanal price More Price(1)
4-hydroxybutanal Chemical Properties,Uses,Production
Uses
4-Hydroxybutanal is used in preparation of deoxykeoses and acetonides. 4-Hydroxybutanal is also a metabolite of Tegafur , a prodrug used for various cancer chemotherapies.
Reactions
4-Hydroxybutanal forms a cyclic hemiacetal when the hydroxyl oxygen add to the aldehyde group. Methanol reacts with this cyclic hemiacetal to form 2-methoxytetrahydrofuran which is our desired product.2-Methoxytetrahydrofuran is a cyclic acetal. The hydroxyl oxygen of 4-Hydroxybutanal reacts with the aldehyde to form cyclic ether linkage.
Synthesis
The 4-hydroxybutanal which is produced as the high yield product of the invention hydroformylation process can be separated and recovered by conventional distillation procedures. It is highly preferred, however, to subject the hydroformylation product mixture to aqueous phase extraction. Surprisingly it was found that water is capable of extracting 4-hydroxybutanal from the product mixture substantially to the exclusion of the other product mixture components. In a commercial scale operation, an aqueous phase stream can be contacted countercurrently and continuously with reaction product effluent from the hydroformylation reaction zone. The resultant aqueous phase containing 4-hydroxybutanal is an excellent vehicle for subsequent processing procedures, such as hydrogenation of 4-hydroxybutanal with Raney nickel to produce valuable 1,4-butanediol.
literature source US04064145
References
[1] QINGYONG MENG Ming B H Chenggen Zhang. A theoretical model study on the cyclic reaction of 4-hydroxybutanal catalyzed by Brnsted acid[J]. Canadian Journal of Chemistry, 2009, 68 1: 1610-1619. DOI:10.1139/V09-126.
[2] LUDMILA LEITE. Transformation of 4-hydroxybutanal over porcelain[J]. Journal of Molecular Catalysis A: Chemical, 1999, 144 2: Pages 323-328. DOI:10.1016/S1381-1169(98)00382-3.
[3] https://patents.google.com/patent/CN114149312A/en
4-hydroxybutanal Preparation Products And Raw materials
4-hydroxybutanal Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21592 | 55 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15079 | 58 |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9333 | 58 |
| Xuzhou B&C Chemical Technology Co., Ltd | +86-400-0516-021 +86-15190678838 | wuh@bcpharma.com | China | 2732 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Compound Net Biotechnology Inc. | +8615303909093 | sales@compound-net.com | China | 2914 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53802 | 58 |
| Sinco Pharmachem (ShenZhen) R&D Co., Ltd. | +undefined18603013401 | jack.lin@sincopharmachem.com | China | 9996 | 58 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9416 | 55 |
View Lastest Price from 4-hydroxybutanal manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-11-25 | 4-hydroxybutanal Basic information
25714-71-0
|
US $1.00 / kg | 1kg | 98% | 1000kg | Henan Aochuang Chemical Co.,Ltd. |
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- 4-hydroxybutanal Basic information
25714-71-0
- US $1.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
